Standardization and Evaluation of Herbal Antihypertensive Sarpagandha (Reserpine) Tablet Formulations

Abstract

The need for herbal medicines is rising day by day tremendously all over the world. Many pharma industries are nowadays directing their studies on herbal material for their probable therapeutic values. In various scientifi c journals, a growing volume of research publications relied upon plant-based drugs and formulations. Hypertension is an important chronic disorder in economically developed as well as developing countries. According to WHO guidelines, it is necessary to standardize the herbal products that reach patients. Hence, standardizing the herbal antihypertensive formulations is necessary to give safe and eff ective medicines to the patients and society. The herbal antihypertensive formulation was standardized according to Ayurvedic Pharmacopeia and WHO guidelines. Various parameters such as botanical, physicochemical, pharmacological and toxicological were studied. A pharmacological study was carried to screen the selected marketed formulations for hemolytic and antihypertensive activity. The study showed that all formulations pass most of the standardization parameters and can be recommended for human beings. The outcome of present study will support the process of regulatory agencies and help in maintaining the quality of herbal medicines.