Stabilization of pulmonary mitochondrial enzyme system by capsaicin during benzo(a)pyrene induced experimental lung cancer

Anandakumar, Pandi; Kamaraj, S.; Jagan, Sundaram; Ramakrishnan, G.; Vinodhkumar, Radhakrishnan; Devaki, Thiruvengadam

doi:10.1016/j.biopha.2007.09.005

Cited by 31 publications

(21 citation statements)

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“…twice weekly for 4 weeks increased lysosomal enzyme activities and oxidative stress, altered phase I and II enzymes, increased serum tumor markers, changed body weight, and tumor incidences Capsaicin (10 mg/kg, i.p.) 1 week prior to first BP dose for 14 weeks generally reversed all reported BP-induced changes, attenuated abnormalities and restored normal values Anandakumar et al 2008;Anandakumar et al 2008aAnandakumar et al , 2008bAnandakumar et al2009aAnandakumar et al , 2009b; Anandakumar, P., Kamaraj, S., Jagan, S., Ramakrishnan, G., Naveenkumar, et al 2009 B6 mice DMBA-initiated and TPA-promoted TRPV1 WT mice showed more tumors than KO mice DMBA-initiated mice showed no tumors with topical capsaicin applications Capsaicin co-administration enhanced TPA-promoted tumors Bode et al 2009;Hwang et al 2010 papillary or nodular hyperplasia of the urinary bladder. Incidences of carcinogen-induced lesions of the thyroid and kidney were not significantly altered by capsaicin.…”

Section: Teel and Huynh 1999mentioning

confidence: 91%

“…At the termination of the study (38 weeks), capsaicin feeding during either the initiation or promotion phase reduced the frequency of tongue squamous cell papillomas and squamous cell carcinomas (NQO alone, 9/15 rats with tongue tumors; NQO plus 10 weeks capsaicin, 5/17 rats with tongue tumors [not significant]; NQO plus 28 weeks of capsaicin, 3/14 rats with tongue tumors [p<0.05]). In a series of closely related experiments using Swiss albino mice, capsaicin was shown to exert its chemoprotective effects via several different mechanisms against benzo(a)pyrene (BP)-induced lung cancer (Anandakumar et al 2008;Anandakumar et al 2008aAnandakumar et al , 2008bAnandakumar et al2009aAnandakumar et al , 2009b; Anandakumar, P., Kamaraj, S., Jagan, S., Ramakrishnan, G., Naveenkumar, et al 2009). Due to the closely related nature of methods and somewhat overlapping results, key results from all 8 publications are grouped into one entry in Table 4.…”

Section: Teel and Huynh 1999mentioning

confidence: 99%

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A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

et al. 2012

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Human exposure to capsaicin, the most abundant pungent chili pepper component, is ubiquitous. Evaluation of capsaicin's carcinogenic potential has produced variable results in in vitro and in vivo genotoxicity and carcinogenicity assays. The capsaicin tested in older studies was often from pepper plant extracts and included other capsaicinoids and diverse impurities. Recent studies utilizing high-purity capsaicin and standardized protocols provide evidence that the genotoxic and carcinogenic potential of capsaicin is quite low and that the purity of capsaicin is important. Several small epidemiological studies suggest a link between capsaicin consumption and stomach or gall bladder cancer, but contamination of capsaicin-containing foods with known carcinogens renders their interpretation problematic. The postulated ability of capsaicin metabolites to damage DNA and promote carcinogenesis remains unsupported. Anticancer activities of capsaicin have been widely reported, as it inhibits the activity of carcinogens and induces apoptosis in numerous cancer cell lines in vitro and explanted into rodents. Diverse mechanisms have been postulated for capsaicin's anticancer properties. One hypothesis is that inhibition of cytochrome P450 enzymes-particularly CYP2E1-retards carcinogen activation but is contradicted by the low potency of capsaicin for CYP inhibition. The potential for dietary capsaicin to act as a chemopreventative is now widely postulated.

