Standardized bioactive fraction of Phaleria macrocarpa (Proliverenol) prevents ethanol-induced hepatotoxicity via down-regulation of NF-κB-TNFα-caspase-8 pathway

Berlian, Guntur; Tandrasasmita, Olivia Mayasari; Tjandrawinata, Raymond R.

doi:10.1016/j.apjtb.2016.06.007

Cited by 10 publications

(14 citation statements)

References 27 publications

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Section: Introductionmentioning

confidence: 54%

“…The hepatoprotective activity of this PM extract was reported by Berlian et al [10] using in vitro ethanol-induced LF model. PM extracts suppressed the expressions of NF-κB, TNF-α, and caspase-8 [10]. Hendra et al [6] also reported that PM fruit extract has antioxidant and anti-inflammation using an in vitro model.…”

Section: Introductionmentioning

confidence: 54%

“…The dried powder PM extract (Proliverenol) was prepared by Dexa Laboratories of Biomolecular Sciences (Batch No. RP130116), as described by Kim et al [8] and Berlian et al [10]. Proliverenol was a bioactive fraction extracted from P. macrocarpa fruit using subcritical water extraction, as described by Kim et al [8]; Berlian et al [10]; and Sundari et al [9].…”

Section: Pm Aqueous Extract (Proliverenol) and Silymarinmentioning

confidence: 99%

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Antifibrotic Activity of Phaleria macrocarpa Extract in Rat Liver-fibrosis Model: Focus on Oxidative Stress Markers, TGF-β1 and MMP-13

Wardhani

Sundari

Tjandrawinata³

et al. 2020

Open Access Maced J Med Sci

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AIM: This study was aimed to determine the antifibrotic activity of Phaleria macrocarpa (PM) extract in liver fibrosis (LF) and its possible mechanism in the rat model. METHODS: Sprague Dawley male rats were injected with 2 mL/kg BW of carbon tetrachloride intraperitoneally twice a week for 2 weeks, followed by 1 mL/kg BW for 6 weeks. Afterward, the treatments began from the 3rd week: Silymarin 100 mg/kg BW/day, standardized PM extract (Proliverenol) 75 or 150 mg/kg BW/day orally. Rats were sacrificed in the 8th week. Blood and liver were collected to analyze liver function, liver damage and fibrosis marker, oxidative stress markers, pro-fibrogenic cytokine, and antifibrotic marker. RESULTS: Our study showed that the treatment of silymarin and PM resulted in the normalized activity of liver function, followed by the amelioration of oxidative stress, demonstrated by the decreased malondialdehyde levels and an increased ratio of glutathione and glutathione disulfide. All markers examined showed that PM extract has antioxidant activity due to decreased hepatic stellate cell activation. We also found a decrease in tumor growth factors-β1 and protein expressions of matrix metalloproteinases-13 in all treatment groups compared to the carbon tetrachloride group. There were tendencies of the decreased fibrotic area following improvements of biochemical parameters. CONCLUSION: PM extracts ameliorate carbon tetrachloride-induced LF. The proposed mechanism is by overcoming oxidative stress and regulating pro-fibrogenic cytokine and antifibrotic markers.

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Section: Introductionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 54%

Section: Pm Aqueous Extract (Proliverenol) and Silymarinmentioning

confidence: 99%

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Antifibrotic Activity of Phaleria macrocarpa Extract in Rat Liver-fibrosis Model: Focus on Oxidative Stress Markers, TGF-β1 and MMP-13

Wardhani

Sundari

Tjandrawinata³

et al. 2020

Open Access Maced J Med Sci

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“…The mechanism of action and molecular activities of various herbs have been investigated in vivo and in vitro in our previous studies. [5][6][7][8][9][10][11][12] In recent years, many studies have been carried out on isolation, determination of the phytochemical profile, and characterization of the pigments of Cinnamomum burmannii. 13,14 It has been recommended for medicinal use because it displays antibacterial 15 and antioxidant activities.…”

Section: Introductionmentioning

confidence: 99%

<p>Gastroprotective Effect of DLBS2411 Bioactive Fraction from <em>Cinnamomum burmannii</em> Against Ethanol-Induced Gastric Damage in Rats</p>

