Staging von Oropharynxkarzinomen

Beltz, Anna; Gößwein, Dorothee; Zimmer, S; Stauber, Roland H.; Hagemann, Jan; Strieth, Sebastian; Matthias, Christoph; Künzel, Julian

doi:10.1007/s00106-018-0499-0

Cited by 9 publications

(5 citation statements)

References 25 publications

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“…In addition to the widely used diagnostic methods involved in postoperative histopathologic examination, various imaging techniques can be applied, such as ultrasound, magnetic resonance imaging (MRI), and computed tomography (CT). Clinical diagnosis of ENE of lymph node metastases presupposes that clear, defined criteria are met (8). Clinical or radiologic signs of tumor invasion alone (including the skin and surrounding soft tissue) as well as clinical symptoms of neural involvement (e.g., paresis of cranial nerves) are defined as clinical ENE in the new TNM classification (9).…”

Section: Imaging and Clinical Predictors In Diagnosing Extranodal Extmentioning

confidence: 99%

“…The following criteria are used for radiologic diagnosis of ENE for both CT and MRI: presence of irregular nodal capsular enhancement, loss of distinct nodal margins and infiltration into adjacent structures (fatty tissue, muscle, blood vessels) (1,10,11). Generally speaking, however, the limited sensitivity and specificity of the methods used in relation to the clinical diagnosis of ENE need to be discussed (8). For example, Steinkamp et al showed in several publications a sensitivity of ∼80.9% with specificity of 72.2% for CT investigations and sensitivity of ∼74.4% and specificity of 72.2% for MRI imaging (1,12,13).…”

Section: Imaging and Clinical Predictors In Diagnosing Extranodal Extmentioning

confidence: 99%

“…Numerous studies in the past have shown that the presence of ENE additionally worsens the prognosis of patients with HNSCC (1,8,(46)(47)(48)(49)(50). In a 2006 meta-analysis by Dunne et al involving 1,620 patients with diagnosed HNSCC and lymph node metastasization, 5-year overall survival deteriorated to 30.7% in the presence of ENE compared to 58.1% in the absence of ENE (1,50).…”

Section: Extranodal Extension As Risk and Prognostic Factormentioning

confidence: 99%

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Significance of Extranodal Extension in Surgically Treated HPV-Positive Oropharyngeal Carcinomas

et al. 2020

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Section: Imaging and Clinical Predictors In Diagnosing Extranodal Extmentioning

confidence: 99%

Section: Imaging and Clinical Predictors In Diagnosing Extranodal Extmentioning

confidence: 99%

Section: Extranodal Extension As Risk and Prognostic Factormentioning

confidence: 99%

See 1 more Smart Citation

Significance of Extranodal Extension in Surgically Treated HPV-Positive Oropharyngeal Carcinomas

et al. 2020

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“…As shown in the univariate Cox analysis, tumor stage, N stage, and risk level are all poor prognostic indicators of HNSCC. As the traditional tumor stage has certain limitations in predicting the prognosis of HNSCC ( Beltz et al, 2018 ), we established a prognostic model that combines six-gene signatures related to metastasis with tumor stage in HNSCC using multivariate Cox analysis. Next, the nomogram constructed based on this model provided a more intuitive evaluation tool.…”

Section: Discussionmentioning

confidence: 99%

Establishment and Validation of a Comprehensive Prognostic Model for Patients With HNSCC Metastasis

Shen

et al. 2021

Front. Genet.

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ObjectiveTo identify biomarkers related to head and neck squamous cell carcinoma (HNSCC) metastasis and establish a prognostic model for patients with HNSCC.MethodsHNSCC mRNA expression data of metastasis and non-metastatic samples were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. After screening the differentially expressed genes (DEGs) in the two datasets, a prognostic model, including clinical factors and biomarkers, was established, and verified in 36 samples of HNSCC by quantitative real-time transcription (qRT)-PCR. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene sets enrichment analysis (GSEA) were consulted to explore the functions of the DEGs.ResultsIn total, 108 DEGs were identified. GSEA, GO, and KEGG analyses showed that these DEGs were mainly involved in the proliferation and metastasis of HNSCC. Six genes that were significantly related to metastasis, immune cell infiltration and prognosis were further identified to construct a prognostic gene signature. The reliability of the gene signature was verified in 36 samples of HNSCC. A prognostic model, including tumor stage, risk level, and a nomogram for prediction were further established. Receiver operating characteristic (ROC) analysis, decision curve analysis (DCA), C-index, and calibration plots showed that the model and nomogram perform well.ConclusionWe constructed a six-gene signature and a nomogram with high performance in predicting the prognosis of patients with HNSCC metastasis.

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“…In the new World Health Organization (WHO) classification from 2017 [1,2], oropharyngeal tumors are found to be so important, that they are separated in a new chapter, being divided from tumors in the oral cavity, in which they were incorporated in previous classification from 2005. These tumors are now classified as p16 positive, associated with Human Papillomavirus (HPV) infection [3,4,5], and p16 negative, associated with long term cigarette smoking and alcohol abuse [6,7].…”

Section: Introductionmentioning

confidence: 99%

p16 status of oropharyngeal and oral cavity squamous cell carcinomas: A single institution experience

et al. 2020

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Introduction/Objective. New World Health Organization Classification of Head and Neck Tumours from 2017 has introduced significant changes, mainly considering tumors in oropharyngeal region. New entities of HPV positive and negative squamous cell carcinomas have been acknowledged, not only based on presence of active viral infection and different tumor markers expression, but also because of their different histopathology, staging assessment and prognosis. A retrospective study has been conducted, in order to determine p16 positivity in squamous cell carcinomas in oropharynx and in oral cavity, and to see whether they differ in gender and age distribution. Methods. Presence of viral infection was verified based on p16 immunochemistry staining, p16 being the surrogate marker for HPV infection. 177 cases of squamous cell carcinomas in oropharynx and oral cavity, found in archives of Histopathology laboratory of Clinic for Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia have been revised. Results. Out of 177 cases, 50 (28.2%) were p16 positive. Compared with carcinomas in oral cavity, p16 carcinomas were significantly more common in oropharynx (34.3% in oropharynx, compared to 10.3% in oral cavity). Carcinomas in both regions were mostly associated with male gender (88.1% of all cases were in males), but p16 positivity was more common in females (11 out of 21 cases, 52.4%). The most common location of p16 positive carcinomas were palatine tonsils (41.03% of tonsillar carcinomas were p16 positive). Conclusion. P16 positive squamous cell carcinomas were the most numerous in oropharynx, i.e. palatine tonsils, and were more common in females

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Staging von Oropharynxkarzinomen

Cited by 9 publications

References 25 publications

Significance of Extranodal Extension in Surgically Treated HPV-Positive Oropharyngeal Carcinomas

Significance of Extranodal Extension in Surgically Treated HPV-Positive Oropharyngeal Carcinomas

Establishment and Validation of a Comprehensive Prognostic Model for Patients With HNSCC Metastasis

p16 status of oropharyngeal and oral cavity squamous cell carcinomas: A single institution experience

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