Stacked aryl groups inP-resolved cyclic phosphonamides as a new conformational constraint

Abstract

π–π stacking as a conformational constraint in the P-resolved cyclic phosphonamides.

A combined structural and computational investigation of aminobenzylnaphthol compounds derived from the Betti reaction using valine methyl ester

“…As a whole, the (S, S)-aminobenzylnaphthols 5-7 show a similar shape (Figure S20, ESI), at variance with the hydrogen, fluorine and chlorine atoms, as already reported for the crystal structures of aminobenzylnaphthols 6 and of some cyclic phosphonamides deriving from them. 22 However, our analysis, that will be shown in the ongoing of this paper, shows unequivocally that the five crystal structures are built up by different weak interactions. Different crystal packings as a consequence of the simple halogen atom variation were reported, and a very recent example in the case of haloaryl moieties is representative.…”

Antiproliferative Activity of Aminobenzylnaphthols Deriving from the Betti Reaction

“…This process is a multi-component reaction between 2-naphthol, aryl aldehydes, and amines that yields the cited aminobenzylnaphthols. Since its discovery in the early 20th century, the Betti reaction was seldom applied until its rediscovery due to our research, starting in 1998 [10] and continuing over the following years [9][10][11][12][13][14][15][16][17][18]. Since 1999, many researchers around the world have applied the Betti reactrion [9].…”