Standardization of Dynamic Contrast-Enhanced Ultrasound for the Evaluation of Antiangiogenic Therapies

Lassau, Nathalie; Chapotot, Louis; Benatsou, Baya; Vilgrain, Valérie; Kind, Michèle; Lacroix, Joëlle; Cuinet, M.; Taïeb, S.; Aziza, R.; Sarran, A.; Labbé, Catherine; Gallix, B.; Lucidarme, O.; Ptak, Y; Rocher, Laurence; Caquot, Louis Michel; Chagnon, S; Marion, D.; Luciani, Alain; Uzan-Augui, J.; Koscielny, Serge

doi:10.1097/rli.0b013e31826dc255

Cited by 68 publications

(54 citation statements)

References 21 publications

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“…The aim of this study was -To evaluate retrospectively the characteristics of normal skin by ultrasound examinations performed with a high-frequency transducer [5][6][7][8][9][10][11][12][13][14][15][16][17].…”

Section: Aimsmentioning

confidence: 99%

High-resolution color-Doppler ultrasound for the study of skin growths

Santolo

Sagnelli

Mancini³

et al. 2015

Arch Dermatol Res

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the difference between variables was analyzed with statistical Chi square test or Fisher's when appropriate. The strength of the relationship between variables was analyzed with Pearson's r coefficient. The sensitivity and specificity of US tests were also calculated. Sixty-five malignant lesions and 39 benign lesions were identified at Doppler US. In the 34 melanomas, typical US and vascular patterns were identified depending on the thickness of the lesion and a strong correlation between the latter and Breslow index was confirmed. Doppler US is a valuable diagnostic tool for the study of skin and for pre-excision characterization of skin lesions.

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Section: Aimsmentioning

confidence: 99%

High-resolution color-Doppler ultrasound for the study of skin growths

Santolo

Sagnelli

Mancini³

et al. 2015

Arch Dermatol Res

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“…DCE-US explores microvascularization better than Doppler and enables the evaluation of tumor vascularization changes through the quantification of perfusion parameters (Marcus et al 2009). Among those criteria, the area under the blood-volume curve could be an earlier reliable predictor of therapeutic response (Lassau et al 2011(Lassau et al , 2012a. In a recent French multicenter series of 539 patients with various malignancies treated with antiangiogenic therapies, including NETs, early (day 30) variations of perfusion parameters of liver metastases were correlated with tumor responses at 6 months, according to RECIST criteria and overall survival (OS; Lassau et al 2012a,b).…”

Section: Dce-based Imaging and Perfusion Parametersmentioning

confidence: 99%

Evaluating digestive neuroendocrine tumor progression and therapeutic responses in the era of targeted therapies: state of the art

Mestier¹,

Dromain²,

d’Assignies³

et al. 2013

Endocrine-Related Cancer

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Well-differentiated neuroendocrine tumors (NETs) are a group of heterogeneous rare tumors. They are often slow-growing and patients can have very long survival, even at the metastatic stage. The evaluation of tumor progression and therapeutic responses is currently based on Response Evaluation Criteria In Solid Tumors v1.1 (RECIST) criteria. As for other malignancies, RECIST criteria are being reexamined for NETs in the era of targeted therapies because tumor response to targeted therapies is rarely associated with shrinkage, as opposed to prolonged progression-free survival. Therefore, size-based criteria no longer seem to be suitable to the assessment of NET progression and therapeutic responses, especially considering targeted therapies. New imaging criteria, combining morphological and functional techniques, have proven relevant for other malignancies treated with targeted therapies. To date, such studies have rarely been conducted on NETs. Moreover, optimizing the management of NET patients also requires considering clinical, biological, and pathological aspects of tumor evolution. Our objectives herein were to comprehensively review current knowledge on the assessment of tumor progression and early prediction of therapeutic responses and to broaden the outlook on well-differentiated NETs, in the era of targeted therapies.