Tjandrawinata¹,

Nailufar²

2020

JEP

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Background: The study was carried out to evaluate the anti-ulcerative and gastroprotective effect of DLBS2411, a bioactive fraction from Cinnamomum burmannii (Nees & T. Nees) Blume, in Wistar rats (Rattus norvegicus). Methods: The rats were divided into five treatment groups, which were the Normal control group, Negative control group (ethanol-induced) and two treatment groups: DLBS2411 at the doses of 25 mg/kg body weight (BW) and 50 mg/kg BW, and the Positive control group treated with sucralfate at the dose of 100 mg/kg BW. Gastroprotective effect was measured by the ulcerative lesion index, ulcer surface area, percentage of lesion area, and cure ratio. Hematological and histopathological analyses were also conducted to gain additional data regarding the gastroprotective effect of DLBS2411 in the rats' stomachs. Results: DLBS2411 was found to contain not less than 15% of total phenolic compounds. Treatment with DLBS2411 at doses of 25 mg/kg BW and 50 mg/kg BW significantly reduced the percentage of ulcer area in rats. The percentage of ulcer area for the Negative control group and both doses in the DLBS2411 treatment group reached 22.64±6.82%, 6.75 ±4.41%, and 6.18±4.63%, respectively. Ulcer surface area in the treatment groups and Positive control group also decreased. Histopathological data showed that gastric epithelial cells in the Negative control group were more severely ulcerated than in the treatment group of DLBS2411 and the Positive control group. Conclusion: This study showed that DLBS2411 at the dose of 50 mg/kg BW was more effective in protecting the stomach lining than DLBS2411 at the dose of 25 mg/kg BW, as measured by percentage of ulceration inhibition and the ulcerative lesion index.

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“…[8][9][10][11] Natural-based remedies have also been recently recommended to substitute the uses of fluoride and other chemical compounds addressed for oral health. Exhibiting good antimicrobial activity, Nigella sativa L. seed, known as black cumin, has been widely used as food preservatives.…”

Section: Ijpsr (2017) Volume 8 Issue 7 (Research Article)mentioning

confidence: 99%

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2017

IJPSR

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Our previous study highlighted the antimicrobial activity evaluation of Nigella sativa seed oil extract that was obtained from supercritical fluid extraction using carbon dioxide (SCFE-CO 2 ) on Gram positive pathogenic bacteria. The aim of this study was to formulate oil-in-water (o/w) emulsion of previous N. sativa seed oil extract and to investigate its antimicrobial activity against Streptococcus mutans and Streptococcus sanguis as the most common causative bacteria of dental caries. Oil-in-water emulsion containing 10% N. sativa seed oil extract (DLBS1355) exhibited good inhibition activity on both S. mutans and S. sanguis. Time-kill assay and biofilm inhibition assay were conducted using emulsion with 0.5% N. sativa seed oil extract content. The results showed bactericidal and biofilm inhibition activities on both tested bacteria. Antimicrobial activity of the emulsion was found higher on S. sanguis than S. mutans. Results of the present study showed that emulsification process did not significantly affect the antimicrobial activity of N. sativa seed oil extract and the formulated N. sativa oil-in-water emulsion could further be used as an antimicrobial agent against dental cariogenic bacteria.

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Standardized bioactive fraction of Phaleria macrocarpa (Proliverenol) prevents ethanol-induced hepatotoxicity via down-regulation of NF-κB-TNFα-caspase-8 pathway

Cited by 10 publications

References 27 publications

Antifibrotic Activity of Phaleria macrocarpa Extract in Rat Liver-fibrosis Model: Focus on Oxidative Stress Markers, TGF-β1 and MMP-13

Antifibrotic Activity of Phaleria macrocarpa Extract in Rat Liver-fibrosis Model: Focus on Oxidative Stress Markers, TGF-β1 and MMP-13

<p>Gastroprotective Effect of DLBS2411 Bioactive Fraction from <em>Cinnamomum burmannii</em> Against Ethanol-Induced Gastric Damage in Rats</p>

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