2002
DOI: 10.7164/antibiotics.55.155
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Stachyflin and Acetylstachyflin, Novel Anti-influenza A Virus Substances, Produced by Stachybotrys sp. RF-7260. I. Isolation, Structure Elucidation and Biological Activities.

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Cited by 82 publications
(43 citation statements)
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“…Feeding DL-lysine to a culture of Stachybotrys sp. RF-7260 induced the formation of the novel compounds, SQ-02-S-L2 and -L1, and feeding DLvaline the formation of SQ-02-S-VI and -V2 (Minagawa et al 2002a). In addition, acetylstachyflin, novel antiinfluenza A virus substances were also produced by Stachybotrys sp.…”
Section: Stachybotrys In Biocontrol During Mycoparasitism Of Hyphae Amentioning
confidence: 97%
“…Feeding DL-lysine to a culture of Stachybotrys sp. RF-7260 induced the formation of the novel compounds, SQ-02-S-L2 and -L1, and feeding DLvaline the formation of SQ-02-S-VI and -V2 (Minagawa et al 2002a). In addition, acetylstachyflin, novel antiinfluenza A virus substances were also produced by Stachybotrys sp.…”
Section: Stachybotrys In Biocontrol During Mycoparasitism Of Hyphae Amentioning
confidence: 97%
“…Therefore, stachyflin may be used as a tool for probing the molecular mechanism of HA conformational change at low pH, and as a pharmaceutical agent for the treatment of influenza. Further, stachyflin and its derivatives have been deeply discussed, including improvement of oral and intranasal absorption [73,74], isolation, synthesis, structure elucidation, biological activities, and preliminary structure activity relationships [75][76][77]. (Need one more sentence) It is interesting that diverse compounds have similar biological activities against the HA-mediated membrane fusion of influenza virus.…”
Section: Inhibitors Of Membrane Fusion-inducing Conformational Changementioning
confidence: 99%
“…The mechanism of stachyflin action was shown to interfere with the low-pH induced conformational change of HA [42]. The same research group continued their effort in the development of stachyflin (I) derivatives (acetylstachyflin, II, III, and their phosphate esters, I-Phos, II-Phos and III-Phos) and found that intranasally administered III-Phos has anti-influenza-virus activity in animal studies [43][44][45][46]. Oral absorption properties were evaluated for stachyflin (I) and its derivatives (II, and their phosphate esters, I-Phos and II-Phos) with or without employing vehicles [43].…”
Section: Drug Discovery Based On Hamentioning
confidence: 99%