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“…applications are essentially the monitoring of tumour response to drugs [8,14,15]. Some authors used this method for the assessment of muscle perfusion.…”

Section: Correlationsmentioning

confidence: 99%

“…Nevertheless, comparison of values in a single patient in our study should have reduced this potential bias. The same method as in other recent studies was used [11] (use of Sonovue, bolus of 4.8 cc, analysis on raw data by software), which is in fact the reference method for the use of time intensity curves in parenchyma [8,23].…”

Section: Limitationsmentioning

confidence: 99%

“…According to the TASC II consensus document [1], this is related to a systolic ankle blood pressure of less than 30-50 mm Hg for patients with ischaemic rest pain, 50-70 mm Hg for patients with ischaemic ulcers, a toe pressure (TBP) of < 50 mm Hg in diabetic patients, and to transcutaneous pressure in oxygen (TcPO2) of less than 30 mm Hg. In spite of some possible artefacts, TcPO2 adequately measures the oxygenation of the skin, used with contrast (specifi c US techniques), allow visualization of macro and microvasculature in diff erent parenchyma such as the liver or the spleen [6].With the use of computerized mathematical models, time intensity curves are able to describe the dynamics of the microbubbles in the tissue microcirculation [7,8]. Contrast enhanced ultrasonography has been used for the quantifi cation of vascularization in neoplastic tumours [7] and is easy to perform in the setting of a vascular lab with ultrasound explorations, as demonstrated by several studies showing a potential for its use in peripheral arterial disease (PAD): Weber et al found a correlation between local blood volume in healthy volunteers, calculated by replenishments kinetics of CEUS (SH U 508A, Levovist © ) and muscular fi bre adjacent capillarization [9].…”

Section: Introductionmentioning

confidence: 99%

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Is contrast enhanced ultrasonography a useful tool for the evaluation of muscular microcirculation in patients with critical limb ischaemia?

Seinturier

Blaise

Pichot

et al. 2017

Vasa

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Summary:Background: Evaluation of skin microcirculation in patients with critical limb ischemia (CLI) may be achieved by the measurement of transcutaneous oxygen pressure or skin perfusion pressure, but there is no practical method available for the evaluation of muscle microcirculation. Contrast enhanced ultrasonography (CEUS) has been used to assess muscle perfusion in patients with peripheral arterial disease. We conducted a monocentric pilot study evaluating the ability of CEUS to assess the impact of arterial revascularization on the perfusion of the calf muscle in patients with CLI. Patients and methods: Patients with CLI (TASC II criteria) and a possibility of proximal or medial revascularization were included. In addition to TcPO2 and toe systolic blood pressure measurements, CEUS of the calf muscle was performed just before and one month after the therapeutic procedure. Parameters derived from muscular perfusion curves were evaluated in a blinded fashion and compared with the clinical outcome. Results: Thirty eight patients were included (74 % men, median age 71 years, 53 % diabetics). Thirty benefi ted from revascularization with a clinical success rate of 70 %. Twenty three patients could benefi t from analysis before and after revascularization. No signifi cant difference was shown in time to peak (22.3 s vs 24.0 s, P = 0.61) nor in peak intensity (2.30 dB vs 1.27 db, P = 0,26), contrasting with signifi cant improvements of TcPO2 (43 mm Hg vs 20 mm Hg, P = 0.007) and toe systolic blood pressure (54 mm Hg vs 32 mm Hg, P = 0.002). Conclusions: The evaluation of muscular microvascular perfusion by CEUS as performed in this study is not enough sensitive to change to allow a clinically relevant evaluation of the improvement in muscle microvascular perfusion in patients with CLI benefi ting from revascularization procedures.

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Standardization of Dynamic Contrast-Enhanced Ultrasound for the Evaluation of Antiangiogenic Therapies

Abstract: The DCE-US methodology has been successfully provided to several centers across France together with strict rules for quality assessment. Only 3% of examinations carried out at these centers were considered not interpretable.

Cited by 68 publications

References 21 publications

High-resolution color-Doppler ultrasound for the study of skin growths

High-resolution color-Doppler ultrasound for the study of skin growths

Evaluating digestive neuroendocrine tumor progression and therapeutic responses in the era of targeted therapies: state of the art

Is contrast enhanced ultrasonography a useful tool for the evaluation of muscular microcirculation in patients with critical limb ischaemia?

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