2023
DOI: 10.1002/ange.202310655
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Stabilization and Binding of [V4O12]4− and Unprecedented [V20O54(NO3)]n− to Lysozyme upon Loss of Ligands and Oxidation of the Potential Drug VIVO(acetylacetonato)2

Giarita Ferraro,
Gabriella Tito,
Giuseppe Sciortino
et al.

Abstract: High‐resolution crystal structures of lysozyme in the presence of the potential drug VIVO(acetylacetonato)2 under two different experimental conditions have been solved. The crystallographic study reveals the loss of the ligands, the oxidation of VIV to VV and the subsequent formation of adducts of the protein with two different polyoxidovanadates: [V4O12]4–, which interacts with lysozyme non‐covalently, and the unprecedented [V20O54(NO3)]n–, which is covalenty bound to the side chain of an aspartate residue o… Show more

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