Stable Hydrophilic Polydimethylsiloxane Surfaces Produced by Plasma Treatment for Enhanced Cell Adhesion

Jensen, Carina; Gurevich, Leonid; Patriciu, A.; Struijk, Johannes; Zachar, Vladimír; Pennisi, Cristian Pablo

doi:10.1007/978-3-642-21683-1_26

Cited by 8 publications

(12 citation statements)

References 9 publications

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“…The surface treatment of PDMS and silicone rubbers with plasmas has been revealed as a fast and effective method for improving their adhesion, and for imparting surface polarity and biocompatibility . Most of the existing studies in the literature on the surface modification of PDMS with plasmas have been carried out by using low pressure plasma, corona discharge, and dielectric barrier discharge treatments.…”

Section: Introductionmentioning

confidence: 99%

Surface Treatment of Polydimethylsiloxane (PDMS) with Atmospheric Pressure Rotating Plasma Jet. Modeling and Optimization of the Surface Treatment Conditions

Jofre-Reche

Pulpytel

Fakhouri

et al. 2015

Plasma Processes & Polymers

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Surface treatment of polydimethylsiloxane (PDMS) with a rotative nozzle atmospheric pressure plasma jet (APPJ) was reported. Operating conditions were optimized by statistical design of experiments, using water contact angle and XPS as response variables; OES (optical emission spectroscopy) was used for plasma diagnosis. The nozzle‐PDMS distance and the torch speed were the most influencing parameters and were optimum at 6.6 mm and 10.3 m s−1, respectively. The extent of hydrophobic recovery of treated PDMS, investigated by water contact angle measurements, was less than what reported in the literature for this amorphous polymer. However, the APPJ treatment proposed in this paper is meant to be inserted in line for a homogeneous surface treatment of PDMS for enhanced adhesion improvement to coatings or adhesives.

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Section: Introductionmentioning

confidence: 99%

Surface Treatment of Polydimethylsiloxane (PDMS) with Atmospheric Pressure Rotating Plasma Jet. Modeling and Optimization of the Surface Treatment Conditions

Jofre-Reche

Pulpytel

Fakhouri

et al. 2015

Plasma Processes & Polymers

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“…Most of the methods introduced hydrophilic surfaces on silicone. Oxidation through oxygen plasma or water vapor plasma treatment was shown to produce hydroxyl groups (AOH) on the PDMS surface temporarily [28] or semi-permanently [29]. A solvent vaporization method [30] and simple dipping or swelling of PDMS platforms in polymeric solutions [31,32] have also been used for non-covalent modifications.…”

Section: Discussionmentioning

confidence: 99%

Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings

et al. 2014

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“…[15][16][17]32 In this work, the aim was to determine the in vivo local responses to PDMS implants treated by a water vapor plasma method that has previously shown to enhance cell adhesion in vitro. 24,33 We chose a rodent model of subcutaneous implantation, as it represents the standard model to test for local effects after implantation of polymeric substrates. Although a sham operation site was initially included to assess the effect of the surgery on the early tissue responses, the sham wound was completely healed at the time of retrieval of the first implant (2 weeks).…”

Section: Discussionmentioning

confidence: 99%

“…Plasma-based surface modification techniques represent an attractive approach for surface functionalization of PDMS and have recently gained particular interest due to their flexibility, reproducibility, and relatively low cost. [19][20][21][22][23][24] The standard means to increase the hydrophilicity of PDMS involve treatment with oxygen plasma, however, the usability of this technique is limited to in vitro applications as the surface hydrophobicity is eventually re-established. 25,26 Recently, we have reported a novel plasma treatment approach based on water vapor that provides long-term stable hydrophilic PDMS surfaces with excellent cell compatibility.…”

Section: Introductionmentioning

confidence: 99%

“…25,26 Recently, we have reported a novel plasma treatment approach based on water vapor that provides long-term stable hydrophilic PDMS surfaces with excellent cell compatibility. 24 The substantial stability displayed by the surfaces would enable the use of the method to in vivo applications. In particular, we hypothesize that water vapor plasma could be used to promote connective tissue attachment to PDMS implants to mitigate the issues resulting from long-term implantation.…”

Section: Introductionmentioning

confidence: 99%

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Increased connective tissue attachment to silicone implants by a water vapor plasma treatment

Jensen

Gurevich

Patriciu³

et al. 2012

J Biomedical Materials Res

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Polydimethylsiloxane (PDMS) is the most common type of silicone polymer for the fabrication of implantable medical devices. Because of its inherent hydrophobic nature, the PDMS surface does not readily promote cellular adhesion, which leads to diverse clinical issues. Previously, we reported a simple water vapor plasma treatment of PDMS surfaces that resulted in stable long-term wettability and excellent in vitro cell compatibility. In this work, we report investigation of the in vivo local responses to PDMS implants treated by water vapor plasma using a subcutaneous rat model. The local tissue responses were assessed after 2 and 4 weeks of implantation by means of macroscopic and histomorphometric analysis. After 2 weeks of implantation, the plasma-treated implants elicited the formation of fibrous tissue capsules that were significantly thinner, more adherent, and vascularized than the control counterparts. The improved cell adhesion was correlated with an increased amount of cells attached to the implant surface after retrieval. There was no difference in the inflammatory response between untreated and treated samples. This study provides a rational approach to optimize the long-term performance of silicone implants, which is likely to have a significant impact in clinical applications demanding enhanced tissue integration of the implants.

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Stable Hydrophilic Polydimethylsiloxane Surfaces Produced by Plasma Treatment for Enhanced Cell Adhesion

Cited by 8 publications

References 9 publications

Surface Treatment of Polydimethylsiloxane (PDMS) with Atmospheric Pressure Rotating Plasma Jet. Modeling and Optimization of the Surface Treatment Conditions

Surface Treatment of Polydimethylsiloxane (PDMS) with Atmospheric Pressure Rotating Plasma Jet. Modeling and Optimization of the Surface Treatment Conditions

Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings

Increased connective tissue attachment to silicone implants by a water vapor plasma treatment

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