Stable colonization of Akkermansia muciniphila educates host intestinal microecology and immunity to battle against inflammatory intestinal diseases

Wang, Bin; Chen, Xuheng; Chen, Zhiyuan; Xiao, He; Dong, Jing; Li, Yuan; Zeng, Xiaozhou; Liu, Jinjian; Wan, Guoyun; Fan, Saijun; Cui, Ming

doi:10.1038/s12276-022-00911-z

Cited by 24 publications

(11 citation statements)

References 59 publications

(65 reference statements)

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“…Nevertheless, the therapeutic efficacy of A. muciniphila was not completely satisfactory depending on its colonization . Previous studies have shown that A.…”

Section: Discussionmentioning

confidence: 99%

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2′-Fucosyllactose Promotes Colonization of Akkermansia muciniphila and Prevents Colitis In Vitro and in Mice

Liu,

Zhang,

Zhang

et al. 2024

J. Agric. Food Chem.

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Akkermansia muciniphila is a potential candidate for ulcerative colitis prevention. Considering that it utilizes 2′fucosyllactose (2′FL) for growth, 2′FL can be used to enrich the abundance of A. muciniphila in feces. However, whether the crosswalk between 2′FL and A. muciniphila can promote the intestinal colonization of A. muciniphila remains unclear. In this study, we explored the effect and the underlying mechanism of 2′FL on the colonization of A. muciniphila in vitro and in vivo as well as its alleviating effect on colitis. Our results revealed that 2′FL can serve as a carbon source of A. muciniphila to support the growth and increase cell-surface hydrophobicity and the expression of the genes coding fibronectin-binding autotransporter adhesin to promote the adhesion to Caco2/HT29 methotrexate (MTX) cells but not of galactooligosaccharides (GOS) and glucose. Moreover, 2′FL could increase the host mucin formation to promote the adhesion of A. muciniphila to Caco2/HT29 MTX cells but not of GOS and glucose. Furthermore, 2′FL could significantly increase the colonization of A. muciniphila in the gut to alleviate colitis in mice. Overall, the interplay between A. muciniphila and 2′FL is expected to provide an advantageous ecological niche for A. muciniphila so as to confer further health benefits against colitis.

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“…Nevertheless, the therapeutic efficacy of A. muciniphila was not completely satisfactory depending on its colonization . Previous studies have shown that A.…”

Section: Discussionmentioning

confidence: 99%

“…muciniphila can significantly relieve acute colitis in mice. , Furthermore, the beneficial effect of A. muciniphila depends on the colonization rate. , Therefore, we investigated the effect of 2′FL and A. muciniphila alone or as synbiotics against colitis.…”

Section: Discussionmentioning

confidence: 99%

2′-Fucosyllactose Promotes Colonization of Akkermansia muciniphila and Prevents Colitis In Vitro and in Mice

Liu,

Zhang,

Zhang

et al. 2024

J. Agric. Food Chem.

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“…Akk, on top of ameliorating mucosal inflammation caused by DSS via the microbe–host interaction by enhancing gut barrier function, reduces the levels of inflammatory cytokines and elevates the diversity of the microbial community [ 97 ]. For instance, stable gastrointestinal tract colonization of Akk contributed to the therapy and prognosis of inflammatory intestinal diseases induced by DSS and intestinal radiation via changing the host gut microbial community structure, facilitating proliferation and reprogramming the gene expression profile of Lactobacillus murinus [ 103 ]. Similarly, cadmium usually induces intestinal damage, and treatment with Akk effectively ameliorates intestinal mucosal damage by producing melatonin [ 104 ].…”

Section: Akkermansia Muciniphila : An Anti-inflammatory and ...mentioning

confidence: 99%

Akkermansia muciniphila as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut–Liver–Brain Axes?

Jian

Liu

Wang

et al. 2023

IJMS

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Appreciation of the importance of Akkermansia muciniphila is growing, and it is becoming increasingly relevant to identify preventive and/or therapeutic solutions targeting gut–liver–brain axes for multiple diseases via Akkermansia muciniphila. In recent years, Akkermansia muciniphila and its components such as outer membrane proteins and extracellular vesicles have been known to ameliorate host metabolic health and intestinal homeostasis. However, the impacts of Akkermansia muciniphila on host health and disease are complex, as both potentially beneficial and adverse effects are mediated by Akkermansia muciniphila and its derivatives, and in some cases, these effects are dependent upon the host physiology microenvironment and the forms, genotypes, and strain sources of Akkermansia muciniphila. Therefore, this review aims to summarize the current knowledge of how Akkermansia muciniphila interacts with the host and influences host metabolic homeostasis and disease progression. Details of Akkermansia muciniphila will be discussed including its biological and genetic characteristics; biological functions including anti-obesity, anti-diabetes, anti-metabolic-syndrome, anti-inflammation, anti-aging, anti-neurodegenerative disease, and anti-cancer therapy functions; and strategies to elevate its abundance. Key events will be referred to in some specific disease states, and this knowledge should facilitate the identification of Akkermansia muciniphila-based probiotic therapy targeting multiple diseases via gut–liver–brain axes.

