Stable graphene oxide–gold nanoparticle platforms for biosensing applications

Hernández-Sánchez, Dania; Villabona-Leal, Giovanny; Saucedo-Orozco, Izcoatl; Bracamonte, Victoria; Pérez, Elı́as; Bittencourt, Carla; Quintana, Mildred

doi:10.1039/c7cp04817c

Cited by 52 publications

(26 citation statements)

References 44 publications

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“…In particular, diabetes pathologies pushed the research to develop self-monitoring glucose and non-invasive glucose monitoring systems [5][6][7][8]. The electrochemical analytical method is attractive with respect to methods based on UV [9], plasmonic resonance [10], and surface enhanced Raman spectroscopies [11,12], on chromatography [13] and colorimetry [14], due to its easy fast monitoring, selectivity, sensitivity, simplicity of miniaturization and integration, stability, low-cost, and reliability [15]. Recently, the emergence of nanoscience and nanotechnology has led to great developments in electrochemical science and technology, which led to the new branch named electrochemical nanotechnology.…”

Section: Introductionmentioning

confidence: 99%

Dewetted Gold Nanostructures onto Exfoliated Graphene Paper as High Efficient Glucose Sensor

et al. 2019

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Non-enzymatic electrochemical glucose sensing was obtained by gold nanostructures on graphene paper, produced by laser or thermal dewetting of 1.6 and 8 nm-thick Au layers, respectively. Nanosecond laser annealing produces spherical nanoparticles (AuNPs) through the molten-phase dewetting of the gold layer and simultaneous exfoliation of the graphene paper. The resulting composite electrodes were characterized by X-ray photoelectron spectroscopy, cyclic voltammetry, scanning electron microscopy, micro Raman spectroscopy and Rutherford back-scattering spectrometry. Laser dewetted electrode presents graphene nanoplatelets covered by spherical AuNPs. The sizes of AuNPs are in the range of 10–150 nm. A chemical shift in the XPS Au4f core-level of 0.25–0.3 eV suggests the occurrence of AuNPs oxidation, which are characterized by high stability under the electrochemical test. Thermal dewetting leads to electrodes characterized by faceted not oxidized gold structures. Glucose was detected in alkali media at potential of 0.15–0.17 V vs. saturated calomel electrode (SCE), in the concentration range of 2.5μM−30 mM, exploiting the peak corresponding to the oxidation of two electrons. Sensitivity of 1240 µA mM−1 cm−2, detection limit of 2.5 μM and quantifications limit of 20 μM were obtained with 8 nm gold equivalent thickness. The analytical performances are very promising and comparable to the actual state of art concerning gold based electrodes.

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Section: Introductionmentioning

confidence: 99%

Dewetted Gold Nanostructures onto Exfoliated Graphene Paper as High Efficient Glucose Sensor

et al. 2019

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“…The remarkable facet of SERS technique is its high specificity, providing unique “fingerprints” of molecules under study at trace concentrations. The technique can now detect vibrational signatures of molecules down to single molecule detection regime, arguably the ultimate sensitivity in terms of analytical applications …”

Section: Introductionmentioning

confidence: 99%

Infused self‐assembly on Langmuir–Blodgett Film: Fabrication of highly efficient SERS active substrates with controlled plasmonic aggregates

Saha

Ghosh

Chowdhury

2018

J Raman Spectroscopy

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A facile procedure towards the fabrication of highly reproducible, large area surface-enhanced Raman scattering (SERS) active substrates through integration of Langmuir-Blodgett and self-assembly technique has been reported. The plasmonic architectures of the substrates can be tuned at will to control the hot spots and hence the overall enhancements of SERS signal. The asprepared substrates of classes "A" and "B" incubated in gold nanocolloids show their respective efficacies as efficient SERS sensing scaffolds for detecting 4-MPy molecule at ultrasensitive concentrations. Moreover, these substrates are unique in their kinds, where explicit or concomitant presence of protonated and deprotonated forms of 4-MPy can be detected at trace concentrations. The substrates also exhibit remarkable spectral reproducibility and show early promise to overcome the "SERS uncertainty principle". To our knowledge, this genre of SERS active substrates with facile control over plasmonics, is the first report of its kind and are expected to provide new direction towards successful fabrication of the next generation SERS sensing platforms.

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“…The products were washed by centrifugation to remove all the by-products of the reaction. The average size distribution is 36 ± 9 nm [15]. …”

Section: Methodsmentioning

confidence: 99%

Imaging carbon nanostructures’ reactivity: a complementary strategy to define chemical structure

et al. 2018

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In the search for the integration of carbon nanostructures in composite and functional materials, covalent organic reactions are successfully performed. This approach resulted in the construction of tailored chemical interfaces facilitating incorporation of nanocarbons. By a combination of different characterization techniques, such as high-resolution X-ray photo-spectroscopy, thermogravimetric analysis, Raman spectroscopy, UV-vis-nIR, and fluorescence spectroscopies, it is possible to identify and quantify the functional moieties covalently attached to the carbon frame. However, the determination of the structural conformation of functionalized nanostructures remains a difficult task. In this work, we present a straightforward methodology to visualize by transmission electron microscopy the functional moieties covalently attached to the carbon network in carbon nanotubes and graphene. The identification of the functionalities occurs in colloidal dispersions by using gold nanoparticles (AuNPs) as discriminating markers by molecular recognition or by the direct growth of AuNPs on the oxygenated moieties. This methodology, in combination with other characterization analysis, is expected to improve the design of hierarchical interfaces by the spatial localization of the functionalities responsible for colloidal stabilization in solvents with different polarities, different from their homogeneous incorporation into different matrices.

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Stable graphene oxide–gold nanoparticle platforms for biosensing applications

Cited by 52 publications

References 44 publications

Dewetted Gold Nanostructures onto Exfoliated Graphene Paper as High Efficient Glucose Sensor

Dewetted Gold Nanostructures onto Exfoliated Graphene Paper as High Efficient Glucose Sensor

Infused self‐assembly on Langmuir–Blodgett Film: Fabrication of highly efficient SERS active substrates with controlled plasmonic aggregates

Imaging carbon nanostructures’ reactivity: a complementary strategy to define chemical structure

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