Stability, solubility and thermodynamic properties of dimorphs of furosemide-4,4′-bipyridine cocrystals in organic solvents

Furosemide Adducts with Hexamethylenetetramine, Amantadine, and Isoniazid: A Structural Case That Demonstrates the Effect of Carboxylic Acid Dimer and Sulfonic Acid Dimer on the Solubility

“…The strategy of pharmaceutical cocrystals has also been applied in the enhanced solubility of FS . FS contains extensive functional groups (−COOH, −SO 2 NH 2 , and NH−), which have a potential to form cocrystals with some certain coformers from the viewpoint of crystal engineering. , For example, Nangia et al reported a series of FS cocrystals by introducing the coformers with good solubility, such as caffeine, adenine, and cytosine, which led to the increased solubility (6–11 fold) compared with FS itself . The furosemide–gefitinib molecular salt hydrate showed better solubility (35–40 μg/mL) and dissolvation, which was related to the hydrogen-bonding interactions, crystal density, crystal packing, and crystal lattice .…”

Simulation of Co-Crystal Solubility in the Mono-Solvents at Different Temperatures

“…Apleblat equation collected from the literature. [9][10][11] Careful examination of the listed MPD values in Table 2 revealed that the proposed model provides reasonably accurate correlations for the solubility of the investigated co-crystals. The model fits all solubility data of a co-crystal in different mono-solvents at various temperatures whereas Apelblat, van't Hoff and λh models fit the solubility of a cocrystal in a given solvent at various temperatures.…”

“…By including these parameters in the van't Hoff equation, the entropic and enthalpic changes during dissolution of a drug in the various mono-solvents are correlated with the mono-solvents' parameters and provide the capability of extension of the applicability of the model to other mono-solvents. The most significant (p < 0.05) independent variables obtained from the regression of the solubility data of three investigated cocrystals (stable co-crystal in solution after equilibration) in the mono-solvents at various temperatures [9][10][11]…”