Stage-related correlations between immunoglobulins and complement components in preoperative sera from patients with gastric carcinoma

Cw, Janssen; Tönder, O.; Matre, R.

doi:10.1016/0277-5379(83)90092-5

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…This finding is in line with a previous report, where we described correlations between the concentrations of C1-INH and IgG, as well as Cl-INH and C4 in gastric cancer patients (Janssen et al, 1983). The preoperative ESR was nearly identical in the patients with and without recurrence.…”

Section: Discussionsupporting

confidence: 93%

“…We assume that Cl-INH reflects an additional prognostic feature appropriate to the tumour or the host. Our finding that the interval between surgery and death from recurrence had an inverse relation to the preoperative Cl-INH concentration also supports this assumption.We have previously described the preoperative serum concentrations of immunoglobulins (Ig) and some complement components (C), and the erythrocyte sedimentation rate (ESR) in relation to the extent of disease and prognosis in patients with gastric carcinoma (Janssen et al, 1983(Janssen et al, , 1985(Janssen et al, , 1987a. The levels of IgG decreased with advancing disease among those resected for cure, whereas Cl-esterase inhibitor (Cl-INH), C4 and ESR increased.…”

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confidence: 99%

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Serum C1-esterase inhibitor, an essential and independent prognosticator of gastric carcinoma

Lie²,

Maartmann-Moe³

et al. 1989

Br J Cancer

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Summary The preoperative concentrations of IgG were lower (P<0.002) and the concentrations of C4 and C1-INH higher (P<0.01 and P<0.001) in 29 patients with recurrence after potentially curative resection of gastric carcinoma, than in 31 patients alive and disease-free 5 years after surgery. These differences between the two groups of patients were consistent within each of six groups of disease extent. In each of the two groups of patients, the preoperative concentrations of IgG, C4 and Cl-INH had no significant variation with the extent of disease (P>0.05 or greater). Of our variables, Cl-INH was the most potent prognosticator and discriminated between patients with and without recurrence with 80% accuracy. Furthermore, the predictive prognostic value of Cl-INH at the time of surgery was superior to the prognostic value of the extent of disease (F values 27.00 and 12.69). Apparently, the preoperative Cl-INH concentration is an essential and independent prognostic parameter of gastric carcinoma. We assume that Cl-INH reflects an additional prognostic feature appropriate to the tumour or the host. Our finding that the interval between surgery and death from recurrence had an inverse relation to the preoperative Cl-INH concentration also supports this assumption.We have previously described the preoperative serum concentrations of immunoglobulins (Ig) and some complement components (C), and the erythrocyte sedimentation rate (ESR) in relation to the extent of disease and prognosis in patients with gastric carcinoma (Janssen et al., 1983(Janssen et al., , 1985(Janssen et al., , 1987a. The levels of IgG decreased with advancing disease among those resected for cure, whereas Cl-esterase inhibitor (Cl-INH), C4 and ESR increased. Patients with recurrence had lower preoperative concentrations of lgG and higher concentrations of Cl-INH than those alive and disease-free 21 years after surgery.The series of patients is now extended and the patients have been followed for 5 years, which permits the retrieval of further results. We have now searched for the exact predictive value of our variables as to recurrence or no-recurrence.

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Section: Discussionsupporting

confidence: 93%

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confidence: 99%

Serum C1-esterase inhibitor, an essential and independent prognosticator of gastric carcinoma

Lie²,

Maartmann-Moe³

et al. 1989

Br J Cancer

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“…Our finding that the preoperative IgG and C4 gave only limited or no prognostic information additional to C1-INH is explained by the correlations between these variables in preoperative sera (Janssen et al, 1983). The prognostic significance of C4 was slightly weaker than that of C1-INH.…”

