Staging of esophageal carcinoma: Length of tumor and number of involved regional lymph nodes. Are these independent prognostic factors?

Bollschweiler, Elfriede; Baldus, Stephan; Schröder, Wolfgang; Schneider, Paul M.; Hölscher, A. H.

doi:10.1002/jso.20569

Cited by 141 publications

(130 citation statements)

References 33 publications

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“…Within pelvic and periaortic lymphadenectomy, the number of LNs assessed depends on the attitude of the surgeon and on the accuracy of the pathological evaluation undertaken. The ratio metastatic to examined LNs may obviate the possible confounding effect [18]. Nigro et al showed that patients with an LNR < 0.1 fared significantly better than those who had an LNR > 0.1 [19].…”

Section: Resultsmentioning

confidence: 99%

Impact of the Ratio of Metastatic to Examined Lymph Nodes on the Survival of Early-Stage Cervical Cancer Patients

Metindir¹,

Bilir²

2009

Oncol Res Treat

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Background: The aim of the study was to determine the impact of the ratio of metastatic to examined lymph nodes (LN) on the survival of early-stage cervical cancer patients. Methods: A retrospective review was performed of all patients undergoing primary radical hysterectomy and pelvicparaaortic lymphadenectomy for stage I–II cervical cancer at the Ankara Oncology Hospital from 1995 to 2000. Survival was determined by Kaplan-Meier method and differences were assessed by log-rank test. Results: A total of 2,085 LN were examined. Nodal metastasis was found in 22.1% of the patients. Patients with zero involved LN had a 5-year survival of 89.19%, while patients with 1 positive LN and > 1 positive LNs had a 5-year survival of 100 and 76.92%, respectively. The difference in survival among these three groups was not statistically significant. The 5-year survival rates according to the metastatic/examined LN ratio (LNR) were 75, 90, and 89.19% in the groups of patients with LNR >10, 1–10, and 0%, respectively. The difference in survival among these three groups was not statistically significant. Conclusions: This factor might be helpful for a better prognostic discrimination of patients with metastatic LN. The stratification of node-positive cervical cancer for prognostic and treatment purposes warrants further investigation.

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Section: Resultsmentioning

confidence: 99%

Impact of the Ratio of Metastatic to Examined Lymph Nodes on the Survival of Early-Stage Cervical Cancer Patients

Metindir¹,

Bilir²

2009

Oncol Res Treat

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“…In a study of 2,597 patients from the SEER database, patients classified as N0 had fewer lymph nodes identified than those classified as N1 [7]. Other investigators have reported a strong correlation between the number of lymph nodes examined and number involved [8]. For example, patients who were N0 had a mean lymph node count of 14.2 AE 7.1 whereas the lymph node count was 18.0 AE 9.3 in patients found to have lymph node metastases [9].…”

Section: Extent Of Lymphadenectomy and Accuracy Of Stagingmentioning

confidence: 98%

The role of lymphadenectomy in esophageal cancer

Darling

2008

Journal of Surgical Oncology

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Lymph node metastases are common in esophageal cancer and are associated with a poor prognosis. Resection and examination of 15-18 lymph nodes is required for adequate staging of esophageal cancer. Improved survival is associated with involvement of five or fewer nodes or lymph node ratio (LNR) of < 0.10-0.20. More extensive lymph node dissection during esophagectomy offers improved staging but may also provide therapeutic benefit in terms of control of locoregional disease and possibly improved overall survival.

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“…found that 18 LNs should be removed for adequate staging purposes based on data from a single institution study of 336 cases of stage I to stage IV esophageal carcinoma. In a study of 198 cases (also including all tumor and LN stages), Bollschweileret al [22]. suggested that 15 LNs be sampled to minimize misclassification of LN-positive patients.…”

Section: Transhiatal Versus Transthoracic Esophagectomymentioning

confidence: 99%

Total Oesophagectomy for Squamous Cell Carcinoma With or Without Standard Two Field Node Dissection - A Prospective Study

Chheda

Pillai

Shah

2013

Indian J Surg Oncol

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Staging of esophageal carcinoma: Length of tumor and number of involved regional lymph nodes. Are these independent prognostic factors?

Abstract: A revision of the TNM classification for esophageal carcinoma should subdivide the pN1-category according to the number of LNM.

Cited by 141 publications

References 33 publications

Impact of the Ratio of Metastatic to Examined Lymph Nodes on the Survival of Early-Stage Cervical Cancer Patients

Impact of the Ratio of Metastatic to Examined Lymph Nodes on the Survival of Early-Stage Cervical Cancer Patients

The role of lymphadenectomy in esophageal cancer

Total Oesophagectomy for Squamous Cell Carcinoma With or Without Standard Two Field Node Dissection - A Prospective Study

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