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Section: Teel and Huynh 1999mentioning

confidence: 91%

Section: Teel and Huynh 1999mentioning

confidence: 99%

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

et al. 2012

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“…Chemoprevention experiments in mice and rats show that capsaicin abrogates carcinogenesis of the skin, colon, lung, tongue and prostate (8-11). Recent studies have explored the applications of capsaicin as a potential agent for cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Capsaicin induces apoptosis in human small cell lung cancer via the TRPV6 receptor and the calpain pathway

et al. 2014

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Capsaicin, the pungent ingredient of chili peppers, displays potent anti-neoplastic activity in a wide array of human cancer cells. The present manuscript examines the signaling pathways underlying the apoptotic activity of capsaicin in human small cell lung cancer (SCLC) in vitro and in vivo. Studies in neuronal cells show that capsaicin exerts its biological activity via the transient receptor potential vanilloid (TRPV) superfamily of cation-channel receptors. The TRPV family is comprised of six members (TRPV1-6). Capsaicin is an agonist of the TRPV1 receptor. We observed that capsaicin-induced apoptosis in human SCLC cells was mediated via the TRPV receptor family; however it was independent of TRPV1. Surprisingly, the apoptotic activity of capsaicin required the TRPV6 receptor. Depletion of TRPV6 receptor by siRNA methodology abolished the apoptotic activity of capsaicin in SCLC cells. Immunostaining and ELISA showed that TRPV6 receptor was robustly expressed on human SCLC tissues (from patients) and SCLC cell lines but almost absent in normal lung tissues. This correlates with our results that capsaicin induced very little apoptosis in normal lung epithelial cells. The proapoptotic activity of was mediated by the intracellular calcium and calpain pathway. The treatment of human SCLC cells with capsaicin induced increased the activity of calpain 1 and 2 by three-fold relative to untreated SCLC cells. Such calpain activation, in response to capsaicin, was downstream of the TRPV6 receptor. Taken together, our data provide insights into the mechanism underlying the apoptotic activity of capsaicin in human SCLCs.

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“…Earlier reports state that supplementation of natural antioxidants were proven to be an excellent prevention strategy for many diseases, including diabetes liver injury, liver fibrosis, cancer and ageing. [28][29][30][31][32] Natural antioxidants curcumin, capsaicin and their combined form prevented the LPS induced hepatotoxicity in mice model. Administration of curcumin (20 mg/kg b.w.)…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Curcumin and Capsaicin against Lipopolysaccharide Induced Liver Damage in Mice

Vasanthkumar¹,

Hanumanthappa²,

Hanumanthappa³

2017

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Objective: The present study was undertaken to evaluate the possible ameliorative role of curcumin, capsaicin and their combination against lipopolysaccharide (LPS) induced hepatic toxicity in mice. Methods: Animals were distributed into five experimental groups: Normal control, vehicle control, curcumin, capsaicin and combined curcumin and capsaicin treatment groups respectively, for 7 days prior to LPS induced liver toxicity (3 mg/kg b.w. in saline). Hepatoprotective effect of individual and combined spice principles were evidenced by the measurement of serum marker enzyme activities such as, SGPT, ALP and TB and it was further confirmed by histopathological observation of liver tissue section. Results: The administration of LPS increased serum nonspecific enzymes (SGOT; 174.2±3.79 IU/L, SGPT; 124.0±3.14 IU/L, ALP; 320.15±3.88 IU/L and total bilirubin level; 2.32±1.23 mg/dL), however dietary curcumin and capsaicin decreased the activities of these non-specific serum enzymes including total bilirubin indicating amelioration of the severe LPS induced hepatotoxicity, while the combined spice principles were more significant as shown by the levels of enzymes activities SGOT; 89.9±1.39 IU/L, SGPT; 85.9±1.83 IU/L, ALP; 138.4±2.05 IU/L including total bilirubin level; 0.86±0.03 mg/dL. Conclusion: Dietary curcumin and capsaicin individually are protective to LPS induced hepatotoxicity, the beneficial effect was found to be more when the two compounds were fed in combination.

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Stabilization of pulmonary mitochondrial enzyme system by capsaicin during benzo(a)pyrene induced experimental lung cancer

Cited by 31 publications

References 41 publications

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

Capsaicin induces apoptosis in human small cell lung cancer via the TRPV6 receptor and the calpain pathway

Hepatoprotective Effect of Curcumin and Capsaicin against Lipopolysaccharide Induced Liver Damage in Mice

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