Stable isotopes of lithium

Stokes, Peter E.; Okamoto, Michiko; Lieberman, K.W.; Alexander, George J.; Triana, E.

doi:10.1097/00004714-198212000-00026

Cited by 3 publications

(1 citation statement)

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“…Figure 1 highlights that the range displayed by biologic materials is in fact similar as that estimated for the global Earth (∼50‰). Another line of evidence of the biological control on Li isotopes comes from studies focusing on the relative distributions and biological effects of pure 6 Li and 7 Li related to a therapeutic use, 9 , 10 , 11 suggesting a higher diffusivity of 6 Li than 7 Li. Also, the results contained in Figure 1 indicate that Li isotopes accumulate differently in organs and tissues where they can exert distinctive biological effects.…”

Section: Introductionmentioning

confidence: 99%

Biological fractionation of lithium isotopes by cellular Na+/H+ exchangers unravels fundamental transport mechanisms

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Biological fractionation of lithium isotopes by cellular Na+/H+ exchangers unravels fundamental transport mechanisms

et al. 2023

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Lithium toxicology: Effect of isotopic composition on lethality and behavior

Alexander¹,

Lieberman

Okamoto

et al. 1982

Pharmacology Biochemistry and Behavior

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Variations in Lead Isotopic Abundances in Sprague-Dawley Rat Tissues: Possible Reason of Formation

Liu

Ouyang

et al. 2014

PLoS ONE

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It has been reported in previous research that the lead isotopic composition of blood, urine and feces samples statistically differed from the given lead sources in Sprague-Dawley (SD) rats. However, the reason for this phenomenon is still unclear. An animal experiment was performed to investigate the lead isotope fractionation in diverse biological samples (i.e., lungs, liver, kidneys, bone) and to explore the possible reasons. SD rats were intratracheally instilled with lead acetate at the concentrations of 0, 0.02, 0.2, and 2 mg/kg body weight. Biological samples were collected for lead isotope analysis using an inductively coupled plasma mass spectrometry (ICP-MS). Significant differences are observed in lead isotope abundances among the diverse biological samples. The lead isotope abundances (206Pb, 207Pb and 208Pb) in diverse biological samples show different degrees and directions of departure from the given lead source. The results suggest that differences in enrichment or depletion capacity for each lead isotope in the various tissues might lead to the variation in lead isotopic abundances in tissues. Moreover, a nonlinear relationship between the blood lead level and the lead isotope abundances in liver and bone is observed. When the whole-blood level is higher than 50 ng/mL, the lead isotopic compositions of biological samples tend to be the same. Thus, the data support the speculation of a fractionation functional threshold.

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Stable isotopes of lithium

Cited by 3 publications

References 0 publications

Biological fractionation of lithium isotopes by cellular Na+/H+ exchangers unravels fundamental transport mechanisms

Biological fractionation of lithium isotopes by cellular Na+/H+ exchangers unravels fundamental transport mechanisms

Lithium toxicology: Effect of isotopic composition on lethality and behavior

Variations in Lead Isotopic Abundances in Sprague-Dawley Rat Tissues: Possible Reason of Formation

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