Standardization of potentiometric cells in propan-2-ol-water

Ràfols, Clara; Rosés, Martı́; Bosch, Elisabeth

doi:10.1016/0003-2670(93)80244-f

Cited by 6 publications

(1 citation statement)

References 22 publications

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“…The most frequently studied systems in this respect are (water + alcohol) mixtures [8]. Some authors [9,10] describe the relationships between pK a of acids and relative dielectric constants (ε −1 ), as being almost linear, while others [11,12] consider these relationships as being non-linear.…”

Section: Introductionmentioning

confidence: 99%

Molecular Heteroconjugation Equilibria in (n-Butylamine + Acetic Acid) Systems in Binary (Dimethyl Sulfoxide + 1,4-Dioxane) Solvent Mixtures

et al. 2007

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The acidity constants of molecular acid, K a (HA), cationic acid, K a (BH + ), as well as the equilibrium constants of anionic homoconjugation, K AHA − , cationic homoconjugation, K BHB + , and molecular heteroconjugation, K AHB , have been determined in (n-butylamine + acetic acid) systems without proton transfer in binary [dimethyl sulfoxide (DMSO) + 1,4-dioxane (D)] solvent mixtures. The constants were determined by using the potentiometric titration method at a fixed ionic strength. It is concluded that the molecular heteroconjugation constants in the mixed solvent systems studied are linearly related to the 1,4-dioxane content. Furthermore, in the (acid + base) systems without proton transfer, the direction of titration (direct B + HA or reverse HA + B) has been found to affect the precision of determination of reliable values of molecular heteroconjugation constants. Moreover, it has been found that the relative dielectric constants of the solvent mixtures studied change linearly as a function of solvent composition, as well as solvent components do not show interactions of solvent-solvent type.

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Section: Introductionmentioning

confidence: 99%

Molecular Heteroconjugation Equilibria in (n-Butylamine + Acetic Acid) Systems in Binary (Dimethyl Sulfoxide + 1,4-Dioxane) Solvent Mixtures

et al. 2007

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Physicochemical Properties of a New Multicomponent Cosolvent System for the pK_a Determination of Poorly Soluble Pharmaceutical Compounds

Box

Völgyi

Ruiz

et al. 2007

Helvetica Chimica Acta

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A mixture of cosolvents is described that significantly improves the solubility of most pharmaceutical compounds. The mixture consists of equal volumes of MeOH, 1,4‐dioxane, and MeCN, thereby containing polar and nonpolar solvents, and is referred to as MDM (from MeOH, dioxane, and MeCN). MDM is mixed with H2O until the required composition is reached. The utility of this system is that it enables analytical measurements to be performed on a wide range of compounds where measurements would be impaired in aqueous solution. We present the physicochemical characteristics of MDM/H2O mixtures (density, dielectric constant, psKw) and the principles of pKa measurement in this solvent/H2O mixture. We also present pKa values in H2O of several drug compounds determined from values measured in MDM/H2O mixtures.

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Variation of acidity constants and pH values of some organic acids in water—2-propanol mixtures with solvent composition. Effect of preferential solvation

Bosch

Ràfols

Rosés

1995

Analytica Chimica Acta

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Standardization of potentiometric cells in propan-2-ol-water

Cited by 6 publications

References 22 publications

Molecular Heteroconjugation Equilibria in (n-Butylamine + Acetic Acid) Systems in Binary (Dimethyl Sulfoxide + 1,4-Dioxane) Solvent Mixtures

Molecular Heteroconjugation Equilibria in (n-Butylamine + Acetic Acid) Systems in Binary (Dimethyl Sulfoxide + 1,4-Dioxane) Solvent Mixtures

Physicochemical Properties of a New Multicomponent Cosolvent System for the pK_a Determination of Poorly Soluble Pharmaceutical Compounds

Variation of acidity constants and pH values of some organic acids in water—2-propanol mixtures with solvent composition. Effect of preferential solvation

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Standardization of potentiometric cells in propan-2-ol-water

Cited by 6 publications

References 22 publications

Molecular Heteroconjugation Equilibria in (n-Butylamine + Acetic Acid) Systems in Binary (Dimethyl Sulfoxide + 1,4-Dioxane) Solvent Mixtures

Molecular Heteroconjugation Equilibria in (n-Butylamine + Acetic Acid) Systems in Binary (Dimethyl Sulfoxide + 1,4-Dioxane) Solvent Mixtures

Physicochemical Properties of a New Multicomponent Cosolvent System for the pKa Determination of Poorly Soluble Pharmaceutical Compounds

Variation of acidity constants and pH values of some organic acids in water—2-propanol mixtures with solvent composition. Effect of preferential solvation

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Physicochemical Properties of a New Multicomponent Cosolvent System for the pK_a Determination of Poorly Soluble Pharmaceutical Compounds