Stable vesicle assemblies on surfaces of hydrogel nanoparticles formed from a polysaccharide modified with lipid moieties

Review on the advancements of magnetic gels: towards multifunctional magnetic liposome-hydrogel composites for biomedical applications

“…This hydrogel showed shear-thinning properties, which allow it to be used as injectable biomaterial, and promotes a slow and sustained release of drug over more than one week. Another interesting type of liposomal hydrogel assembly was presented by Kang et al [262]. They prepared a hydrogel nanoparticle composed of hyaluronic acid modified with 1,2dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) and methacrylic anhydride (MA), through an inverse microemulsion upon UV radiation, and with the purpose of creating a phospholipid assembly on the surface of the nanogel core, using lipid bilayers bearing amphiphiles (Figure 9).…”

“…Also, it was concluded that the mechanism of drug release is performed by two steps: (1) slow diffusion of the liposomes and disruption of their lipid membrane releasing the drug and (2) diffusion of free drug towards the hydrogel matrix. Reprinted from [262] with permission from Elsevier, 2020.…”

“…(B) Cryogenic TEM image of the formed multilamellar vesicles composed of DMPC bearing DSSN+ on the surface of the nanogel core. Abbreviations: DMPE (1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine); DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine); DSSN+ (4,4'-bis[4'-(N,N-bis(6''-(N,N,N-trimethylammonium)hexyl)amino)styryl] stilbene tetraiodide).Reprinted from[262] with permission from Elsevier, 2020.…”

Fabrication and Characterization of Stable Soy β-Conglycinin–Dextran Core–Shell Nanogels Prepared via a Self-Assembly Approach at the Isoelectric Point

“…Li and co-authors reported that lysozyme–dextran core–shell nanogels with a hydrodynamic diameter around 200 nm could be produced by two steps: Maillard reaction and heat gelation process . However, there is an increasing need to minimize the size of colloidal particles to nanoscale (0–100 nm), for the reason that smaller-size nanogels are able to deliver functional materials with longer circulation time in vivo; that is to say, the effects of controlled release and cellular uptake were improved. , …”

“…14 However, there is an increasing need to minimize the size of colloidal particles to nanoscale (0−100 nm), for the reason that smaller-size nanogels are able to deliver functional materials with longer circulation time in vivo; that is to say, the effects of controlled release and cellular uptake were improved. 15,16 Furthermore, little research has been made on constructing plant protein based nanogels through the Maillard reaction and self-assembly. The low-cost soy protein is extensively used in the food industry due to its functional properties, which are more valuable in many instances compared with those of animal proteins.…”