Stage 3: The Ulcerated Foot

Edmonds, Michael; Foster, Alethea Vm; Sanders, Lee J.

doi:10.1002/9780470696316.ch4

A Practical Manual of Diabetic Foot Care 2008

DOI: 10.1002/9780470696316.ch4

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Stage 3: The Ulcerated Foot

Michael Edmonds

Alethea Vm Foster

Lee J. Sanders

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2008

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Becaplermin gel in the treatment of diabetic neuropathic foot ulcers

Παπάνας

Maltezos²

2008

CIA

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Diabetic foot ulcers remain a major cause of morbidity. Signifi cant progress has been accomplished in ulcer healing by improved management of both ischemia and neuropathy in the diabetic foot. Nevertheless, there is a vital need for further improvement. Becaplermin gel represents an important therapeutic advance for diabetic neuropathic foot ulcers with adequate blood supply. Randomized controlled trials have shown that it is effective in increasing healing rates. However, this effi cacy has not translated to positive clinical experience, and the drug is not widely used. Moreover, becaplermin is an expensive medication. Even though it has repeatedly been estimated as cost-effective, its high cost may be prohibitive for some clinicians, especially in developing countries. Clearly, further work is needed to clarify whether use of becaplermin is justifi ed in everyday clinical practice. Future research also needs to assess the potential room for improvement with becaplermin, for instance by combination with other growth factors or by exploring alternative modes of drug delivery.

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Becaplermin gel in the treatment of diabetic neuropathic foot ulcers

Παπάνας

Maltezos²

2008

CIA

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Stage 3: The Ulcerated Foot

Cited by 1 publication

References 93 publications

Becaplermin gel in the treatment of diabetic neuropathic foot ulcers

Becaplermin gel in the treatment of diabetic neuropathic foot ulcers

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