Staging and Grading of Periodontitis: Setting Standards for Use in General Practice

Saleh, Muhammad H A; Dias, Debora R.; Araújo, Maurício G.; Wang, Hom‐Lay

doi:10.1007/s40496-022-00323-y

Cited by 1 publication

(1 citation statement)

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“…Participants were selected based on their medical history and a clinical examination during their initial visit. The diagnosis of generalized periodontitis at stages I–III was determined according to established criteria: the percentage of teeth affected by the disease, the level of epithelial attachment loss, and the presence of bleeding upon provocation [ 59 ].…”

Section: Methodsmentioning

confidence: 99%

Clinical Efficacy of Extracellular Vesicle Therapy in Periodontitis: Reduced Inflammation and Enhanced Regeneration

Puletic,

Velikic,

Maric

et al. 2024

IJMS

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Periodontitis, a prevalent inflammatory condition, affects the supporting structures of teeth, leading to significant oral health challenges. Traditional treatments have primarily focused on mechanical debridement, antimicrobial therapy, and surgery, which often fail to restore lost periodontal structures. Emerging as a novel approach in regenerative medicine, extracellular vesicle (EV) therapy, including exosomes, leverages nano-sized vesicles known for facilitating intercellular communication and modulating physiological and pathological processes. This study is a proof-of-concept type that evaluates the clinical efficacy of EV therapy as a non-surgical treatment for stage I–III periodontitis, focusing on its anti-inflammatory and regenerative potential. The research involved seven patients undergoing the therapy, and seven healthy individuals. Clinical parameters, including the plaque index, bleeding on probing, probing depth, and attachment level, were assessed alongside cytokine levels in the gingival crevicular fluid. The study found significant improvements in clinical parameters, and a marked reduction in pro-inflammatory cytokines post-treatment, matching the levels of healthy subjects, underscoring the therapy’s ability to not only attenuate inflammation and enhance tissue regeneration, but also highlighting its potential in restoring periodontal health. This investigation illuminates the promising role of EV therapy in periodontal treatment, advocating for a shift towards therapies that halt disease progression and promote structural and functional restoration of periodontal tissues.

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Section: Methodsmentioning

confidence: 99%