2003
DOI: 10.1523/jneurosci.23-08-03538.2003
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Stabilization of Bursting in Respiratory Pacemaker Neurons

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Cited by 79 publications
(101 citation statements)
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“…The main findings of our study are in full accordance with previous reports that showed reconfigurations of in vitro network activity after blockade of inhibitory neurotransmission [36], including the loss of phasic inhibition in expiratory-like neurones [49] and recruitment of additional inspiratory-like pacemaker neurones [50]. In summary, the present data set supports the hypothesis that excitatory and inhibitory coupling between RTN/pFRG and pre-BötC [16,30] is an essential mechanism for respiratory rhythm generation.…”
Section: Technical Considerationssupporting
confidence: 93%
“…The main findings of our study are in full accordance with previous reports that showed reconfigurations of in vitro network activity after blockade of inhibitory neurotransmission [36], including the loss of phasic inhibition in expiratory-like neurones [49] and recruitment of additional inspiratory-like pacemaker neurones [50]. In summary, the present data set supports the hypothesis that excitatory and inhibitory coupling between RTN/pFRG and pre-BötC [16,30] is an essential mechanism for respiratory rhythm generation.…”
Section: Technical Considerationssupporting
confidence: 93%
“…In addition, the following antagonists of fast excitatory and inhibitory transmission were used: 100 M D-(Ϫ)-2-amino-5-phosphonopentanoic acid (D-AP5; an NMDA receptor antagonist; Tocris Bioscience), 20 -100 M 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; a nonNMDA receptor antagonist; Tocris Bioscience), 10 M bicuculline methiodide (a GABA A receptor antagonist; Sigma-Aldrich), and 10 M strychnine (a glycine receptor antagonist; Tocris Bioscience). The drug concentrations and the application time were similar to those used in previous studies (Bongianni et al, 1999(Bongianni et al, , 2002(Bongianni et al, , 2006Aberger et al, 2001;Le Ray et al, 2003Shao and Feldman, 2002;Tryba et al, 2003;Peña et al, 2004;Del Negro et al, 2005;Lorier et al, 2007;Shao et al, 2008;St. John and Leiter, 2008;Mutolo et al, 2010).…”
Section: Methodssupporting
confidence: 78%
“…Unexpectedly, preliminary experiments performed on lampreys in an attempt to ascertain the presence of respiratory neurons with pacemaker properties (Tryba et al, 2003;Peña et al, 2004;Del Negro et al, 2005) by blocking ionotropic glutamate (Glu) receptors (iGluRs) as well as GABA A and glycine receptors showed that respiratory rhythmic activity, although at reduced frequency, persisted. This finding prompted us to further investigate this intriguing issue.…”
Section: Introductionmentioning
confidence: 99%
“…In the rhythmically active network, bursting neurons are bombarded by synaptic inhibition not only during the expiratory phase, but also during inspiration [112]. As a consequence, bursting in some, but not all, bursting neurons, is suppressed during inspiration [113]. Thus, the degree of bursting within the respiratory network depends in part on synaptic inhibition, which is modulated by numerous conditions.…”
Section: The Synaptic Determinants Of Respiratory Rhythmsmentioning
confidence: 99%
“…Moreover, numerous studies demonstrate that various forms of autonomous pacemaker activity exist within the preBötC [23,25,26,33,113,123]. Thus, aside from theoretical considerations of extreme conditions, it would almost be a miracle if the abundance of autonomous activity would simply go away during the emergence of the respiratory rhythm.…”
Section: The Synaptic Determinants Of Respiratory Rhythmsmentioning
confidence: 99%