Stability Study of Parenteral N-Acetylcysteine, and Chemical Inhibition of Its Dimerization

Primas, Nicolas; Lano, Guillaume; Brun, Damien; Curti, Christophe; Sallée, Marion; Sampol-Manos, Emmanuelle; Lamy, Elsa; Bornet, Corinne; Burtey, Stéphane; Vanelle, Patrice

doi:10.3390/ph16010072

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Extending the scope beyond the aforementioned substrates, the protocol effectively facilitated the conversion of ploy-aromatic (2u) and heteroaromatic (2v and 2w) thiols into their respective disulfides. To underscore the practical utility of this approach, we have employed it in the oxidation of bioactive thiols, namely N-(tert-butoxycarbonyl)-L-cysteine methyl ester 1x and N-acetyl-L-cystine 1y (Figure 3), which have been used as treatments for acute paracetamol toxicity and peptide synthesis, respectively [35,36]. This resulted in the formation of the corresponding disulfides 2x and 2y in 66% and 98% yields, respectively.…”

Section: Resultsmentioning

confidence: 99%

Application of Iodine as a Catalyst in Aerobic Oxidations: A Sustainable Approach for Thiol Oxidations

Wang,

Chen,

Qin

et al. 2023

Molecules

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Iodine is a well-known oxidant that is widely used in organic syntheses. Thiol oxidation by stoichiometric iodine is one of the most commonly employed strategies for the synthesis of valuable disulfides. While recent advancements in catalytic aerobic oxidation conditions have eliminated the need for stoichiometric oxidants, concerns persist regarding the use of toxic or expensive catalysts. In this study, we discovered that iodine can be used as a cheap, low-toxicity catalyst in the aerobic oxidation of thiols. In the catalytic cycle, iodine can be regenerated via HI oxidation by O2 at 70 °C in EtOAc. This protocol harnesses sustainable oxygen as the terminal oxidant, enabling the conversion of primary and secondary thiols with remarkable efficiency. Notably, all 26 tested thiols, encompassing various sensitive functional groups, were successfully converted into their corresponding disulfides with yields ranging from >66% to 98% at a catalyst loading of 5 mol%.

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Section: Resultsmentioning

confidence: 99%

Application of Iodine as a Catalyst in Aerobic Oxidations: A Sustainable Approach for Thiol Oxidations

Wang,

Chen,

Qin

et al. 2023

Molecules

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“…The data showed that NAC was stable for 420 days when stored at 2–8, 18–25 and 40°C (To et al, 2008). Stability of parenteral dosage forms of NAC was evaluated at 25 ± 2°C and under refrigeration conditions (5 ± 3°C) for 8 days (Primas et al, 2023). The results showed that 25 mg/ml NAC, diluted with 5% dextrose in water and placed in a polymeric Viaflo® bag, was stable for 24 h at room temperature and 4 days under refrigeration conditions.…”

Section: Discussionmentioning

confidence: 99%

“…The data showed that NAC was stable for 420 days when stored at 2-8, 18-25 and 40 C (To et al, 2008). Stability of parenteral dosage forms of NAC was evaluated at 25 ± 2 C and under refrigeration conditions (5 ± 3 C) for 8 days (Primas et al, 2023). The results…”

Section: Calibration Curvesmentioning

confidence: 99%

LC–MS/MS determination of N‐acetyl‐l‐cysteine in chicken plasma

Roydeva,

Milanova

2024

Biomedical Chromatography

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N‐acetyl‐l‐cysteine (NAC) shows beneficial effects in cases of aflatoxicosis and heat stress in poultry but little is known about its pharmacokinetics in chickens. Therefore, the study aimed to develop and validate a sensitive LC–MS/MS analytical method for quantitative analysis of NAC in chicken plasma. A split calibration curve approach was used for determination of NAC in chicken plasma. Standard curves for low (0.05–2.5 μg/ml) and high (2.5–100 μg/ml) ranges of concentrations were prepared. The standard curves for low (r2 = 0.9987) and high (r2 = 0.9899) concentrations were linear within the tested range. The limits of detection (LOD) and of quantification (LOQ) for the standard at low concentrations were 0.093 and 0.28 μg/ml, respectively. The accuracy was from 97.35 to 101.33%. The values of LOD and LOQ for the standard at high concentrations were 0.76 and 2.30 μg/ml, respectively. The accuracy was between 99.77 and 112.14%. The intra‐ and inter‐day precisions for all concentrations from both standards did not exceed 8.57% and 10.69%, respectively. The recovery for all concentrations was between 92.45 and 105.52%. The validated method for determination of NAC in chicken plasma can be applied in future pharmacokinetic studies in chickens without dilution of samples and their repeated analysis.

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A green sustainable approach for the determination of a complex quintet hepatoprotective mixture using dual wavelength HPLC coupled with diode array detection: Compliance with greenness and whiteness metrics

Ashour

Kamel

El‐Yazbi

et al. 2023

Sustainable Chemistry and Pharmacy

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Stability Study of Parenteral N-Acetylcysteine, and Chemical Inhibition of Its Dimerization

Cited by 4 publications

References 13 publications

Application of Iodine as a Catalyst in Aerobic Oxidations: A Sustainable Approach for Thiol Oxidations

Application of Iodine as a Catalyst in Aerobic Oxidations: A Sustainable Approach for Thiol Oxidations

LC–MS/MS determination of N‐acetyl‐l‐cysteine in chicken plasma

A green sustainable approach for the determination of a complex quintet hepatoprotective mixture using dual wavelength HPLC coupled with diode array detection: Compliance with greenness and whiteness metrics

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