Stage III and Metastatic Lymph Node Ratio Are the only Independent Prognostic Factors in Colorectal Signet-ring Cell Carcinoma Patients

Annicchiarico, Alfredo; Morini, Andrea; Romboli, Andrea; Riccò, Matteo; Leonardi, Francesco; Crafa, Pellegrino; Virgilio, Edoardo; Dell'Abate, P; Costi, Roberta

doi:10.21873/anticanres.14742

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…Having suffered the prolonged, severe and imbalanced caloric restriction lacking in fruit, vegetables, fiber, calcium, folic acid and vitamin D could undoubtedly take part to this type of enteral carcinogenesis (26). Moreover, differently from non-Jewish population, Ashkenazi Jews (who constitute around 75% of world Jewry today, 92% before WWII) could be affected with a hereditary form of CRC characterized by mutations of tumor suppressor genes coding for Breast Related Cancer Antigens 1 or 2 (BRCA1 and BRCA2): such a genetic predisposition could differ from the mechanisms commonly involved in the inherited or sporadic forms of CRC affecting the rest of the general population and also take part in the higher CRC rates observed in HS through the reviewed studies (37)(38)(39)(40)(41).…”

Section: Resultsmentioning

confidence: 99%

The Holocaust Is a Significant and Independent Risk Factor of Late-Onset Cancers: A Systematic Review of the Literature and Original Data on Jewish Israeli, Jewish Non-Israeli and Non-Jewish Non-Israeli Survivors

Virgilio

Camilli²,

Gili³

et al. 2021

Anticancer Res

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Background/Aim: Seventy-six years after Auschwitz Liberation, the Holocaust keeps on persecuting its surviving victims. As witnessed by the psychiatric and medical literature in the last decades, in fact, the Holocaust survivors (HS) appear to suffer from several Shoah-related late-onset diseases impacting their survival, such as internal illnesses and posttraumatic stress disorder (PTSD). Cancer represents a further severe pathology which seems to be connected with the Holocaust experience. Our aim was to review the existing knowledge of Holocaust-related cancer in HS in order to assess its real incidence and clinicoprognostic significance. Materials and Methods: We systematically reviewed the literature dealing with Israeli Jewish and non-Jewish non-Israeli HS developing cancer. We also reviewed and analyzed the cancer data of noted Jewish HS not resident or having resided in Israel available as public information. Results: We found 16 and 15 studies on Israeli Jews and non-Jewish non-Israeli survivors, respectively.A statistically significant association between the Holocaust and development of late-onset cancer in HS was seen in most studies with cancer adversely impacting the survival. We also selected 330 noted Jewish non-Israeli HS: genocide-related late-onset cancer resulted to be a significant and independent risk factor of poor prognosis (p<0.0001) imparting shorter survival in affected versus non-cancer subjects (57 versus 64 years, respectively, p=0.0001). Conclusion: Although 76 years have passed, our review shows how the Holocaust keeps on burdening its survivors. Moreover, we offered the first analysis of Jewish HS not resident or having resided in Israel in terms of genocide-related late-onset diseases focusing on cancer. Further studies on Jewish non-Israeli HS are needed in order to corroborate our findings on late-onset cancer occurring in this targeted population.The Holocaust undoubtedly represents one of the darkest pages in the history of mankind: still today, European concentration and extermination camps, the ghettos and all the Memorial sites are steeped in horrors and crimes perpetrated by the Nazi Germany (1). Interestingly, differently from other past or current genocides, only the Shoah was characterized by a systematic and dehumanized medicalization of the sufferings (1, 2). To the physicians and medical students of today, in fact, it is emotionally and rationally shocking to know that the atrocities inflicted in anus mundi were realized with the active complicity of the German medical community and that, with very few notable exceptions, history has ignored 2745 This article is freely accessible online.

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Section: Resultsmentioning

confidence: 99%

The Holocaust Is a Significant and Independent Risk Factor of Late-Onset Cancers: A Systematic Review of the Literature and Original Data on Jewish Israeli, Jewish Non-Israeli and Non-Jewish Non-Israeli Survivors

Virgilio

Camilli²,

Gili³

et al. 2021

Anticancer Res

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“…Even at this stage, the patient benefited from chemotherapy, especially because the surgical procedure was successful, as mentioned in several studies [13,14], but, of course, the signet-ring cell carcinoma histology per se signifies a dismal evolution [15,16].…”

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confidence: 96%

Collision Tumors of the Colon and Peritoneum: Signet-Ring Cell Carcinoma and Granular Cell Tumor

Lazureanu,

Anderco,

Dema

et al. 2023

Life

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Collision tumors, although rare, characterized by two distinctive (morphological, as well immunohistochemical) and spatially independent tumor components at the same location, are always puzzling for clinicians, pathologists, and patients because they do not fit into the usual approaches, being neither diagnostic nor therapeutic. Reviewing the specialized literature, to date, collision tumors have been reported in multiple locations such as the skin, esophagus, stomach, intestine, liver, kidney, bladder, adrenal gland, or thyroid. We report a case of coexistence at the same site of a malignant tumor of the ascending colon and a benign tumor emerging from the peritoneal lining, initially thought by the surgeon to be right-sided serosal carcinomatosis. But histopathological examination reveals that those multiple serosal nodules were benign granular cell tumors that have collided with highly aggressive transparietal signet-ring colon carcinoma. These results put the patient’s prognosis and therapeutic strategy in a different light than the clinical and intraoperative evaluation.

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MRI features of signet ring rectal cancer

et al. 2021

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Stage III and Metastatic Lymph Node Ratio Are the only Independent Prognostic Factors in Colorectal Signet-ring Cell Carcinoma Patients

Cited by 4 publications

References 34 publications

The Holocaust Is a Significant and Independent Risk Factor of Late-Onset Cancers: A Systematic Review of the Literature and Original Data on Jewish Israeli, Jewish Non-Israeli and Non-Jewish Non-Israeli Survivors

The Holocaust Is a Significant and Independent Risk Factor of Late-Onset Cancers: A Systematic Review of the Literature and Original Data on Jewish Israeli, Jewish Non-Israeli and Non-Jewish Non-Israeli Survivors

Collision Tumors of the Colon and Peritoneum: Signet-Ring Cell Carcinoma and Granular Cell Tumor

MRI features of signet ring rectal cancer

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