Stable and biocompatible hydrogel composites based on collagen and dialdehyde carboxymethyl cellulose in a biphasic solvent system

Yang, Huan; Shen, Lirui; Bu, Honghong; Li, Guoying

doi:10.1016/j.carbpol.2019.114974

Cited by 28 publications

(11 citation statements)

References 39 publications

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“…Thus, in this study, we incorporated collagen type I into CPCF because it is an important component of the skin, more biocompatible compared to other natural polymers, and exhibits low antigenicity (Ramanathan et al, 2020). Results from the MTT assay revealed that CPCF had lower cytotoxicity than that of free curcumin and Cur/PCEC nanoparticles, which are consistent with those from other studies (Hu et al, 2017;Yang et al, 2019). Results from Masson's trichrome staining ( Figure 5) revealed that the new skin in animals of the CPCF group had denser collagen fibers than that of the other groups.…”

Section: Discussionsupporting

confidence: 84%

Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing

Leng

Pang

et al. 2020

Drug Delivery

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Skin repair remains a common problem in plastic surgery. Wound dressing plays an important role in promoting local skin healing and has been widely studied. This study aimed to manufacture a composite film (CPCF) containing curcumin nanoparticles, collagen, and polyvinyl alcohol (PVA) to effectively promote the healing of skin wounds. Sustained drug release from the composite film provides long-term protection and treatment for skin wounds. Both antibacterial property and good histocompatibility of the CPCF were examined by analyzing antibacterial activity and cytotoxicity to validate its applicability for wound management. Moreover, in vivo studies proved that the CPCF had a rapid healing rate of 98.03%±0.79% and mature epithelialization on day 15 after surgery. Obvious hair follicles and earlier re-epithelialization was also noticed in the CPCF group using H&E staining. The result of Masson's trichrome staining confirmed that CPCF could promote the formation of collagen fibers. In summary, CPCF may be promising as a wound dressing agent in wound management owing to its rapid wound-healing effects.

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Section: Discussionsupporting

confidence: 84%

Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing

Leng

Pang

et al. 2020

Drug Delivery

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“…Crosslinking mechanisms of collagen with Aldehydes (a) [205], Genipin (b) [206], Epoxy compounds (c) [207], NHS-activated carboxylic acid esters (d) [208], EDC/NHS (e) [209], DPPA (f) [210] and Transglutaminase (g) [ Authors' contributions GYL made substantial contributions to conception and design of this review, and critical revised the manuscript. XXZ wrote and revised the manuscript.…”

Section: Methodsmentioning

confidence: 99%

“…The complex solution of collagen and the dialdehydes might be not stable enough due to large molecular weight as well as the strong electrostatic attraction between collagen and the dialdehydes. A more stable hydrogel of collagen and DCMC with a higher concentration was prepared by Yang et al [205] using the biphasic acetic acid/1-ethyl-3methylimidazolim acetate solvent system. The Col/ DCMC solution with constant DCMC content contained different collagen concentrations of 5-25 mg/ml.…”

Section: Other Crosslinkersmentioning

confidence: 99%

Factors affecting thermal stability of collagen from the aspects of extraction, processing and modification

et al. 2020

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Collagen, as a thermal-sensitive protein, is the most abundant structural protein in animals. Native collagen has been widely applied in various fields due to its specific physicochemical and biological properties. The beneficial properties would disappear with the collapse of the unique triple helical structure during heating. Understanding thermal stability of collagen is of great significance for practical applications. Previous studies have shown the thermal stability would be affected by the different sources, extraction methods, solvent systems in vitro and modified methods. Accordingly, the factors affecting thermal stability of collagen are discussed in detail in this review.

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“…collagen (Col) 55 or gelatin 56,57 ) is common. The incorporation of Col (type I) into CS hydrogels (final concentration CS 2 w:v% -Col 0.25 w:v%) drastically improved HDF spreading and adhesion, resulting in viabilities greater than 90% for up to 6 days, while having minimum effect on BeWo (Figure 7 and It is worth noting that only a small amount of Col was needed to significantly enhance cell adhesion, while Col hydrogels typically require concentrations higher than 0.5 w:v% to achieve a good viability 58 . Lower viabilities were generally observed when CS-SH was used as a crosslinker (Figure 7).…”

Section: Resultsmentioning

confidence: 99%

Tunable Thiol–Ene Photo-Cross-Linked Chitosan-Based Hydrogels for Biomedical Applications

michel

Rogers

Briscoe

et al. 2020

ACS Appl. Bio Mater.

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Access to biocompatible hydrogels with tuneable properties is of great interest in biomedical applications. Here we report the synthesis and characterisation of a series of photocrosslinked chitosan hydrogels from norbornene-functionalised chitosan (CS-nb) and various thiolated crosslinkers. The resulting materials were characterised by NMR, swelling ratio, rheology, SEM and small angle neutron scattering (SANS) measurements. The hydrogels exhibited pH-and salt-dependent swelling, whilst the macro-and micro-scale properties could be modulated by the choice and degree of crosslinker or the polymer concentration. The materials could be moulded in situ and loaded with small molecules that can be released overtime. Moreover, the incorporation of collagen in the hydrogels drastically improved cell adhesion, with excellent viabilities of human dermofibroblast cells on the hydrogels observed for up to 6 days, highlighting the potential use of these materials in the biomedical area.

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Stable and biocompatible hydrogel composites based on collagen and dialdehyde carboxymethyl cellulose in a biphasic solvent system

Cited by 28 publications

References 39 publications

Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing

Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing

Factors affecting thermal stability of collagen from the aspects of extraction, processing and modification

Tunable Thiol–Ene Photo-Cross-Linked Chitosan-Based Hydrogels for Biomedical Applications

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