Irrigation and fertilization are critical aspects in oil palm nurseries, so they need to be appropriately managed. Automatic drip irrigation technology has the advantage of saving water and labour usage. On the other hand, correctly applying slow-release fertilizer can fulfil the need for oil palm seedlings. The combination of drip irrigation and the application of slow-release NPK fertilizer can increase the effectiveness of maintaining oil palm seedlings. This study aims to obtain the best watering time and rate of slow-release NPK fertilizer on the growth and performance of oil palm seedlings in the main nursery. A field study was conducted since June 2021 until August 2021 at the Oil Palm Nursery Unit in Politeknik Negeri Lampung, Indonesia. The experiment arranges in split-plot design in randomized block design with three replications. The watering time is the main plot, and the slow-release NPK fertilizer rate is the subplot. The results showed that application of drip irrigation system with watering time in the morning, midday, and afternoon significantly affect stem diameter and number of leaves at three months after observation. The rate of 20 g plant-1 slow-release NPK fertilizer best-affected plant height, stem diameter, number of leaves, leaf area, and greenness index.