Staging and Survival Analysis for Nonsquamous Cell Carcinomas of the Larynx

Lin, Harrison W.; Bhattacharyya, Neil

doi:10.1097/mlg.0b013e3181671b3d

Cited by 69 publications

(59 citation statements)

References 28 publications

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“…Laryngeal cancer represents a disease with high incidence accounting for 2.4% of new malignancies worldwide every year [1]. Estimates of 139,230 new cases of laryngeal cancer worldwide are indicative of its importance [2] with a reported incidence of 45,900 cases in 2006 in Europe further illustrating this case [3].…”

Section: Introductionmentioning

confidence: 98%

Laryngeal cancer and passive smoking: the neglected factor?

Mallis

Jelastopulu

Mastronikolis

et al. 2010

Eur Arch Otorhinolaryngol

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In the present paper we investigate the relationship of environmental tobacco smoke (ETS) exposure to laryngeal cancer. 209 patients who were diagnosed with laryngeal cancer from 2000 to 2009 at the University Hospital of Patras, Western Greece, were reviewed with regard to patient age, disease stage at presentation, tumor differentiation, tobacco product use, alcohol consumption, occupation, and ETS exposure in the working environment. Pearson Chi-square method was used to determine the effect of ETS exposure on cancer stage, TNM classification and tumor differentiation in the dichotomized population (exposed vs. not exposed) and in groups of low, medium and high ETS exposure. ETS exposure in the working environment was found to significantly affect overall disease stage and T stage (p < 0.01) both in the dichotomic analysis and the group analysis. Minor significance was also noted for N stage (p = 0.047) in the exposure group analysis. Our data suggest that occupational ETS exposure presents a contributing risk factor for laryngeal cancer that requires further research to determine its significance.

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Section: Introductionmentioning

confidence: 98%

Laryngeal cancer and passive smoking: the neglected factor?

Mallis

Jelastopulu

Mastronikolis

et al. 2010

Eur Arch Otorhinolaryngol

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“…Some researchers believe that small cell neuroendocrine carcinoma of the larynx, much like its lung counterpart, should be viewed as a systemic disease 20 . According to a 2008 publication, using the National Cancer Institute's Surveillance and End Results database, researchers outlined that 5-year survival for small cell carcinoma for specific sites such as glottis and supraglottis was 15% and 24.1%, respectively 21 .…”

Section: Discussionmentioning

confidence: 99%

Primary neuroendocrine small cell carcinoma in larynx: case report and literature review

Evsei

Iosif

Enache

et al. 2017

Romanian Journal of Rhinology

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Background. Neuroendocrine tumors of the larynx represent a rare group of neoplasms characterized by pathological and biological heterogeneity. The histological and immunohistochemical diagnosis is the most important step in the appropriate management of these tumors and the prognosis varies according to histological types. Conventional anatomical and functional imaging can be complementary for diagnosis, staging and monitoring of treatment response. Material and methods. Here we report on a case of a laryngeal neuroendocrine small cell carcinoma occurring in a 67-year-old man who was referred to our clinic for clinical reevaluation, diagnosis and treatment. The clinical presentation, the histopathological and immunohistochemical examination and management of this kind of tumor are highlighted. Conclusion. Small cell neuroendocrine carcinomas are very aggressive neoplasms. Patients could benefit from surgery, but radiotherapy and chemotherapy remain the treatment of choice. Very low incidence of neuroendocrine tumors in the larynx and specifically very poor prognosis of neuroendocrine small cell carcinoma encouraged an extensive literature review.

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“…year [1]. Laryngeal cancer is the 20th most common cancer in Europe, with approximately 39,900 new cases diagnosed in 2012 (1% of the total) [2].…”

Section: Introductionmentioning

confidence: 99%

Survival of T4aN0 and T3N+ laryngeal cancer patients: a retrospective institutional study and systematic review

Khoueir

Matar

Farah

et al. 2015

American Journal of Otolaryngology

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Staging and Survival Analysis for Nonsquamous Cell Carcinomas of the Larynx

Abstract: Non-SCCs are more common in the supraglottic larynx. T-stage and N-stage influence survival more than histology alone for these cancers.

Cited by 69 publications

References 28 publications

Laryngeal cancer and passive smoking: the neglected factor?

Laryngeal cancer and passive smoking: the neglected factor?

Primary neuroendocrine small cell carcinoma in larynx: case report and literature review

Survival of T4aN0 and T3N+ laryngeal cancer patients: a retrospective institutional study and systematic review

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