Stabilized Polymer Microparticles by Precipitation with a Compressed Fluid Antisolvent. 1. Poly(fluoro acrylates)

Mawson, Simon D.; Johnston, Keith P.; Betts, D. E.; McClain, J. B.; DeSimone, Joseph M.

doi:10.1021/ma961048t

Cited by 67 publications

(71 citation statements)

References 38 publications

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“…[29][30][31][32][33][34][35] It is well known that some compressed gases, such as CO 2 , are quite soluble in many organic solvents and they can reduce the solvent strengths to such a degree that the solutes can be precipitated. [36][37][38] Our previous work showed that compressed CO 2 and ethylene can increase the solubilization capacity of water in sodium bis-2-ethylhexylsulfosuccinate (AOT) and Triton X-100 reverse-micellar systems at suitable pressures because the gases can insert into the interfacial region to enhance the rigidity of the interface layers and reduce the interdroplet attraction. [39][40][41] The tuning and control of the properties of micellar solutions with compressed CO 2 is a very interesting topic.…”

Section: Introductionmentioning

confidence: 99%

Effect of Compressed CO₂ on the Critical Micelle Concentration and Aggregation Number of AOT Reverse Micelles in Isooctane

Chen¹,

Zhang²,

Han³

et al. 2006

Chemistry A European J

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The effect of compressed CO2 on the critical micelle concentration (cmc) and aggregation number of sodium bis-2-ethylhexylsulfosuccinate (AOT) reverse micelles in isooctane solution was studied by UV/Vis and fluorescence spectroscopy methods in the temperature range of 303.2-318.2 K and at different pressures or mole fractions of CO2 (X(CO2)). The capacity of the reverse micelles to solubilize water was also determined by direct observation. The standard Gibbs free energy (DeltaGo(m)), standard enthalpy (DeltaHo(m)), and standard entropy (DeltaSo(m)) for the formation of the reverse micelles were calculated by using the cmc data determined. It was discovered that the cmc versus X(CO2) curve and the DeltaGo(m) versus X(CO2) curve for a fixed temperature have a minimum, and the aggregation number and water-solubilization capacity of the reverse micelles reach a maximum at the X(CO2) value corresponding to that minimum. These results indicate that CO2 at a suitable concentration favors the formation of and can stabilize AOT reverse micelles. A detailed thermodynamic study showed that the driving force for the formation of the reverse micelles is entropy.

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Section: Introductionmentioning

confidence: 99%

Effect of Compressed CO₂ on the Critical Micelle Concentration and Aggregation Number of AOT Reverse Micelles in Isooctane

Chen¹,

Zhang²,

Han³

et al. 2006

Chemistry A European J

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“…In addition, the process requires much lower operating temperatures, when compared to spray drying, thereby avoiding drug degradation [19]. There have been numerous studies using PCA to produce drug particles [19][20], superconductor particles [21], polymer particles [8,[14][15][22][23][24], and many other particles.…”

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confidence: 99%

“…Solutions of drugs and/or polymers were sprayed through a capillary, with CO 2 flowing cocurrently in an annular region about the capillary. Coaxial nozzles have been used in the literature in an attempt to obtain better control over the product morphology [8,13,18,[23][24].…”

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confidence: 99%

Preparation of budesonide and budesonide-PLA microparticles using supercritical fluid precipitation technology

et al. 2002

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The objective of this study was to prepare and characterize microparticles of budesonide alone and budesonide and polylactic acid (PLA) using supercritical fluid (SCF) technology. A precipitation with a compressed antisolvent (PCA) technique employing supercritical CO 2 and a nozzle with 100-µm internal diameter was used to prepare microparticles of budesonide and budesonide-PLA. The effect of various operating variables (temperature and pressure of CO 2 and flow rates of drug-polymer solution and/or CO 2 ) and formulation variables (0.25%, 0.5%, and 1% budesonide in methylene chloride) on the morphology and size distribution of the microparticles was determined using scanning electron microscopy. In addition, budesonide-PLA particles were characterized for their surface charge and drugpolymer interactions using a zeta meter and differential scanning calorimetry (DSC), respectively. Furthermore, in vitro budesonide release from budesonide-PLA microparticles was determined at 37°C. Using the PCA process, budesonide and budesonide-PLA microparticles with mean diameters of 1 to 2 µm were prepared. An increase in budesonide concentration (0.25%-1% wt/vol) resulted in budesonide microparticles that were fairly spherical and less agglomerated. In addition, the size of the microparticles increased with an increase in the drug-polymer solution flow rate (1.4-4.7 mL/min) or with a decrease in the CO 2 flow rate (50-10 mL/min). Budesonide-PLA microparticles had a drug loading of 7.94%, equivalent to ~80% encapsulation efficiency. Budesonide-PLA microparticles had a zeta potential of -37 ± 4 mV, and DSC studies indicated that SCF processing of budesonide-PLA microparticles resulted in the loss of budesonide crystallinity. Finally, vitro drug release studies at 37°C indicated 50% budesonide release from the budesonide-PLA microparticles at the end of 28 days. Thus, the PCA process was successful in producing budesonide and budesonide-PLA microparticles. In addition, budesonide-PLA microparticles sustained budesonide release for 4 weeks.

