Stabilized antioxidative plant extracts formulated by liquisolid technique

Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form

“…Although LSSs are mainly used to increase the solubility and dissolution of lipophilic substances, tablets with a high content of hydrophilic substances, such as plant extracts, can also be prepared. This claim is supported by a study by Kurhajec et al, where Neusilin ® was successfully used with plant extracts by modified LSS technology [1]. The difference with conventional LSSs was that an aqueous or ethanolic solution with a concentrated plant extract was used instead of a drug dissolved in a water-miscible liquid.…”

“…MW led to tablets with higher friability and longer disintegration. All tablets were characterized by rapid disintegration and dissolution, contributing to optimal conditions for immediate drug release and the extracts' better bioavailability [1].…”

“…It evaluates the antioxidant activity of all used drugs with FRAP (ferric reduction antioxidant power assay). For the mutual comparison, the evaluations are performed by the same methods using the same equipment and conditions as in the previous work [1].…”

“…Vacuum concentrated plant extracts were prepared by long-term maceration (7 days) with ethanol (50% w/w) as an extracting agent by the same procedure described in the study of Kurhajec et al [1].…”

“…The work demonstrated the technological possibilities of preparation on a limited number of model extracts. A more comprehensive study of whether the technology itself affects AA and whether AA was retained concerning different plant species was necessary due to significant differences in the composition of each extract (Table 1) [1]. The first work was focused mainly on plant materials; this work focuses on the theoretical justification of the porous material used.…”