Selecting appropriate structural system for reinforced concrete (RC) buildings is essential in the design process to satisfy serviceability and strength requirements. Using ordinary analysis (OA) may result in inaccurate estimation of differential shortenings (DS) between vertical supporting elements which might lead to structural and architectural problems. Efficiency of staged analysis including time-dependent effects (SAT) has been recently recognized for the analysis of these buildings due to considering the sequential nature of construction. In this research, eight RC buildings with heights ranging between 35 and 175 m and various structural systems, namely rigid frames (RF), shear walls (SW), wall frames (WF), and tube in tube (TT), are analyzed. An assessment is conducted for the adequacy of three mitigation alternatives to decrease changes between DS estimated using OA and SAT. In Alternative 1, cross sections of all vertical elements (columns and shear walls) are increased by 50%. Alternative 2 is performed by iteratively proportioning the dimensions of internal columns without changing the cross sections of edge and corner vertical elements. One outrigger system is introduced along the height of buildings with WF and TT systems in Alternative 3. Analysis of the eight buildings is implemented by developing a numerical model considering the construction stages and time-dependent effects. The alternatives assessment is conducted by comparing differential displacements (DD), bending moments, and shearing forces before and after mitigation obtained from OA and SAT. The numerical results showed that Alternative 1 is not efficient in mitigating the differences between the OA and SAT for all the studied buildings. However, an optimum solution can be achieved using the Alternative 2 for all investigated systems. Also, Alternative 3 was found adequate in partially mitigating the differences between the two analyses for the buildings with WF and TT systems.