Staff-to-patient transmission of meticillin-resistant Staphylococcus aureus: do bacterial factors play a role?

Haill, Claire F.; Allwood, Alex; Kearns, Angela; Jenks, Peter J.

doi:10.1016/j.jhin.2011.06.011

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…This could be explained by the fact that many nosocomial infections associated with MRSA are caused by infection of the patient by multiresistant hospital strains from other patients or health care personnel [23,24,25] and are frequently associated with prolonged hospitalization. In addition, the intense exposure to antibiotics to which these patients are subjected also plays an important role in infection due to multiresistant microorganisms during their stay in hospital [26,27,28] as well as recurrence of certain infections [29,30,31].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Methicillin-Resistant Staphylococcus aureus: Effect of Different Criteria for Elimination of Duplicates

Álvarez-Paredes

López-Riquelme²,

Rodrı́guez³

et al. 2013

Chemotherapy

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Background: The purpose of this study is to compare the effect of different systems for eliminating duplicates in order to optimize the calculation of the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infection. Methods: We compare the Clinical and Laboratory Standards Institute (CLSI) criterion, time criteria and the criterion recommended by the European Antimicrobial Surveillance System (EARSS). Results: Multiple isolates of MRSA are frequently recovered from successive cultures from the same patient (the average isolation rate of MRSA is 2.72), which demonstrates the importance of eliminating duplicates. When CLSI criterion data are compared to those obtained using other criteria, a significant increase in the number of S. aureus isolates was found applying time criteria (up to 36%) or the EARSS criterion (13%). There is also an increase in the methicillin resistance rate (between 3.31 and 3.96%; p < 0.01). Conclusions: We believe that the EARSS method, with the proper quality controls and latest software tools available, is the best for determining the true situation of MRSA.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Methicillin-Resistant Staphylococcus aureus: Effect of Different Criteria for Elimination of Duplicates

Álvarez-Paredes

López-Riquelme²,

Rodrı́guez³

et al. 2013

Chemotherapy

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“…Nosocomial infections are often associated with S. aureus , commonly transmitted either by direct contact with colonized healthcare workers or as a result of invasive medical procedures including surgeries and the introduction of medical implants. [3–5] Treating vulnerable patient populations and the ability of the bacterium to acquire multiple drug resistance further complicates effective treatment of nosocomial infections. In addition to MRSA, glycopeptide intermediate S. aureus and vancomycin-resistant S. aureus (VRSA) have emerged.…”

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confidence: 99%

Prevention and treatment ofStaphylococcus aureusbiofilms

Bhattacharya

Wozniak

Stoodley

et al. 2015

Expert Review of Anti-infective Therapy

217

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S. aureus colonizes both artificial and tissue surfaces in humans causing chronic persistent infections that are difficult to cure. It is a notorious pathogen due to its antibiotic recalcitrance and phenotypic adaptability, both of which are facilitated by its ability to develop biofilms. S. aureus biofilms challenge conventional anti-infective approaches, most notably antibiotic therapy. Therefore there is an unmet need to develop and include parallel approaches that target S. aureus biofilm infections. This review discusses two broad anti-infective strategies: (1) preventative approaches (anti-biofilm surface coatings, the inclusion of biofilm-specific vaccine antigens); and (2) approaches aimed at eradicating established S. aureus biofilms, particularly those associated with implant infections. Advances in understanding the distinct nature of S. aureus biofilm development and pathogenesis have led to growing optimism in S. aureus biofilm targeted anti-infective strategies. Further research is needed however, to see the successful administration and validation of these approaches to the diverse types of infections caused by S. aureus biofilms from multiple clinical strains.

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Prolonged outbreak of meticillin-resistant Staphylococcus aureus in a cardiac surgery unit linked to a single colonized healthcare worker

Haill

Fletcher

Archer

et al. 2013

Journal of Hospital Infection

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Staff-to-patient transmission of meticillin-resistant Staphylococcus aureus: do bacterial factors play a role?

Cited by 4 publications

References 4 publications

Prevalence of Methicillin-Resistant <b><i>Staphylococcus aureus</i></b>: Effect of Different Criteria for Elimination of Duplicates

Prevalence of Methicillin-Resistant <b><i>Staphylococcus aureus</i></b>: Effect of Different Criteria for Elimination of Duplicates

Prevention and treatment ofStaphylococcus aureusbiofilms

Prolonged outbreak of meticillin-resistant Staphylococcus aureus in a cardiac surgery unit linked to a single colonized healthcare worker

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