Staging laparotomy with splenectomy in children and adolescents with Hodgkin's disease

Green, Daniel M.; Ghoorah, Jayah; Douglass, Harold O.; Allen, James E.; Berjian, R; Jewett, Theodore C.; Brecher, Martin L.; Henderson, Edward S.; Freeman, Arnold I.

doi:10.1016/s0305-7372(83)80030-9

Cited by 26 publications

(2 citation statements)

References 85 publications

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“…Total resulting in assignment of the patient to a more advanced stage [28,29]. A compilation of the results of staging laparotomy in several series of pediatric patients identified the most common sites of unsuspected disease as the spleen (39%), splenic hilar nodes (28%), celiac nodes (17%), periportal nodes (15%), and paraaortic nodes ( 15 %) [30]. If a staging laparotomy is performed, female patients should have their ovaries repositioned to minimize radiation exposure should abdominal or pelvic irradiation be required.…”

Section: Stagingmentioning

confidence: 99%

Malignant lymphomas in children and adolescents

Brecher

1986

Seminars in Surgical Oncology

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Malignant lymphomas constitute the third most common group of childhood cancers in the United States. Hodgkin's disease (HD) exhibits a bimodal age peak, with the first peak occurring in the 15-34-year age group. Nodular sclerosis is the most common histologic subtype of HD seen in children. The disease tends to be primarily supradiaphragmatic at presentation. Accurate staging is essential for determination of appropriate therapy. Staging laparotomy with splenectomy is indicated for those patients with clinically localized disease whose therapy may be altered by pathologic staging. Radiation therapy is curative in the great majority of patients with localized disease. Multimodality therapy has been employed with increasing success in patients with advanced disease. The late sequelae of therapy must be considered in the design of optimum therapeutic regimens. More than 90% of non-Hodgkin's lymphoma (NHL) in childhood can be grouped into one of three histologic subtypes: lymphoblastic, undifferentiated, and diffuse large cell type. Lymphoblastic lymphomas most commonly present with mediastinal involvement. The majority of nonlymphoblastic lymphomas arise within the abdomen. Because of the tendency of NHL for extralymphatic dissemination, systemic therapy is always required. Treatment is determined by stage and histology. Significant improvements in survival rates have resulted from the development of effective combination chemotherapy programs. Cure rates in excess of 90% can be expected in children with localized disease. The outlook for children with advanced disease of undifferentiated histology remains poor. The presence of central nervous system involvement at diagnosis is a particularly ominous sign.

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Section: Stagingmentioning

confidence: 99%

Malignant lymphomas in children and adolescents

Brecher

1986

Seminars in Surgical Oncology

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“…Η χειρουργική σταδιοποίηση είχε εφαρµοστεί στο παρελθόν και τα αποτελέσµατα στο 35% των ασθενών είχαν δείξει περισσότερο εκτεταµένη νόσο σε σύγκριση µε τις απεικονιστικές µεθόδους (Green et al 1983 (Kelly et al 2002).…”

Section: ∆ιαφορική διάγνωσηunclassified

Παράγοντες Κινδύνου Για Λεμφώματα Της Παιδικής Ηλικίας

Ανδρή¹

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Average annual percent change): Μέση ετήσια εκατοστιαία µεταβολή. ACCIS (Automated Childhood Cancer Informatio System): Σύστηµα αυτόµατης πληροφόρησης για τον καρκίνο της παιδικής ηλικίας. AIDS: Σύνδροµο επίκτητης ανοσολογικής ανεπάρκειας. ΑΛΜΚ: Αναπλαστικό λέµφωµα από µεγάλα κύτταρα. ΒΛ: Burkitt λέµφωµα. CMV: κυταροµεγαλοϊός. CT: Αξονική τοµογραφία. ∆ΛΜΒΛ: ∆ιάχυτο λέµφωµα από µεγάλα Β-λεµφοκύτταρα. EBV: Ιός Epstein Barr. FDP-PET: Ποσιτρονική τοµογραφία. HHV-6: Ανθρώπινος ερπητοϊός -6. HIV: Ιός ανοσολογικής ανεπάρκειας του ανθρώπου. ΗΛ: Hodgkin λέµφωµα. IFNγ Interferon-gamma: Ιντερφερόνη-γ. ΙARC (International Agency for Research on Cancer) : ∆ιεθνής Υπηρεσία για την Έρευνα του Καρκίνου. IGF-I (insulin-like growth factor-I): Παράγοντας ανάπτυξης ινσουλίνης τύπου I. IGF-II (insulin-like growth factor-II): Παράγοντας ανάπτυξης ινσουλίνης τύπου II. ΚΝΣ: Κεντρικό νευρικό σύστηµα.

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Individual risk of abdominal disease in patients with stages I and II supradiaphragmatic Hodgkin's disease. A rule index based on 341 laparotomized patients

Cruz

Cárdenes

Otero

et al. 1990

Cancer

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A multivariate analysis of the prognostic factors for clinical Stages I and II supradiaphragmatic Hodgkin's disease was carried out with a logistic regression model in 341 patients. The proportion of patients with positive staging laparotomy was greater in males, in individuals with several sites involved, mixed cellularity (MC) or lymphocyte depletion (LD) histologic types, systemic symptoms, or in patients with lower cervical involvement and higher erythrocyte sedimentation rate (ESR), serum copper, and LDH levels. Histology, presence of systemic symptoms (fever and sweats), and number of involved nodal regions were independent predictors of positive laparotomy. Mediastinal involvement is correlated to a significantly lower risk of positive laparotomy. Based on these observations, the individual risk for each patient of occult abdominal disease has been defined.

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Staging laparotomy with splenectomy in children and adolescents with Hodgkin's disease

Cited by 26 publications

References 85 publications

Malignant lymphomas in children and adolescents

Malignant lymphomas in children and adolescents

Παράγοντες Κινδύνου Για Λεμφώματα Της Παιδικής Ηλικίας

Individual risk of abdominal disease in patients with stages I and II supradiaphragmatic Hodgkin's disease. A rule index based on 341 laparotomized patients

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