Staging Workup, Sentinel Node Biopsy, and Follow-up Tests for Melanoma

Johnson, Timothy M.; Bradford, Carol R.; Gruber, Stephen B.; Sondak, Vernon K.; Schwartz, Jennifer

doi:10.1001/archderm.140.1.107

Cited by 41 publications

(26 citation statements)

References 51 publications

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“…But it is now apparent that the sensitivity and specificity of a chest radiograph and other baseline tests in asymptomatic patients are exceedingly low. [3][4][5][6][7][8][9][10][11][12][13][44][45][46][47][48][49] Many studies have demonstrated true positive chest radiographs for asymptomatic patients with localized melanoma to range from 0-0.5%. [3][4][5]7,10,13 Low yields are also seen with presumptively more sensitive screening tests including brain, bone, liver, spleen, and gastrointestinal scans, ultrasound, and PET scans.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of staging chest radiographs and serum lactate dehydrogenase for localized melanoma

Wang

Johnson

Cascade

et al. 2004

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

Evaluation of staging chest radiographs and serum lactate dehydrogenase for localized melanoma

Wang

Johnson

Cascade

et al. 2004

Journal of the American Academy of Dermatology

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“…Available data are conflicting regarding whether SLNB after a wide excision is associated with a higher likelihood of false-negative results, but published data and expert opinion suggest that after extensive excision, flap reconstruction, or both the false-negative rate of SLNB is increased. 1,30,31 However, the existence of failures when the procedure is either performed by inexperienced surgeons or performed after excessively wide excision is not incompatible with the validity of the sentinel node hypothesis.…”

Section: Does the Available Evidence Support The Sentinel Node Hypothmentioning

confidence: 99%

“…1,2,14,[40][41][42][43][44][45][46][47][48] Accurate staging is widely accepted as the basis for counseling, therapeutic decision making, and prognostication in melanoma. Prognostic information is often invaluable and helps the vast majority of patients in an informed decision-making process.…”

Section: Does Slnb Accurately Predict Outcome?mentioning

confidence: 99%

“…[1][2][3][4][5] On opposing sides of the argument are real and theoretic benefits of SLNB that have been advocated juxtaposed against reasonable and justifiable concerns that have been raised by critics. Many questions remain unanswered and future trial results may or may not support reasons for performing SLNB today.…”

mentioning

confidence: 99%

“…The commonly cited sometimes heated current debate is interesting in itself, considering the fact that the majority of patients with melanoma are given a diagnosis of thin primary tumors or already have clinically evident metastases and, hence, do not fall within the current guidelines for consideration of SLNB. 1,6 New evidence often invalidates previously accepted therapy and replaces it with better and safer treatments. The optimal practice of medicine requires the fluid integration of clinical expertise with the best available levels of evidence and the patient's personal preferences and circumstances.…”

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confidence: 99%

See 2 more Smart Citations

The role of sentinel lymph node biopsy for melanoma: Evidence assessment

Johnson

Sondak

Bichakjian³

et al. 2006

Journal of the American Academy of Dermatology

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Merkel cell carcinoma: Critical review with guidelines for multidisciplinary management

Bichakjian

Lowe

Lao

et al. 2007

Cancer

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323

289

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Merkel cell carcinoma (MCC) is a relatively rare cutaneous malignancy that occurs predominantly in the older white population. The incidence of MCC appears to have tripled during the past 20 years; an increase that is likely to continue because of the growing number of older Americans. The pathogenesis of MCC remains largely unknown. However, ultraviolet radiation and immunosuppression are likely to play a significant pathogenetic role. Many questions currently remain unanswered regarding the biologic behavior and optimal treatment of MCC. Large, prospective, randomized studies are not available and are unlikely to be performed because of the rarity of the disease. The objective of this review was to provide a comprehensive reference for MCC based on a critical evaluation of the current data. The authors investigated the importance of sentinel lymph node biopsy as a staging tool for MCC to assess the status of the regional lymph node basin and to determine the need for additional therapy to the lymph node basin. In an attempt to standardize prospective data collection with the intention to define prognostic indicators, the authors also present histopathologic profiles for primary MCC and sentinel lymph nodes. The controversies regarding the appropriate surgical approach to primary MCC, the use of adjuvant radiation therapy, and the effective- A n increasing number of patients presenting with Merkel cell carcinoma (MCC) during the past 2 decades has focused attention on this cutaneous malignancy, which is seen primarily in older individuals. Based on the projection that, by 2030, 1 in 5 Americans will be aged !65 years, the increasing trend in MCC incidence is likely to continue.1 Currently, information regarding the biologic behavior and optimal treatment of MCC is limited given the paucity of high-level evidence and the absence of prospective, randomized trials. The objective of this review was to create a current reference for those involved in the care of patients with MCC or the investigation of this potentially aggressive malignancy. This review was based on a critical evaluation of the available data using an extensive PubMed search combined with our experience in the University of Michigan Comprehensive Cancer Center Multidisciplinary MCC program. EpidemiologyThe incidence of MCC is low compared with the incidence of other cutaneous malignancies. However, the trend is toward an increasing

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Staging Workup, Sentinel Node Biopsy, and Follow-up Tests for Melanoma

Cited by 41 publications

References 51 publications

Evaluation of staging chest radiographs and serum lactate dehydrogenase for localized melanoma

Evaluation of staging chest radiographs and serum lactate dehydrogenase for localized melanoma

The role of sentinel lymph node biopsy for melanoma: Evidence assessment

Merkel cell carcinoma: Critical review with guidelines for multidisciplinary management

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