Stabilization and multidose use of exametazime for cerebral perfusion studies

Solanki, Chandra K.; Dj, Li; Wong, Alex Mun-Ching; Rw, Barber; Ep, Wraight; Cb, Sampson

doi:10.1097/00006231-199409000-00009

Cited by 8 publications

(3 citation statements)

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“…Recently, the kinetics of this decomposition were studied in detail by Ding et al (7). Although a number of procedures for stabilization of the compound have been published during the last years (3,4,13,24,26,27), no data on the influence of stabilization of the complex on image quality are available to date.…”

Section: Discussionmentioning

confidence: 99%

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Improvement of Brain SPECT by Stabilization of Tc-99m-HMPAO with Methylene Blue or Cobalt Chloride

Barthel

Kämpfer²,

Seese³

et al. 1999

Nuklearmedizin

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Summary Aim: This present study was carried out to investigate whether stabilization of Tc-99m-HMPAO with methylene blue (MB) or cobalt chloride (CC) causes a sensible improvement in image quality and how cerebral to noncerebral activity ratios compare with those of Tc-99m-ECD. Methods: 30 minutes after preparation 400-600 MBq unstabilized Tc-99m-HMPAO (N = 35 patients), Tc-99m-HMPAO added with MB (N = 24 patients), added with CC (N = 30 patients) or Tc-99m-ECD (N = 28 patients) were injected. Radiochemical stability was measured in vitro with three chromatographical methods. Image quality was assessed quantitatively using two ratios, one of them determined by count densities of brain/scalp (QS), the other one by count densities of brain/ nose (QN). In addition, image quality (0 = bad, 3 = excellent) and background activity (0 = high, 3 = no) were visually assessed by three independent observers. Results: In contrast to unstabilized Tc-99m-HMPAO the integrity of the complexes of MB-Tc-99m-HMPAO, CC-Tc-99m-HMPAO and Tc-99m-ECD decreased only by a few percent during a period of 2 hours after reconstitution (66.8 ± 9.9 vs. 93.0 ± 2.5, 91.8 ± 1.9 and 96.9 ± 1.4%, p <0.001). Qs and Qn (m.v. ± SD) differed significantly between studies using unstabilized Tc-99m-HMPAO (3.0 ± 0.4 and 2.1 ± 0.3), MB-Tc-99m-HMPAO (3.4 ± 0.4 and 2.3 ± 0.3), CC-Tc-99m-H M PAO (3.6 ± 0.6 and 2.6 ± 0.4) and those using Tc-99m-ECD (4.3 ± 0.7 and 4.8 ± 1.4; p <0.05 and <0.001). Stabilization with CC or MB resulted in significant higher scoring of image quality and lower scoring of background activity in comparison to that of unstabilized Tc-99m-HMPAO, without reaching the scores obtained with Tc-99m-ECD. Conclusions: It is concluded that stabilization of Tc-99m-HMPAO with MB or CC definitely improves image quality in rCBF-SPECT, without reaching that of Tc-99m-ECD. Improvement of image quality results from the reduction of the amount of decomposition products that contribute to considerable extracerebral activity.

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Section: Discussionmentioning

confidence: 99%

“…By this agent the shelf life of the compound was increased to approximately 2 h (13,14). The addition of ethanol (3,4,24) or stannous fluoride (26) to the HMPAO complex resulted in a less consistent increase of in vitro stability (27).…”

Section: Nuklearmedizin 1999; 38: 80-4mentioning

confidence: 99%

Improvement of Brain SPECT by Stabilization of Tc-99m-HMPAO with Methylene Blue or Cobalt Chloride

Barthel

Kämpfer²,

Seese³

et al. 1999

Nuklearmedizin

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“…Stabilization of the 99m Tc-HMPAO primary complex is required due to the high degradation rate of its radiochemical purity. This could be achieved by adding stabilizers like methylene blue in phosphate buffer or cobalt (II)-chloride to the reaction vials [64], however, these reagents should not be used when the complex formulation is designed for labeling of leukocytes.…”

Section: Radiopharmaceuticalsmentioning

confidence: 99%

Molecular SPECT Imaging: An Overview

Khalil

Tremoleda

Bayomy

et al. 2011

International Journal of Molecular Imaging

224

138

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Molecular imaging has witnessed a tremendous change over the last decade. Growing interest and emphasis are placed on this specialized technology represented by developing new scanners, pharmaceutical drugs, diagnostic agents, new therapeutic regimens, and ultimately, significant improvement of patient health care. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) have their signature on paving the way to molecular diagnostics and personalized medicine. The former will be the topic of the current paper where the authors address the current position of the molecular SPECT imaging among other imaging techniques, describing strengths and weaknesses, differences between SPECT and PET, and focusing on different SPECT designs and detection systems. Radiopharmaceutical compounds of clinical as well-preclinical interest have also been reviewed. Moreover, the last section covers several application, of μSPECT imaging in many areas of disease detection and diagnosis.

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Technetium-99m Radiopharmaceuticals

Saleh

2010

Basic Sciences of Nuclear Medicine

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Stabilization and multidose use of exametazime for cerebral perfusion studies

Cited by 8 publications

References 0 publications

Improvement of Brain SPECT by Stabilization of Tc-99m-HMPAO with Methylene Blue or Cobalt Chloride

Improvement of Brain SPECT by Stabilization of Tc-99m-HMPAO with Methylene Blue or Cobalt Chloride

Molecular SPECT Imaging: An Overview

Technetium-99m Radiopharmaceuticals

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