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“…Therefore, the content of fluorinated monomers should be minimized while maintaining a reasonable surface energy (water/oil repellency). Acrylic copolymers containing perfluoroalkyl side chains have been the focus of many studies, because of the good reactivity of perfluorinated acrylate with fluorine-free acrylate and good adhesion to the matrices [13][14][15]. The fluorinated side groups in fluorinated acrylic copolymers have emerged preferentially at the coating-air surface [16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and properties of UV-curable polyurethane acrylates containing fluorinated acrylic monomer/vinyltrimethoxysilane

et al. 2015

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A series of UV-curable polyurethane acrylates containing fluorinated acrylic monomer (heptadecafluorodecyl methacrylate, PFA, 6 wt%)/ vinyltrimethoxysilane (VTMS, 0-9 wt%) [FPUA6/0, FPUA6/3, FPUA6/6 and FPUA6/9, where the numbers indicate the wt% of PFA/VTMS] were synthesized from a reactive urethane oligomer (40 wt%) and diluents (60 wt%). This study examined the effect of bulky VTMS (0-9 wt%)/bulky IBOA (34-25 wt%) weight ratio on the properties of the UV-curable polyurethane acrylates for transparent anti-fouling coating materials. In the wavelength range of 400-800 nm, the transmittance % of the FPUA film samples increased markedly up to nearly 100 % with increase in the VTMS content up to 9 wt%. As the VTMS content increased, the storage modulus/ tensile modulus/hardness of the UV-cured film samples increased significantly and the tensile strength/glass transition temperature increased a little; however, the elongation at break decreased significantly. XPS showed that the film-air surface of the UV-cured polyurethane acrylate film had a higher fluorine content than the filmdish interface indicating the gradient concentration of fluorine in the structure of the film from the film-air surface to the film-glass interface. As the VTMS content increased from 0 to 9 wt%, the surface tension of the UV-cured urethane acrylate films decreased from 17.2 to 15.9 mN/m, whereas the water/methylene iodide contact angles of the film-air surface increased significantly from 107.9/80.9°to 114.2.9/ 84.2°. These results suggest that the UV-curable polyurethane acrylate containing 9 & Han Do Kim

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Stabilized Polymer Microparticles by Precipitation with a Compressed Fluid Antisolvent. 1. Poly(fluoro acrylates)

Cited by 67 publications

References 38 publications

Effect of Compressed CO₂ on the Critical Micelle Concentration and Aggregation Number of AOT Reverse Micelles in Isooctane

Effect of Compressed CO₂ on the Critical Micelle Concentration and Aggregation Number of AOT Reverse Micelles in Isooctane

Preparation of budesonide and budesonide-PLA microparticles using supercritical fluid precipitation technology

Synthesis and properties of UV-curable polyurethane acrylates containing fluorinated acrylic monomer/vinyltrimethoxysilane

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Stabilized Polymer Microparticles by Precipitation with a Compressed Fluid Antisolvent. 1. Poly(fluoro acrylates)

Cited by 67 publications

References 38 publications

Effect of Compressed CO2 on the Critical Micelle Concentration and Aggregation Number of AOT Reverse Micelles in Isooctane

Effect of Compressed CO2 on the Critical Micelle Concentration and Aggregation Number of AOT Reverse Micelles in Isooctane

Preparation of budesonide and budesonide-PLA microparticles using supercritical fluid precipitation technology

Synthesis and properties of UV-curable polyurethane acrylates containing fluorinated acrylic monomer/vinyltrimethoxysilane

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Effect of Compressed CO₂ on the Critical Micelle Concentration and Aggregation Number of AOT Reverse Micelles in Isooctane

Effect of Compressed CO₂ on the Critical Micelle Concentration and Aggregation Number of AOT Reverse Micelles in Isooctane