Accelerating growth of online-services expanding into the post-COVID world has strengthened competing for leadership in the key areas and changed the infrastructure of global economy’s capitalization. A study of system of economic relations enables better and more comprehensive understanding of the MNC’s place and role in the modern global economy. For the third consecutive year technology become a major industry from the point of view of market capitalization. However, from the point of view of an growth in the interest value such areas as healthcare, telecommunications and household services increased by 15% each in comparison with technological industry which growth in 2020 constituted only 6%. The last place among the leading global MNC from the industrial perspective is occupied by the financial area. In the mentioned segment multinational companies have undergone contraction of the market capitalization cost by 3% in total. Nevertheless, MNC among the Top-100 have managed to succeed much more than another companies in the mentioned sector. Changes in the global market in the 21st century have significantly increased the role of MNCs in sustainable infrastructure of the global economy.