Stable aqueous dispersion of magnetic iron oxide core–shell nanoparticles prepared by biocompatible maleate polymers

Abstract

A new method is applied to prepare stable aqueous dispersion of magnetic iron oxide nanoparticles (MNPs) by biocompatible maleate polymers. Fe 3 O 4 magnetic core-shell nanoparticles are obtained via forming an inclusion complex between carboxylic acid groups of maleated biocompatible polymers shell and Fe 3 O 4 MNPs core surface. Maleate polymers are synthesized via esterification of poly(ethylene glycol), poly(vinyl alcohol) and starch with maleic anhydride (MA). The Fe 3 O 4 magnetic core-shell nanoparticles are characterized by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy and vibrating sample magnetometer. The obtained magnetic core-shell nanoparticles exhibit superparamagnetic property and reveal long-term aqueous stability. This work represents a valid methodology to produce highly stable aqueous dispersion of Fe 3 O 4 MNPs ferrofluids which can be expected to have great potential as contrast agent for magnetic resonance imaging. Furthermore, the shell composition of biocompatible maleate polymers with double bond of MA as crosslinker agent allows the polymerization with other monomers to design preferred drug delivery systems.

The Effect of Copper Loading on Iron Carbide Formation and Surface Species in Iron‐Based Fischer–Tropsch Synthesis Catalysts

“…The bands related to carboxylic species were not observed on Fe 3 O 4 ,e ven before the hydrogenation step (plot not included), suggesting that the surface of this commercial sample were not susceptible for deposition of carboxylate specieso r to form complexes,a lthough formation of carboxylate acidic group complexes with Fe 3 O 4 nanoparticles [100][101][102] has been reported.T he reference impregnatedo nF eO and Fe 2 O 3 showed weak IR bands at frequenciesc omparable to the 15/5 catalyst. It has been reported that the iron cations Fe 2 + and Fe 3 + can separately form complexes with carboxylate ligand groups.…”

Preparation ofN-Isopropylacrylamide/Itaconic Acid Magnetic Nanohydrogels by Modified Starch as a Crosslinker for Anticancer Drug Carriers

“…Starch-maleate-MNPs stable aqueous dispersion is prepared as reported previously [28]. Briefly, 100 mg of starch-maleate is dissolved in 10 mL deionized water.…”

Ion Exchange Nanoparticles for Ophthalmic Drug Delivery

“…1 H and 13 C NMR spectra (chloroform-d or dimethyl sulfoxide-d 6 ) were obtained on a Varian 300 MHz or Bruker 500 MHz NMR spectrometer in tubes with 5 mm exterior diameters. FTIR analysis was performed using a Smart iTR ATR sampling accessory for the Nicolet iS10 spectrometer with a diamond crystal [Thermo Scientific, Massachusetts, U.S.A.].…”