Staging of carcinoma of bilharzial bladder

Ghoneim, Mohamed A.; Mansour, Manar; Bolkainy, M.N. El

doi:10.1016/s0090-4295(74)80057-9

Cited by 16 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ghoneim [26] explained the late presentation by the overlapping of symptoms of simple bilharzial cystitis with early malignant cystitis. The results of clinical staging were compared with the pathological findings and showed a clinical error of 37%, with a tendency for underestimation [40]. In a recent study of 608 SCC from bilharzial bladders, the histopathological staging was P1 in 2.6%, P2 in 10.5%, P3 in 80% and P4 in 6.9%[33]; the grading of tumours in the same study showed grade I in 49.7%, grade II in 33.2% and grade III in 17.1%[33].…”

Section: Scc In the Bilharzial Bladdermentioning

confidence: 99%

Squamous cell carcinoma of the bladder: pathology, diagnosis and treatment

2003

View full text Add to dashboard Cite

Squamous cell carcinoma (SCC) can occur in both nonbilharzial and bilharzial bladders; the two subtypes differ in epidemiology, pathogenesis and clinicopathological features. The nonbilharzial type occurs in Western countries and represents < 5% of all vesical tumours; it occurs most often in the seventh decade with a slight male predominance. The principal predisposing factor is prolonged indwelling urethral catheterization in patients with spinal cord injury and the main symptom is haematuria. Patients are usually diagnosed at an advanced stage and most of the tumours are of moderate and high grades. At cystoscopy tumours are predominantly ulcerative and commonly involve the trigone and lateral walls. Although distant metastasis is infrequent (8–10%) the prognosis is grave and most patients die after failure of locoregional control; radical cystectomy provides the best therapy. To avoid nonbilharzial SCC, patients with spinal cord injury should be free of catheterization if possible. The outcome can be improved by early detection with frequent cytology, cystoscopy and biopsy. Bilharzial SCC occurs commonly in the Middle East, South‐east Asia and South America where schistosomiasis is endemic. In an Egyptian series SCC represented 59% of 1026 cystectomy specimens. The tumour is diagnosed in the fifth decade, and five times more common in men than women. Bladder carcinogenesis is probably related to bacterial and viral infections, commonly associated with bilharzial infestation rather than the parasite itself. The presentation is often with irritative bladder symptoms and haematuria, and many patients present at an advanced stage, although most tumours are of low and moderate grades. At cystoscopy tumours are predominantly nodular and usually arise from the upper vesical hemisphere. Lymph‐node metastasis occurs in ≈ 19% and significantly decreases survival; radical cystectomy remains the main treatment, giving a 5‐year survival rate of 50%. Early detection improves the therapeutic yield and prevention is possible by combining snail control and mass therapy of the infested rural population by oral antibilharzial drugs.

show abstract

Section: Scc In the Bilharzial Bladdermentioning

confidence: 99%

Squamous cell carcinoma of the bladder: pathology, diagnosis and treatment

2003

View full text Add to dashboard Cite

show abstract

“…Most prognostic studies of bladder cancer have dealt with survival (Osborn et al, 1982;England et al, 1981;Kishi et al, 1981;Cifuentes Delatte et al, 1982) and a minority with recurrence or metastasis (Dalesio et al, 1983;Pocock et al, 1982). Moreover these prognostic studies have generally been concerned with 'Western' bladder cancer (Osborn et al, 1982;Dalesio et al, 1983;Pocock et al, 1982) while few studies have dealt with bilharzial bladder cancer (Ghoneim et al, 1972(Ghoneim et al, ,1976(Ghoneim et al, ,1979Sherif and Ibrahim, 1983 England et al, 1981;Ghoneim et al, 1972Ghoneim et al, ,1976Smith & Whitmore, 1981;Varkarakis et al, 1975;Ballanger & Ballanger, 1982). Our study did not prove the prognostic value of multiplicity or histopathology of the tumour; some authors concur with this conclusion while others dissent (Ghoneim et al, 1979;Kishi et al, 1981).…”

Section: Discussionmentioning

confidence: 99%

A model to predict the outcome of the bilharzial bladder cancer patient after radical cystectomy

Rafla

Ibrahim²,

Sherif³

et al. 1987

Br J Cancer

View full text Add to dashboard Cite

Using a discriminant analysis technique to take into account the inter-relationships between the factors, it was found that tumour grade was the most important prognostic factor followed, in order of importance, by tumour stage, renal insufficiency, size of the tumour and lymph node involvement. Moreover, a simplified score for prognosis was determined: X= 10 grade (1 to 3) + 5 stage (1 to 4) + 6 renal insufficiency (Y/N) +1 diameter of the tumour (cm) + 4 lymph node involvement (Y/N). The larger the score, the poorer the prognosis.

show abstract

The impact of schistosomiasis on the pathology of bladder carcinoma

El-Bolkainy¹,

Mokhtar²,

Ghoneim

et al. 1981

Cancer

225

106

View full text Add to dashboard Cite

In a series of 1095 Egyptian patients with carcinoma of the bladder treated by radical cystectomy, 902 cases (82.4%) contained schistosome eggs in the specimens, and 193 (17.6%) were egg-negative. The different tumor parameters were compared in these subgroups to explore any differences that could be related to schistosomal infestation. In egg-positive cases, the tumor developed at a younger age (46.7 years) than in egg-negative cases (53.2 years). Squamous cell carcinoma, commonly of low grade, predominated in the egg-positive group. No difference was observed in the frequency of tumor stages or lymph node metastases between the two subgroups. The limited tendency to distant spread in schistosomal bladder cancer, despite its advanced local stage, is accounted for by the high frequency of low grade tumors rather than the limiting effect of local schistosomal tissue reactions.

show abstract

Staging of carcinoma of bilharzial bladder

Cited by 16 publications

References 7 publications

Squamous cell carcinoma of the bladder: pathology, diagnosis and treatment

Squamous cell carcinoma of the bladder: pathology, diagnosis and treatment

A model to predict the outcome of the bilharzial bladder cancer patient after radical cystectomy

The impact of schistosomiasis on the pathology of bladder carcinoma

Contact Info

Product

Resources

About