Stabilizing the regionalisation of the developing vertebrate central nervous system

Pasini, Andrea; Wilkinson, David G.

doi:10.1002/bies.10085

Cited by 49 publications

(27 citation statements)

References 91 publications

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“…However, delayed induction of proto-rhombomere domains in fgf8-compromised embryos does not affect the eventual development of rhombomere compartments with sharply specified boundaries. This result is consistent with what is known about the delineation of sharp boundaries between rhombomeres, a process that occurs throughout early somitogenesis stages, when cells retain plasticity in their ability to contribute to different rhombomeres (reviewed in Pasini and Wilkinson, 2002).…”

supporting

confidence: 89%

Early requirement for fgf8 function during hindbrain pattern formation in zebrafish

Wiellette

Sive

2004

Developmental Dynamics

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Fibroblast growth factor (FGF) signaling is required for normal development of the vertebrate brain, including the isthmus and caudal regions of the hindbrain. Recent work in zebrafish has identified a requirement for the combination of fgf3 and fgf8 functions in specification of rhombomeres 5 and 6 (r5, r6), when evaluated at mid-and late somitogenesis stages. However, when examined earlier in development, during early somitogenesis stages, FGF8 alone is required to initiate r5 and r6 development. Both a mutation in fgf8 and injection of fgf8-targeted antisense morpholino-modified oligonucleotides result in suppression of genes normally expressed in r5 and r6 by the one-to two-somite stage. This expression recovers by the six-somite stage, and we propose that this recovery is a response to activation of fgf3 and to delayed accumulation of fgf8. These data demonstrate an early, nonredundant requirement for fgf8 function in hindbrain patterning.

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supporting

confidence: 89%

Early requirement for fgf8 function during hindbrain pattern formation in zebrafish

Wiellette

Sive

2004

Developmental Dynamics

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“…2 D and E) (30). Several studies of the developing brain have demonstrated that similar sets of genes are used to establish a particular anatomical region and to maintain the cell-cell relationships of the differentiated region (31). Thus, it may be that the roles of these genes in adulthood are similar to their roles during development.…”

Section: Discussionmentioning

confidence: 99%

Adult mouse brain gene expression patterns bear an embryologic imprint

Zapala

Hovatta²,

Ellison³

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

177

162

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The current model to explain the organization of the mammalian nervous system is based on studies of anatomy, embryology, and evolution. To further investigate the molecular organization of the adult mammalian brain, we have built a gene expression-based brain map. We measured gene expression patterns for 24 neural tissues covering the mouse central nervous system and found, surprisingly, that the adult brain bears a transcriptional ''imprint'' consistent with both embryological origins and classic evolutionary relationships. Embryonic cellular position along the anteriorposterior axis of the neural tube was shown to be closely associated with, and possibly a determinant of, the gene expression patterns in adult structures. We also observed a significant number of embryonic patterning and homeobox genes with region-specific expression in the adult nervous system. The relationships between global expression patterns for different anatomical regions and the nature of the observed region-specific genes suggest that the adult brain retains a degree of overall gene expression established during embryogenesis that is important for regional specificity and the functional relationships between regions in the adult. The complete collection of extensively annotated gene expression data along with data mining and visualization tools have been made available on a publicly accessible web site (www.barlow-lockhartbrainmapnimhgrant.org).database ͉ development ͉ evolution ͉ gene expression profiling ͉ inbred strains of mice T he adult nervous system achieves its mature form as the result of neuroectodermal cells committing to a specific fate and then segregating into distinct regional collectives of neurons that become fully functional through establishment of connections to other neurons. Our current understanding of brain architecture and organization is based on studies of embryology, anatomy, and evolution in which direct observation of anatomic structures was the foundation for postulated models of brain structure (1). Recent models of brain development and maturation consider relationships between different regions based on the expression of specific genes in assigning developmental origins of adult structures (2, 3). Here, we have constructed a regional gene expression atlas of the adult mouse brain and analyzed the quantitative results by using molecular classification algorithms.Genome-wide gene expression profiling is a powerful technique for deriving information about specific brain regions (4, 5). This approach has been used to measure gene expression patterns in particular regions, subregions, or cell populations in the brain (6-11). Two previous studies have analyzed gene expression differences across multiple regions of the mammalian brain by using multiple strains or species (12,13). However, the current study is the most extensive to date in terms of the number of genes and the coverage of different neural tissues. Our goal was to create a publicly accessible gene-based brain map with data sets, metadata, datab...

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“…During neural vertebrate development, it has been reported to be essential for the segmentation of the hindbrain and the formation of the zona limitans intrathalamica (Lewis, 1998, Pasini and Wilkinson, 2002, Kiecker and Lumsden, 2005. Although the exact mechanism by which adjacent regional domains acquire distinct properties in vertebrates is less clear, the underlying model extracted from Drosophila predicts that Notch pathway is differentially activated by the different expression of Delta and Serrate ligands and the modulator Fringe in adjacent territories.…”

Section: Principles Of the Notch Signaling Pathwaymentioning

confidence: 99%

Establishment of a proneural field in the inner ear

Abelló

Alsina²

2007

Int. J. Dev. Biol.

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Hair-cells, supporting cells and sensory neurons are the main specialized cell-types responsible for mechanotransduction in the inner ear. They derive from precursors expressing proneural genes and recent data has underlined the importance of SoxB1 genes as upstream activators of proneural genes during cranial placode development. Here we review the steps of establishing a proneural field and propose several models for how early otic regionalization into a proneural territory is achieved.

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Stabilizing the regionalisation of the developing vertebrate central nervous system

Cited by 49 publications

References 91 publications

Early requirement for fgf8 function during hindbrain pattern formation in zebrafish

Early requirement for fgf8 function during hindbrain pattern formation in zebrafish

Adult mouse brain gene expression patterns bear an embryologic imprint

Establishment of a proneural field in the inner ear

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