Stage II carcinoma of the endometrium

Surwit, Earl A.; Fowler, Wesley C.; Rogoff, Edward E.; Jelovsek, Frederick R.; Parker, Roy T.; Creasman, William T.

doi:10.1016/0360-3016(79)91210-0

Cited by 50 publications

(15 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the preoperative evaluation of cervical invasion by endometrial carcinoma is very important for selecting the appropriate surgical procedure and for assessing the patient's prognosis. According to previous reports concerning the prognosis and surgical treatment of patients with endometrial carcinoma, the prognosis and treatment in patients with cervical invasion are quite different from those in patients without cervical invasion [17][18][19][20][21][22][23][24]. When there is cervical invasion, the prognosis is poorer [20,21] and patients undergo more extensive surgical alone.…”

Section: Discussionmentioning

confidence: 94%

“…According to previous reports concerning the prognosis and surgical treatment of patients with endometrial carcinoma, the prognosis and treatment in patients with cervical invasion are quite different from those in patients without cervical invasion [17][18][19][20][21][22][23][24]. When there is cervical invasion, the prognosis is poorer [20,21] and patients undergo more extensive surgical alone. Because there have been no reports in which cervical invasion was estimated in terms of whether the tumor invaded to the cervical epithelium or to the cervical stroma, we evaluated not only the presence of cervical invasion by endometrial carcinoma but also the extent of cervical invasion in detail: endocervical glandular involvement only or cervical stromal invasion.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Endometrial carcinoma: efficacy of thin-section oblique axial MR images for evaluating cervical invasion

et al. 1999

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 94%

Endometrial carcinoma: efficacy of thin-section oblique axial MR images for evaluating cervical invasion

et al. 1999

View full text Add to dashboard Cite

show abstract

“…Reisinger and Boothby found that grade was the most important predictor of survival, and infiltration of the myometrium was less significant (6,7,9,13,15) . Our results showed, in a univariate analysis, a significant relationship between stage and survival and stage with grade and survival (Figs 1 and 2).…”

Section: Discussionmentioning

confidence: 99%

“…The 5-year survival of stage II, clinically or pathologically staged, ranges from 45 to 90% (5)(6)(7)(11)(12)(13)(14)(15)(16)(17) . Our analysis of 42 pathologic stage II patients showed a 5-year disease specific survival of 84.5%.…”

Section: Discussionmentioning

confidence: 99%

Treatment results in women with clinical stage I and pathologic stage II endometrial carcinoma

Jobsen,

Schutter,

Meerwaldt

et al. 2001

Int J Gynecol Cancer

View full text Add to dashboard Cite

The aim of this study is to report survival and results of therapy and possible prognostic factors in women with pathologic stage II endometrial carcinoma. Forty-two patients with pathologic stage II endometrial carcinoma were treated at the department of Radiation Oncology of the Medisch Spectrum Twente between 1987 and 1998. All patients received external radiotherapy following standard surgical procedures and no adjuvant systemic therapy was given. From the 42 patients 21 had a pathologic stage IIA and 21 stage IIB. The median follow-up was 62 months. The overall recurrence rate was 21.5% (9/42). Seven patients had distant metastasis, of which three also had locoregional recurrence, vaginal vault and/or pelvic. The presence of myometrial invasion (> ½) and/or lymph-angioinvasion showed a significant relation with distant metastasis (P= 0.017). Stage IIB showed more recurrences, 33% (7/21). There was a significant different 5-year disease specific survival for stage IIA and IIB, respectively, 95% and 74% (P= 0.0311). Patients with a differentiation grade 3 and stage IIB showed a significantly poorer (P= 0.003) 5-year survival of 48.6% (P= 0.003). Results obtained in the present series of patients are in accordance with the literature. The present treatment policy seems justified, except for patients with pathologic stage IIB and grade 3, in which a more aggressive treatment should be considered.

show abstract

“…Fortunately, 75-80% of patients present with early disease (FIGO stage I), and resultant cure rates of 80-90% have been reported (1)(2)(3). Stage II endometrial cancer accounts for about 8-20% (4) of all cases, and survival rates for this stage vary widely in the literature (4)(5)(6)(7)(8)(9)(10).…”

mentioning

confidence: 99%

Stage II adenocarcinoma of the endometrium treated by two standard regimens of combined preoperative irradiation and surgery

Zablow¹,

Adams²,

Gregori

et al. 1994

Int J Gynecol Cancer

View full text Add to dashboard Cite

We retrospectively analyzed 77 patients with stage II endometrial carcinoma treated with standard regimens of preoperative radiotherapy (RT) and surgery (S). The age range was 31-74 years with a median of 56.3 years. Thirty-three patients received 40 Gy whole pelvis RT followed by either radical or modified radical hysterectomy. Forty-four patients received 50 Gy whole pelvis RT and sequential intrauterine and intravaginal cesium-137 brachytherapy followed by a simple hysterectomy. Median follow-up was 111 months. No patient was lost to follow-up. The overall 5-year actuarial survival was 78%. There was no significant difference between the two treatment groups. Several prognostic variables were analyzed. Those with histologic grade I and II had 5-year survival of 89% and 83%, respectively, compared to 62% for grade III (P =0.045). The 5-year survival for microscopic cervical involvement was 87% compared to 59% for gross involvement (P= 0.008). Patients with negative or microscopic residual tumor in the surgical specimen and those with negative lymph nodes had less risk of treatment failure. Local failure occurred in only 9%. Major complications (3%) were seen only in the radical surgery group. Combined preoperative RT and S provide high cure rates with minimal complications for patients with stage II endometrial carcinoma. Patients with adverse prognostic factors are candidates for trials of more aggressive local and systemic therapy.

show abstract

Stage II carcinoma of the endometrium

Cited by 50 publications

References 3 publications

Endometrial carcinoma: efficacy of thin-section oblique axial MR images for evaluating cervical invasion

Endometrial carcinoma: efficacy of thin-section oblique axial MR images for evaluating cervical invasion

Treatment results in women with clinical stage I and pathologic stage II endometrial carcinoma

Stage II adenocarcinoma of the endometrium treated by two standard regimens of combined preoperative irradiation and surgery

Contact Info

Product

Resources

About