Staging and treatment of Hodgkin's disease

Amiel, J. L.; Droz, Jean‐Pierre

doi:10.1016/0014-2964(78)90131-7

Cited by 7 publications

(3 citation statements)

References 3 publications

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“…The splenectomy per se may in some way have a deleterious effect, promoting the growth of Hodgkin's disease elsewhere (Bjorkholm et el 1975, Hancock et a1 1978. Another possibility is that the foci of Hodgkin's disease in the spleen may disappear in the absence of disease elsewhere, or that the foci diagnosed as Hodgkin' disease in the spleen may be a sign of reactive processes rather than a malignant one (Amiel & Droz 1978).…”

Section: Discussionmentioning

confidence: 99%

Is Staging Laparotomy of Therapeutic Value in Patients with Supradiaphragmatic Hodgkin's Disease, Clinical Stage IA‐IIA?

Høst

1981

Scandinavian Journal of Haematology

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Between 1968 and 1972, 123 patients with clinical stage (CS) IA and IIA Hodgkin's disease were seen. Staging laparotomy was introduced in June 1970. The impact of staging laparotomy on the prognosis has been evaluated by comparing the treatment results before and after the introduction of this procedure. The patients were treated only on the basis of CS before staging laparotomy, and mainly on the basis of pathological stage (PS) after the introduction of this procedure. Patients with stage IA to IIIA disease received radiotherapy alone with the extended field techniques, while patients with stage IVA disease had combination chemotherapy. After an observation time of 7 years there was no difference in survival between the two groups. The relapses occurred earlier in the patients treated after the introduction of staging laparotomy. It is shown that the survival is unaffected by staging laparotomy in the patients with Hodgkin's disease CS IA and IIA.

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Section: Discussionmentioning

confidence: 99%

Is Staging Laparotomy of Therapeutic Value in Patients with Supradiaphragmatic Hodgkin's Disease, Clinical Stage IA‐IIA?

Høst

1981

Scandinavian Journal of Haematology

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“…This might parallel the rare occurrence of tumour metastases in the spleen (McLure & Hwa Park, 1975). Alternatively, the histopathological picture in HD spleens may be a sign of a reactive rather than a malignant process (Amiel & Droz, 1978). As a 3rd alternative, splenic recurrences in non-splenectomized patients may occur late in the disease, thereby escaping detection during the period of observation.…”

Section: Prognosismentioning

confidence: 99%

Prognostic effect of early diagnostic splenectomy in Hodgkin's disease: a randomized trial

Askergren¹,

Björkholm²,

Holm³

et al. 1980

Br J Cancer

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Summary.-A randomized trial is reported which evaluates the effect of early diagnostic splenectomy on the prognosis of patients with Hodgkin's disease (HD) and uncertain prognosis. This was started in January 1973 and concluded in April 1979. Sixty-seven patients were entered in the study and 31 were randomized for splenectomy. All patients except 2 received total nodal irradiation, excluding the splenic and hepatic areas. After 40 months' observation there was no difference between the groups in respect of survival and the number of recurrences. However, relapses occurred earlier in the splenectomized patients. Pneumococcal septicaemia was recorded in 2 splenectomized patients. It is concluded that prognosis is not improved by diagnostic splenectomy in HD patients with uncertain prognosis and treated with total nodal irradiation.

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“…Thus, HLA genes are crucial for the development of autoimmune diseases, infectious diseases, and cancers. HL was the first human disease associated with HLA genes, and subsequent studies revealed that HLA alleles along with specific single-nucleotide variants (SNVs, formerly single-nucleotide polymorphisms; eg, rs6903608) are significantly associated with HL risk . In addition to the strong association between HLA and HL, genetic variants in non-HLA regions have been reported, including rs4459895 ( LPP [OMIM 600700]) and rs1432295 ( REL [OMIM 164910]), among others.…”

Section: Introductionmentioning

confidence: 99%

Association of Single-Nucleotide Variants in the Human Leukocyte Antigen and Other Loci With Childhood Hodgkin Lymphoma

et al. 2022

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IMPORTANCEStudies focusing on genetic susceptibility of childhood Hodgkin lymphoma (HL) are limited. OBJECTIVES To identify genetic variants associated with childhood-onset HL vs adult-onset HL. DESIGN, SETTING, AND PARTICIPANTS This genetic association study was performed with 3 cohorts: the St Jude Lifetime Cohort Study (SJLIFE), initiated in 2007 with ongoing follow-up, and the original and expansion cohorts of the Childhood Cancer Survivor Study (CCSS), initiated in the 1990s with ongoing follow-up. Results of these genome-wide association studies (GWASs) were combined via meta-analysis. Data were analyzed from June 2021 to June 2022. MAIN OUTCOMES AND MEASURES Childhood HL was the focused outcome. Single-nucleotide variant (SNV, formerly single-nucleotide polymorphism) array genotyping and imputation were conducted for the CCSS original cohort, and whole-genome sequencing was performed for the SJLIFE and CCSS expansion cohort.RESULTS A total of 1286 HL cases (mean diagnosis [SD] age, 14.6 [3.9] years), 6193 non-HL childhood cancer cases, and 369 noncancer controls, all of European ancestry, were included in the analysis. Using step-wise conditional logistic regression, the odds ratios (ORs) for each of the 3 independent SNVs identified in the human leukocyte antigen (HLA) locus were 1.80 (95% CI, 1.59-2.03;

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Staging and treatment of Hodgkin's disease

Cited by 7 publications

References 3 publications

Is Staging Laparotomy of Therapeutic Value in Patients with Supradiaphragmatic Hodgkin's Disease, Clinical Stage IA‐IIA?

Is Staging Laparotomy of Therapeutic Value in Patients with Supradiaphragmatic Hodgkin's Disease, Clinical Stage IA‐IIA?

Prognostic effect of early diagnostic splenectomy in Hodgkin's disease: a randomized trial

Association of Single-Nucleotide Variants in the Human Leukocyte Antigen and Other Loci With Childhood Hodgkin Lymphoma

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