Stability study of dezocine in 0.9% sodium chloride solutions for patient-controlled analgesia administration

Fang, Baoxia; Wang, Linhai; Liu, Huimin; Chen, Fuchao; Liu, Jing

doi:10.1097/md.0000000000007979

Cited by 6 publications

(5 citation statements)

References 7 publications

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“…[26] It has been demonstrated that dezocine is stable for at least 1 week in 5% dextrose injection or 0.9% sodium chloride injection at room temperature. [17] No loss of dezocine was found in the previous studies during the testing. The studies also reported that most of the other tested drugs, such as ketorolac tromethamine, droperidol, fentanyl, ibuprofen and dexamethasone, were stable when combined with dezocine.…”

Section: Discussionmentioning

confidence: 90%

“…The final nominal concentrations of dezocine and tropisetron hydrochloride were 0.4 mg/mL and 0.05 mg/mL, respectively. [17,18] The selection of the concentrations of these drugs in our study was based on those used in daily practice. Three polyolefin bags and 3 glass containers containing the dezocine and tropisetron hydrochloride admixture were stored at 4°C or 25°C.…”

Section: Methodsmentioning

confidence: 99%

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Compatibility and stability of dezocine and tropisetron in 0.9% sodium chloride injection for patient-controlled analgesia administration

Chen

Zhou

2018

Medicine

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Tropisetron is an adjuvant for dezocine used in intravenous patient-controlled analgesia (PCA) and has been reported to provide superior pain control. It is efficacious in reducing the institutional incidence of postoperative nausea and vomiting (PONV), which decreases resource utilization and cost. However, no scientific evidence has been reported in the literature demonstrating analytical confirmation of the compatibility and stability of the combination of dezocine and tropisetron. Thus, the present study aimed to investigate the stability of dezocine with tropisetron in 0.9% sodium chloride injection form for PCA administration.Commercial solutions of dezocine and tropisetron were combined and examined for compatibility and stability when diluted with 0.9% sodium chloride injection in polyolefin bags and glass bottles stored at 4°C or 25°C for up to 14 days. The initial concentrations were 40 mg/100 mL dezocine and 5 mg/100 mL tropisetron. For all samples, the compatibility parameters (including precipitation, cloudiness, discoloration, and pH values) were evaluated. Chemical stability was also determined using high-performance liquid chromatographic (HPLC) analysis.After a 14-day period of storage at 4°C or 25°C, the initial concentrations of dezocine and tropisetron were maintained at at least 98%. All of the mixtures remained clear and colorless throughout the observation period, and no color change or precipitation was observed.These results indicated that admixtures of 40 mg/100 mL dezocine and 5 mg/100 mL tropisetron in 0.9% sodium chloride injection were stable for at least 14 days when stored in polyolefin bags or glass bottles at 4°C or 25°C and protected from light.

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Section: Discussionmentioning

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Compatibility and stability of dezocine and tropisetron in 0.9% sodium chloride injection for patient-controlled analgesia administration

Chen

Zhou

2018

Medicine

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“…Fang et al discovered that dezocine was stable for 3 days at room temperature (25 °C) and for up to 14 days at refrigerated temperature (4 °C) in NS for PCA administration. [18] In addition, Hu et al indicated that the mixture of dezocine injection and ketorolac tromethamine in NS was stable for at least 12 hours at room Guo and Chen • Medicine (2022) www.md-journal.com temperature. [19] Chen et al confirmed that dezocine injection mixed with tropisetron hydrochloride in NS solutions was stable for up to 2 weeks, when stored at refrigerated or room temperatures.…”

Section: Discussionmentioning

confidence: 99%

Physical compatibility and chemical stability of dezocine and ramosetron in 0.9% sodium chloride injection for patient-controlled analgesia administration

Guo

Chen

2022

Medicine

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As an antiemetic, 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist (ramosetron) is generally administered to prevent and treat postoperative nausea and vomiting induced by intravenous dezocine for patient-controlled analgesia. To date, the physicochemical stability of dezocine-ramosetron admixtures has not been assessed. The primary objective of this study was to evaluate the physicochemical stability of a combination of dezocine and ramosetron in 0.9% sodium chloride (normal saline [NS]) injections. Dezocine-ramosetron admixtures were prepared and stored in glass bottles and polyvinyl chloride (PVC) bags refrigerated at 4°C or stored at ambient temperatures (25°C) for up to 14 days. Initial concentrations were 5.0 mg/100 mL for dezocine and 0.3 mg/100 mL for ramosetron used as the diluents. Stability parameters (drug concentrations and pH values) were determined using high-performance liquid chromatography and pH measurements, respectively. Compatibility (cloudiness, discoloration, and precipitation) was assessed visually. After 14 days at 4 °C or 25 °C, the concentration losses of dezocine and ramosetron were both < 4%. Furthermore, there were no significant changes in color, turbidity, or pH values were observed in any of the batches. The results indicated that mixtures of dezocine and ramosetron in NS injections were continuously physically and chemically stable for 14 days in glass bottles or PVC bags stored at 4 °C or 25 °C.

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“…Due to the side effects of these drugs, it is necessary to develop a safe and effective analgesic method. Dezocine is a partial opiate drug and is used for pain management [7]. It is a newly synthesized opioid κ receptor partial agonist with a structure similar to pentazocine.…”

Section: Effect Of Dizocine Combined With Ropivacaine Recurrent Neuromentioning

confidence: 99%

Analgesic Effect of Dizocine Combined with Ropivacaine on Recurrent Neuropathic Pain in Peripheral Nerve Compression Rats

Xiao

Chu

et al. 2019

Pharmacology

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To explore the analgesic effect of dizocine combined with ropivacaine on recurrent neuropathic pain in rat model of peripheral nerve compression. Rats were randomly divided into 5 groups: sham control group (S), peripheral nerve compression model group (M), dizocine group (D), ropivacaine group (R), and combined drug group (DR). Rat peripheral nerve compression model was constructed to observe the symptoms of the rats before and after surgery. Mechanical withdrawal threshold was measured on the 21st day after surgery. The electrophysiological changes of rat peripheral nerve were measured by biopotential recording system, including proximal latency, distal latency, and compound muscle action potential. The incubation period and nerve conduction velocity were further obtained. Histological changes were observed by HE staining and toluidine blue staining. Axon number and myelin damage grade were performed, and the ultrastructure was observed by transmission electron microscopy (TEM). The mechanical withdrawal threshold, nerve conduction velocity, and compound muscle action potential were effectively increased in combination group. However, the proximal latency, distal latency, and incubation period were significantly reduced. Furthermore, dizocine combined with ropivacaine can effectively reduce the degree of myelination. TEM shown that the DR group had the best therapeutic effect, and the histological appearance of the cross section was quite similar to that of the S group. Dizocine combined with ropivacaine has a significant analgesic effect in rat model of peripheral nerve compression.

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Stability study of dezocine in 0.9% sodium chloride solutions for patient-controlled analgesia administration

Cited by 6 publications

References 7 publications

Compatibility and stability of dezocine and tropisetron in 0.9% sodium chloride injection for patient-controlled analgesia administration

Compatibility and stability of dezocine and tropisetron in 0.9% sodium chloride injection for patient-controlled analgesia administration

Physical compatibility and chemical stability of dezocine and ramosetron in 0.9% sodium chloride injection for patient-controlled analgesia administration

Analgesic Effect of Dizocine Combined with Ropivacaine on Recurrent Neuropathic Pain in Peripheral Nerve Compression Rats

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