Section: Discussionmentioning

confidence: 66%

The influence of the host on the course of gastric carcinoma

Lie²,

Bassøe³

et al. 1992

Br J Cancer

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Summary Immunoglobulins (Ig) and some complement components (C) were quantified in sera from patients with gastric carcinoma before surgery and at regular intervals during a 5-year follow-up.The (Woodruff, 1982). On the other hand, the effect of the host's immune state on the growth of cancer in vivo is not so apparent.We have studied patients with gastric carcinoma in a cumulative series starting in 1977. Some humoral immune factors in sera were quantified preoperatively and at regular intervals during a 5-year follow-up. Recently we showed that the preoperative levels of IgG and the complement components Cl-inhibitor (CI-INH) and C4 were essential prognosticators of gastric carcinoma and that they were independent of the extent of disease (Janssen et al., 1989 After surgery the patients entered a regular follow-up programme with examinations scheduled at every 3 months in the first year, later at 6-month intervals. The status of the series 5 years after surgery is shown in Table I.During the first 5 years after surgery nine patients had a second primary cancer. Colon cancer appeared in four, urogenital cancers also in four and squameous cell lung cancer in one patient.Twelve patients died from various causes without evidence of malignant disease at clinical or post-mortem (three patients) examination. One of them died from complications after a later laparotomy whereas 11 patients died from cardiopulmonary or cerebrovascular diseases.Three patients were lost on follow-up. They are all dead; at the last follow-up examination 1-3 months before death they were without signs of malignancy.Five years after surgery 46 patients were alive and without clinical signs of disease. During follow-up 50 patients had a clinical course consistent with recurrence of gastric carcinoma. These two groups of patients were compared to each other and to healthy individuals.The median time between surgery and clinical signs of recurrence was 12.3 (range 2-59) months and the median time between signs of recurrence and death was 2.5 (range 0-34) months.The age difference between the patients with and without recurrence was small and insignificant (P>0.05), and there was no significant sex difference between the groups (P>0.6). There was also no difference in the surgical procedure for total gastrectomy vs less extensive procedures (P<0.2) or splenectomy vs no splenectomy (P>0.4). Healthy individualsOne hundred and ten consecutive healthy individuals from an annual medical check-up was also used in the study. Individuals with chronic diseases or a history of cancer were ex-

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“…We closely read the full text of 171 articles, excluding 157 based on the criteria which were mentioned above. Finally, 10 articles including 18 studies published between 1976 and 2006 with 744 cancer patients and 528 healthy controls were considered eligible and were incorporated into the meta-analysis [20]; [21]; [22]; [23]; [24]; [25]; [26]; [27]; [28]; [29]. After joining research of our own (named Yang ZP, 2020), the characteristics of 19 studies included in the present meta-analysis are shown in Table 1.…”

Section: Literature Search Resultsmentioning

confidence: 99%

Complement Component 3 (C3) Concentrations in Cancer Patients: A Systematic Review and Meta-Analysis

Yang¹,

Yuan²,

Yang³

et al. 2020

Preprint

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BackgroundThe aim of this study was to investigate the association between the serum complement component 3 "C3" level and the patients with different types of cancer. Our study finding would ultimately provide reliable scientific conclusions to guide clinical practice. MethodsPubMed, Embase, The Chorane Library and Google Scholar were systematically searched to identify all studies on serum C3 concentrations in cancer patients published as of September 2019.Additionally, we conducted a clinical study on serum C3 in lung cancer patients and healthy people.The levels of serum complement C3 in 84 lung cancer patients and 30 healthy people were examined by ELISA. We used standardized mean differences (SMD) to report the pooled estimation, and I² statistics were calculated to examine the heterogeneity. For pooling estimates, a fixed effect metaanalysis was conducted on our studies. Two independent reviewers extracted relevant data and conducted deviation risk assessment. Our Meta-analysis was performed using STATA software and Review Manager 5.3. ResultsThe C3 levels of 83 lung cancer patients were 1.07 ± 0.34, and 30 healthy people were 0.95 ± 0.17 (the unit is g/l, keep two decimal places after the decimal point), and the p-value for t-test was 0.014 (<0.05). The overall C3 concentrations of cancer patients were significantly higher than the healthy control (SMD:0.30, 95%CI = 0.20 to 0.40 , p-value <0.00001). There was a certain degree of heterogeneity in the article, but it was acceptable (χ² = 31.89, p-value = 0.02, I²= 44%). ConclusionsConcentration analysis and this meta-analysis revealed that the serum C3 concentrations in cancer patients are significantly higher than that of healthy people. Further well-designed, large-scale, randomized controlled trials are needed to confirm this conclusion.

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Stage-related correlations between immunoglobulins and complement components in preoperative sera from patients with gastric carcinoma

Cited by 7 publications

References 23 publications

Serum C1-esterase inhibitor, an essential and independent prognosticator of gastric carcinoma

Serum C1-esterase inhibitor, an essential and independent prognosticator of gastric carcinoma

The influence of the host on the course of gastric carcinoma

Complement Component 3 (C3) Concentrations in Cancer Patients: A Systematic Review and Meta-Analysis

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