The geochemical features of the ores present in the oxidation zone of the gold-copper Malmyzh mineral deposit are characterized. This deposit is located in the the Nanaian region of the Khabarovsk Territory in the Russian Federation, and a technological assessment of ores present was carried out. The initial gold content in the oxidized ore is 0.1–1.2 ppm, and the leachability of gold from different size fractions by hot cyanide revealed the fact that the ore is not refractory and characterized by increased cyanide consumption. The results demonstrated a high gold content in fine size fractions. Different leaching reagents were applied for oxidized ore testing. These reagents were used both for oxidative pretreatment and leaching process. Activation of solutions was carried out by electrolysis and UV radiation. Different reagent combinations were tested in laboratory with the highest gold recovery (94%) provided by the chloride system with peroxide-sulfuric pretreatment of the oxidized ore. The same reagent combination resulted in 91–94% gold recovery during the column leaching of crushed (−10 mm) ore.