Stability Studies of a Mixture of Paracetamol and Ascorbic Acid, Prepared Extempore, at Elevated Temperature and Humidity Conditions

Golonka, Iwona; Kawacki, Andrzej; Musiał, Witold

doi:10.4314/tjpr.v14i8.1

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…This test is carried out to identify the physical stability of the compounded preparation and to establish a Beyond Use Date. Table 1 and Figure 1 show that within 14…”

Section: Organoleptic Testingmentioning

confidence: 99%

“…13 Paracetamol contains the amide group, which may be sensitive to hydrolysis degradation. 14 Hydrolysis takes place in labile carbonyl function groups, which include amides, esters, arylamines, imides, imines alcohols, and carbamates. 15 During the storage process, hydrolysis degradation of Paracetamol may occur and produce p-aminophenol, which is stated to be a very toxic substance and has the ability to cause nephrotoxicity, teratogenicity, and methemoglobinemia.…”

Section: Increased Paracetamol Contentmentioning

confidence: 99%

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Stability Testing of Compounding Capsule Combination between Paracetamol and Tramadol in a Private Hospital Semarang

Kurniawan

Gani

Yuliani

2020

JFAPS

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A combination of Paracetamol and Tramadol is used in mild to severe pain management. In a private Hospital Semarang, this combination is included in fast-moving drugs that it is frequently compounded and prepared in advance. The study aims to determine Beyond Use Date (BUD) in compounding capsules combination between Paracetamol and Tramadol samples. Beyond Use Date is a time limit indicating that a medicine beyond the expiration date must not be used and determined based on the results of stability testing. Samples were stored for 14 days in a tightly closed container far from direct sunlight in room temperature without AC (28 0 C) and without silica gel, room temperature with AC (25 0 C) without silica gel, and room temperature with AC (25 0 C) with silica gel. Furthermore, samples underwent physical and chemical stability testing. Physical stability testing was conducted using organoleptic testing by observing direct changes from the powder color in capsules, capsules form, and scent on the samples. Meanwhile, chemical stability testing was conducted by determining the content of active ingredient from the samples using reversed-phase HPLC method and C18 as the stationary phase, methanol and aquabidest (40:60) as the mobile phase, wavelength 271 nm, flow rate 0.6 mL/min and injection volume 10 μL. The result shows that samples were physically stable for being able to retain the original physical properties showed by consistent powder color and capsules form, and there was no available scent. However, the chemical stability testing method was unable to separate and quantify the content of Paracetamol, Tramadol, and formed degradation products. It can be concluded that Beyond Use Date based on organoleptic and chemical stability testing for 14 days of compounding capsules combination between Paracetamol and Tramadol could not be determined. Nevertheless, this study showed favorable storage conditions in a tightly closed container far from direct sunlight in Room Temperature with AC (25 0 C) with Silica Gel.

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“…This test is carried out to identify the physical stability of the compounded preparation and to establish a Beyond Use Date. Table 1 and Figure 1 show that within 14…”

Section: Organoleptic Testingmentioning

confidence: 99%

Section: Increased Paracetamol Contentmentioning

confidence: 99%

Stability Testing of Compounding Capsule Combination between Paracetamol and Tramadol in a Private Hospital Semarang

Kurniawan

Gani

Yuliani

2020

JFAPS

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“…Other scientists have analyzed the rate of degradation of paracetamol and ascorbic acid in a mixture of a ready-made preparation, a mixture prepared ex tempore from ingredients and individual substances. The greatest durability was shown for the mixture of the commercial product, probably due to the used preservatives [31].…”

Section: Introductionmentioning

confidence: 99%

Stability Study of Selected Coxibs Used in the Treatment of Rheumatoid Diseases in Various Drug Combinations

Gumułka,

Dąbrowska,

Starek

2023

Processes

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Coxibs are a group of non-steroidal anti-inflammatory drugs (NSAIDs), selective cyclooxygenase 2 inhibitors, characterized by a much lower gastrotoxicity compared to classic NSAIDs. They are often used in conjunction with other drugs, which greatly increases the likelihood of adverse drug interactions. The presented study analyzed the degradation rate of celecoxib and cimicoxib in solutions under the influence of other medicinal substances at different temperatures. For this purpose, triple-drug mixtures were prepared, consisting of coxib and eleven different commonly used drugs (paracetamol, ketoprofen, diclofenac, acetylsalicylic acid, ibuprofen, meloxicam, tramadol, doxycycline, bisoprolol, and caffeine). Then, the mixtures were incubated at two temperatures. Within the time specified by the research plan, further aliquots of the mixtures were subjected to a chromatographic analysis. Separation was conducted on HPTLC F254 silica gel chromatographic plates as a stationary phase, using chloroform: acetone: toluene as a mobile phase, and was detected densitometrically at wavelengths of 254 nm. The percentage changes in the tested coxibs content, depending on the time and conditions of incubation, were presented. Based on the obtained data, the basic kinetic parameters of the degradation processes were determined. The celecoxib and cimicoxib showed a relatively high durability in changing environmental conditions. It was observed that the rate of decomposition of cimicoxib and celecoxib in the tested mixtures was different and depended on the temperature and presence of other components, with cimicoxib turning out to be a more stable compound.

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A promising protected ascorbic acid-hydroxyapatite nanocomposite as a skin anti-ager: A detailed photo-and thermal stability study

Sliem

Karas

Harith

2017

Journal of Photochemistry and Photobiology B: Biology

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Stability Studies of a Mixture of Paracetamol and Ascorbic Acid, Prepared Extempore, at Elevated Temperature and Humidity Conditions

Cited by 5 publications

References 22 publications

Stability Testing of Compounding Capsule Combination between Paracetamol and Tramadol in a Private Hospital Semarang

Stability Testing of Compounding Capsule Combination between Paracetamol and Tramadol in a Private Hospital Semarang

Stability Study of Selected Coxibs Used in the Treatment of Rheumatoid Diseases in Various Drug Combinations

A promising protected ascorbic acid-hydroxyapatite nanocomposite as a skin anti-ager: A detailed photo-and thermal stability study

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