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“…Furthermore, two kinds of sulfate-degrading microorganisms have been described in the bacteria kingdom: (i) Sul dogenic, such as Desulfovibrio spp. or Bilophila spp, which use sulfate as a nal electron acceptor to generate energy and produce inorganic hydrogen sul de (HS) as an end-product that can be toxic when produced in large amounts and has been associated with IBD pathogenesis [18]; (ii) Sulfate assimilatory, including A. muciniphila, that consume energy to incorporate Sulfate in several organic compounds, including peptides and amino acids and may produce secondary metabolites which can be used as a carbon source for other commensal bacteria [19]. The A. muciniphila genome recovered from a metagenome sample (B238) from a mouse consuming Emmental revealed a complete Sulfur assimilatory pathway.…”

Section: Homeostasis Contextmentioning

confidence: 99%

“…murinus. This bacterium has shown promising probiotic properties in treating intestinal in ammation disorders; and a recent study has reported its ability to alleviate DSS-induced colitis in mice [19], [26]. Another crucial functional impact of Emmental-type cheese consumption in mice with DSS-induced colitis was the increased diversity of sugars and amino acids uptake systems (ABC transporters systems and phosphotransferases systems) found in Lg murinus MAG, suggesting an improved capacity to adapt and assimilate different kinds of nutrients.…”

Section: In Ammation Contextmentioning

confidence: 99%

Functional Swiss-type experimental cheeses diet promotes beneficial effects in mice gut microbiome during homeostasis and inflammation

Carvalho

Rabah

Carmo

et al. 2023

Preprint

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Background Nutritional interventions have been considered an alternative rationale for preventing Inflammatory Bowel Diseases. The investigation of their impact on the gut microbiota is a fundamental question since shifts in the composition of the commensal bacterial community are required for the onset and maintenance of colitis. Therefore, in this study, we investigated the effects of two types of cheeses, fermented by probiotic propionibacteria. One experimental single-strain cheese was solely fermented by Propionibacterium freudenreichii CIRM-BIA129. Another was an Emmental made in industrial conditions using the same propionic strain, in combination with Lactobacillus delbrueckii CNRZ327 and Streptococcus thermophilus LMD-9, as starters. Both kinds of cheese were tested in healthy conditions and the context of DSS-induced colitis in conventional C57BL6 mice and the gut microbiota was investigated. Results Based on the metagenomic analysis, our results suggest that cheese consumption, whatever the kind of cheese, did not disturb the typical microbial community, although the Emmental intake increased symbionts population as Romboutsia sp. and partially increased Akkermansia muciniphila. Furthermore, metabolic pathway reconstruction analysis suggests that A. muciniphila may produce acetate through sulfate assimilatory metabolism and may cooperate with other commensal species in tryptophan and glutamate metabolism to produce indole and gamma-aminobutyric acid. Considering the colitis context, the consumption of the Single-strain cheese restored some of the impaired microbiome metabolic functions, while Emmental cheese promoted the increase of Ligilactobacillus murinus. This bacterium presented several genes involved in producing metabolites and adhesin proteins with potential immunomodulatory activity. Conclusions This study concludes that the Emmental cheese effects increased the microbiota's capacity to produce metabolites involved in gut-brain axis regulation in intestinal homeostasis condition and, therefore, may represent a potential therapy for inflammatory neurodegenerative diseases. Regarding the colitis context, our results support the beneficial properties of functional Emmental cheese by suggesting possible anti-inflammatory mechanisms based on the promotion of Lg. murinus interaction with the host.

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Stable colonization of Akkermansia muciniphila educates host intestinal microecology and immunity to battle against inflammatory intestinal diseases

Cited by 24 publications

References 59 publications

2′-Fucosyllactose Promotes Colonization of Akkermansia muciniphila and Prevents Colitis In Vitro and in Mice

2′-Fucosyllactose Promotes Colonization of Akkermansia muciniphila and Prevents Colitis In Vitro and in Mice

Akkermansia muciniphila as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut–Liver–Brain Axes?

Functional Swiss-type experimental cheeses diet promotes beneficial effects in mice gut microbiome during homeostasis and inflammation

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