Standard-dose vs. low-dose CT protocols in the evaluation of localized lung lesions: Capability for lesion characterization—iLEAD study

Kubo, Takeshi; Ohno, Yoshiharu; Takenaka, Daisuke; Nishino, Mizuki; Gautam, Shiva; Sugimura, Kazuro; Kauczor, Hans Ulrich; Hatabu, Hiroto

doi:10.1016/j.ejro.2016.03.002

Cited by 33 publications

(15 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Low-dose CT detects and characterizes lung lesions in neutropenic patients early and with equal precision when compared to standard-dose CT [21,22]. Still, the use of standard-dose CT is more widespread than low-dose CT.…”

Section: Discussionmentioning

confidence: 99%

Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients

Stemler

Bruns

Mellinghoff

et al. 2020

JoF

View full text Add to dashboard Cite

Baseline chest computed tomography (BCT) in high-risk hematology patients allows for the early diagnosis of invasive pulmonary aspergillosis (IPA). The distribution of BCT implementation in hematology departments and impact on outcome is unknown. A web-based questionnaire was designed. International scientific bodies were invited. The estimated numbers of annually treated hematology patients, chest imaging timepoints and techniques, IPA rates, and follow-up imaging were assessed. In total, 142 physicians from 43 countries participated. The specialties included infectious diseases (n = 69; 49%), hematology (n = 68; 48%), and others (n = 41; 29%). BCT was performed in 57% (n = 54) of 92 hospitals. Upon the diagnosis of malignancy or admission, 48% and 24% performed BCT, respectively, and X-ray was performed in 48% and 69%, respectively. BCT was more often used in hematopoietic cell transplantation and in relapsed acute leukemia. European centers performed BCT in 59% and non-European centers in 53%. Median estimated IPA rate was 8% and did not differ between BCT (9%; IQR 5–15%) and non-BCT centers (7%; IQR 5–10%) (p = 0.69). Follow-up computed tomography (CT) for IPA was performed in 98% (n = 90) of centers. In high-risk hematology patients, baseline CT is becoming a standard-of-care. Chest X-ray, while inferior, is still widely used. Randomized, controlled trials are needed to investigate the impact of BCT on patient outcome.

show abstract

Section: Discussionmentioning

confidence: 99%

Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients

Stemler

Bruns

Mellinghoff

et al. 2020

JoF

View full text Add to dashboard Cite

show abstract

“…A 10 point likert scale was used for all scoring to characterize the 133 target nodule images according to the criteria of malignancy described in [39, 40]. Each of the 133 nodule images has 7 scores:…”

Section: Tissue-specific Mrf Clinical Performance In Nodule Diagnosismentioning

confidence: 99%

A Feasibility Study of Extracting Tissue Textures From a Previous Full-Dose CT Database as Prior Knowledge for Bayesian Reconstruction of Current Low-Dose CT Images

Gao

Zhang

Moore

et al. 2019

IEEE Trans. Med. Imaging

View full text Add to dashboard Cite

Markov random field (MRF) has been widely used to incorporate a priori knowledge as penalty or regularizer to preserve edge sharpness while smoothing the region enclosed by the edge for pieces-wise smooth image reconstruction. In our earlier study, we proposed a type of MRF reconstruction method for low-dose CT (LdCT) scans using tissue-specific textures extracted from the same patient’s previous full-dose CT (FdCT) scans as prior knowledge. It showed advantages in clinical applications. This study aims to remove the constraint of using previous data of the same patient. We investigated the feasibility of extracting the tissue-specific MRF textures from an FdCT database to reconstruct a LdCT image of another patient. This feasibility study was carried out by experiments designed as follows. We constructed a tissue-specific MRF-texture database from 3990 FdCT scan slices of 133 patients who were scheduled for lung nodule biopsy. Each patient had one FdCT scan (120kVp/100mAs) and one LdCT scan (120kVp/20mAs) prior to biopsy procedure. When reconstructing the LdCT image of one patient among the 133 patients, we ranked the closeness of the MRF-textures from the other 132 patients saved in the database and used them as the a prior knowledge. Then, we evaluated the reconstructed image quality using Haralick texture measures. For any patient within our database, we found more than eighteen patients’ FdCT MRF texures can be used without noticeably changing the Haralick texture measures on the lung nodules (to be biopsied). These experimental outcomes indicate it is promising that a sizable FdCT texture database could be used to enhance Bayesian reconstructions of any incoming LdCT scans.

show abstract

“…Different patterns of pulmonary lesions are considered to increase the likelihood of IPA in high‐risk patients. The halo, a nodule with surrounding ground‐glass opacity, is the most specific sign of IPA, but well‐shaped nodules without halo, air‐crescent signs, and new cavities are also indicative of IPA or other mould infections, and most of these lesions are easily detectable even by current low‐dose, for example 50mAs, CT techniques . Because the lesion size can be sometimes small, the use of thin slices of max.…”

Section: Diagnostic Toolsmentioning

confidence: 99%

Diagnostic work up to assess early response indicators in invasive pulmonary aspergillosis in adult patients with haematologic malignancies

Heinz

Vehreschild

Buchheidt

2019

Mycoses

View full text Add to dashboard Cite

In immunocompromised patients with acute leukaemia as well as in allogeneic hematopoietic stem cell transplant patients, pulmonary lesions are commonly seen. Existing guidelines provide useful algorithms for diagnostic procedures and treatment options, but they do not give recommendations on how to evaluate early success or failure and if or when it is best to change therapy. Here, we review the diagnostic techniques currently used in association with clinical findings and propose an approach using a combination of computer tomography, clinical and all available biomarkers and inflammation parameters, especially those positive at baseline, to assess early response in invasive pulmonary aspergillosis. Computed tomography scans should be carried out at regular intervals during early and long-term follow-up. Imaging on day seven, or even earlier in clinically unstable patients, combined with an additional testing of biomarkers and inflammatory markers in between, is needed for a reliable assessment at day 14. If no improvement is seen after 2 weeks of therapy or the clinical condition is deteriorating, a change of antifungal therapy should be considered. Alleged breakthrough infections or treatment failure should undergo early diagnostic workup, including tissue biopsies when possible, to retrieve fungal cultures for resistance testing. K E Y W O R D S Aspergillus, biomarkers, diagnosis, imaging, treatment monitoring | 487 HEINZ Et al.

show abstract

Standard-dose vs. low-dose CT protocols in the evaluation of localized lung lesions: Capability for lesion characterization—iLEAD study

Cited by 33 publications

References 21 publications

Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients

Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients

A Feasibility Study of Extracting Tissue Textures From a Previous Full-Dose CT Database as Prior Knowledge for Bayesian Reconstruction of Current Low-Dose CT Images

Diagnostic work up to assess early response indicators in invasive pulmonary aspergillosis in adult patients with haematologic malignancies

Contact Info

Product

Resources

About