Staging of supratentorial hemispheric glioma using tumour extension, histopathological grade and extent of surgical resection

Abstract

A 'TGS' classification for supratentorial brain glioma is proposed, based on three parameters: tumour extension (T), histopathological grade (G) and extent of surgical resection (S). Two groups of patients were analysed: the first (n = 137) had tumour submitted to stereotactic biopsy; the second (n = 60) had malignant glioma operated on by craniotomy and tumor resection. All three staging parameters significantly influenced survival. Histopathological grade was the most significant factor, and the only independent variable on multivariate analysis, followed by extent of tumour and then extent of surgical resection. The data support the applicability of the proposed parameters for a staging classification of hemispheric brain glioma.

The level of manganese superoxide dismutase content is an independent prognostic factor for glioblastoma. Biological mechanisms and clinical implications

“…As said above, the difference among these two groups is statistically significant (Mantel-Cox P = 0.0275). These observations confirm literature data (Devaux et al, 1993;Iacoangeli et al, 1993;Kowalczuk et al, 1997), and ensure that the tumour population we are dealing with is representative of the general population of patients suffering from brain tumour that are in the conditions of undergoing surgery. When the survival of these patients is stratified according to MnSOD level in the tumour, a strong link of these levels and prognosis can be observed.…”

Practicability of magnetoencephalography-guided neuronavigation

“…The extent of tumor removal is one of several factors thought to influence the prognosis of patients with brain tumors [4,5,6,7,8,9]. Survival appears to be longer in patients in whom a gross total resection of the tumor could be achieved as compared to patients in whom only a subtotal resection or a biopsy could be obtained.…”

Limitations of stereotactic biopsy in the initial management of gliomas

“…It is generally accepted that the extent of tumor resection, tumor histology, and the patient's age are major prognostic factors for patients with gliomas (Abi-Said et al, 1999;Danks et al, 1995;Devaux et al, 1993;Iacoangeli et al, 1993;Janny et al, 1994;Levin et al, 1995;Nitta and Sato, 1995;Piepmeier et al, 1996;Pollack et al, 1995;Rostomily et al, 1994;Vecht et al, 1990;Winger et al, 1989). 4 Extent of resection is the only one of these key variables that neurosurgeons can affect.…”