Stable and permeable polyion complex vesicles designed as enzymatic nanoreactors

Wan, Yuting; Qiu, Yuening; Zhou, Jin; Liu, Jinbo; Stuart, Martien A. Cohen; Peng, Yangfeng; Wang, Junyou

doi:10.1039/d4sm00216d

Soft Matter

2024

DOI: 10.1039/d4sm00216d

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Stable and permeable polyion complex vesicles designed as enzymatic nanoreactors

Yuting Wan,

Yuening Qiu,

Jin Zhou

et al.

Abstract: Polymeric vesicles are perspective vehicles for fabricating enzymatic nanoreactors towards diverse biomedical and catalytic applications, yet design stable and permeable vesicles remains challenge. Herein, we develop a type of polyion...

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Coassembly of Charged Copolymer Amphiphiles Featuring pH-Regulated Antifouling Properties

Banerjee,

Davis

et al. 2024

Langmuir

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Understanding the formation of highly ordered structures through self-assembly is crucial for developing various biologically relevant systems. A significant expansion in the development of self-assembly chemistry features stable coassembly formation using a mixture of two oppositely charged polymers. This study provides insightful findings on the coassembly of hydrophobic coumarinintegrated cationic (P1−P3) and anionic (P1′−P3′) copolymers toward the formation of vesicles in aqueous medium at pH 7.4, with a hydrodynamic diameter (D h ) of 160 ± 10 nm and electrically neutral zwitterionic surfaces, confirmed by dynamic light scattering. Upon varying the solution pH, an intriguing charge switchable behavior (+ve → 0 → −ve) and a drastic morphological transition to spherical aggregates of the vesicles were noticed. At pH 7.4, these coassembled vesicles possess a neutral surface charge, empowering them to resist nonspecific protein (pepsin and lysozyme) adsorption via electrostatic repulsion, as evidenced by size evolution and protein binding measurements. Additionally, the bilayer membrane allows for the encapsulation of hydrophilic and hydrophobic guest molecules and their sustained release in the presence of 10 mM esterase; thus, this study demonstrates potential applications of coassembly to serve as a drug delivery vehicle.

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Coassembly of Charged Copolymer Amphiphiles Featuring pH-Regulated Antifouling Properties

Banerjee,

Davis

et al. 2024

Langmuir

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show abstract

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Stable and permeable polyion complex vesicles designed as enzymatic nanoreactors

Abstract: Polymeric vesicles are perspective vehicles for fabricating enzymatic nanoreactors towards diverse biomedical and catalytic applications, yet design stable and permeable vesicles remains challenge. Herein, we develop a type of polyion...

Cited by 1 publication

References 44 publications

Coassembly of Charged Copolymer Amphiphiles Featuring pH-Regulated Antifouling Properties

Coassembly of Charged Copolymer Amphiphiles Featuring pH-Regulated Antifouling Properties

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