Stage Migration in Cervical Cancer Using the FIGO 2018 Staging System: A Retrospective Survival Analysis Using a Single Institution Patient Cohort. Is There a Will Rogers Phenomenon?

Abstract

The median follow-up time was 64 months (range 2 e 188 months). There were 35 patients (37.2 %) whose bifurcations were above L4-L5 interspace. The irradiation field superior border was L4 e L5 interspace in 81 patients (86.2 %). When comparing the superior border to the level of the aortic bifurcation, the border was 1 cm or more caudal in direction to the bifurcation in 28 patients (lower group) (29.8 %) and 1cm or more cranial in direction in 20 patients (21.3 %). NRLR occurred in 19 patients. Of these, 9 patients were initially pelvic node negative (N0), and the rest of the 10 patients were N1. The 5-year NRFS was 83.2 % for the N0 and 64.7 % for the N1, respectively (p Z 0.04). With regard to the superior border of the irradiated field to the level of the aortic bifurcation, the 5-year NRFS was 68.5 % in the lower group and 80.9 % in the other group (non-lower group) (p Z 0.21). When limited to the N0 group, the 5year NRFS was significantly worse in the lower group than in the nonlower group (67.5 % versus 91.3 %, p Z 0.02). Conclusion: The N1 group had higher NRLR compared to the N0 group. In the N0 group, it could prove prudent to keep a sufficient superior margin of the irradiation field to the aortic bifurcation.

Stage Migration in Cervical Cancer Using the FIGO 2018 Staging System: A Retrospective Survival Analysis Using a Single-Institution Patient Cohort

“…This work was previously presented as a poster at the American Society of Radiation Oncology (ASTRO) meeting in 2019. It was published in abstract form in the International Journal of Radiation Oncology, Biology, Physics on September 1, 2019 [ 7 ].…”