Staging with computed tomography of patients with colon cancer

Malmstrøm, Marie Louise; Brisling, Steffen; Klausen, TW; Săftoiu, Adrian; Perner, Trine; Vilmann, Peter; Gögenur, Ismail

doi:10.1007/s00384-017-2932-3

Cited by 33 publications

(32 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This In concordance with a systematic review [20] and a Danish single-centre study [21] we found that it remains a challenge to correctly identify patients with locally advanced disease. In our study only 61% of patients with locally advanced disease and 85% without locally advanced disease were correctly identified on MDCT.…”

Section: Discussion and Con Clus Ionssupporting

confidence: 89%

Accuracy of preoperative staging with multidetector computed tomography in colon cancer

et al. 2020

View full text Add to dashboard Cite

Aim: Multidetector computed tomography (MDCT) is the main preoperative decisionmaking tool in colon cancer treatment, thus the validation of daily clinical practice is warranted. The only published study validating the accuracy of MDCT in a national cohort was performed more than a decade ago. With neoadjuvant chemotherapy for patients with preoperatively assessed locally advanced cancer and the emergence of other personalized treatments we aimed to validate the accuracy of MDCT in a national cohort. Method: The study is based on the Danish Colorectal Cancer Group (DCCG) database and included all Danish patients diagnosed with primary colon adenocarcinoma between January 2015 and December 2018. The primary study outcome was the accuracy of MDCT in identifying patients with locally advanced disease. The secondary outcomes were the accuracy of predicting UICC Stage I based on predicting the tumour category (pT3-T4 versus pT1-T2) and lymph node metastasis. Results: A total 3465 patients were included in the analyses regarding locally advanced colon cancer. The sensitivity and specificity were 0.61 (0.58-0.64) and 0.85 (0.83-0.86), respectively, for CT to predict locally advanced disease. The sensitivity and specificity were 0.63 (0.59-0.66) and 0.80 (0.78-0.81), respectively, for predicting UICC Stage I in 4496 patients. Thirty six per cent of the patients assessed as having locally advanced disease and 58% assessed as Stage I were misclassified by MDCT. Conclusion: The present standard in Denmark questions whether the implementation of personalized medicine such as neoadjuvant adjuvant chemotherapy and tailor-made resections based on MDCT is justified.

show abstract

Section: Discussion and Con Clus Ionssupporting

confidence: 89%

Accuracy of preoperative staging with multidetector computed tomography in colon cancer

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The selected papers are summarized in Table 3 82‐93 . For T staging (Table 3A), Chen et al revealed that dual‐energy CT showed a high accuracy, with a sensitivity of 90% and specificity of 97% 83 .…”

Section: Resultsmentioning

confidence: 99%

“…For lymph node staging (Table 3B), the sensitivity was found to range from 44% to 73%, and the specificity ranged from 41% to 84%. [84][85][86][87][88][89][90] The accuracies of these studies were around 50%-60%. PET showed a relatively high specificity of 84%, but a sensitivity of only 44%.…”

Section: Lymph Node Stagingmentioning

confidence: 99%

Clinical TNM staging for esophageal, gastric, and colorectal cancers in the era of neoadjuvant therapy: A systematic review of the literature

Shimada

Fukagawa

Haga

et al. 2021

Annals of Gastroent Surgery

View full text Add to dashboard Cite

show abstract

“…For adrenal incidentaloma, non-enhanced CT and HU of ROI can be used to discriminate benign from malignant lesions (14,16). In colon cancer, ceCT analysis in the portal venous phase is the current standard method for initial disease staging (30). Ravanelli et al used texture analysis of ceCTs for response prediction in patients treated with bevacizumab, with a remarkable correlation of OS and texture analysis in this subgroup of patients (31).…”

Section: Discussionmentioning

confidence: 99%

Computertomography-Based Prediction of Complete Response Following Neoadjuvant Chemoradiotherapy of Locally Advanced Rectal Cancer

Маслова

Herden²,

Schork

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

Therapeutic strategies for patients with locally advanced rectal cancer (LARC) who are achieving a pathological complete response (pCR) after neoadjuvant radio-chemotherapy (neoCRT) are being increasingly investigated. Recent trials challenge the current standard therapy of total mesorectal excision (TME). For some patients, the treatment strategy of “watch-and-wait” seems a preferable procedure. The key factor in determining individual treatment strategies following neoCRT is the precise evaluation of the tumor response. Contrast-enhanced computer tomography (ceCT) has proven its ability to discriminate benign and malign lesions in multiple cancers. In this study, we retrospectively analyzed the ceCT based density of LARC in 30 patients, undergoing neoCRT followed by TME. We compared the tumors´ pre- and post-neoCRT density and correlated the results to the amount of residual vital tumor cells in the resected tissue. Overall, the density decreased after neoCRT, with the highest decrease in patients achieving pCR. Densitometry demonstrated a specificity of 88% and sensitivity of 68% in predicting pCR. Thus, we claim that ceCT based densitometry is a useful tool in identifying patients with LARC who may benefit from a “watch-and-wait” strategy and suggest further prospective studies.

show abstract

Staging with computed tomography of patients with colon cancer

Cited by 33 publications

References 25 publications

Accuracy of preoperative staging with multidetector computed tomography in colon cancer

Accuracy of preoperative staging with multidetector computed tomography in colon cancer

Clinical TNM staging for esophageal, gastric, and colorectal cancers in the era of neoadjuvant therapy: A systematic review of the literature

Computertomography-Based Prediction of Complete Response Following Neoadjuvant Chemoradiotherapy of Locally Advanced Rectal Cancer

Contact Info

Product

Resources

About