In this paper, we consider boundary stabilization problem of heat equation with multi-point heat source. Firstly, a state feedback controller is designed mainly by backstepping approach. Under the designed state controller, the exponential stability of closed-loop system is guaranteed. Then, an observer-based output feedback controller is proposed. We prove the exponential stability of resulting closed-loop system using operator semigroup theory. Finally, the designed state and output feedback controllers are effective via some numerical simulations.