Standardized flavonoid-rich fraction of Artemisia princeps Pampanini cv. Sajabal induces apoptosis via mitochondrial pathway in human cervical cancer HeLa cells

Pea lectin inhibits growth of Ehrlich ascites carcinoma cells by inducing apoptosis and G2/M cell cycle arrest in vivo in mice

“…Changes in the mRNA expression profiling of these genes occurs due to cancer cell response to chemotherapeutic drugs. A decrease in the expression of Bcl-X L and increased in the expression of Bax and Bak was observed after treating of HeLa cells with FRAP (Ju et al 2012). Such type of results were also reported for Musca domestica Larva lectin (MLL) which induces Bcl-2 decreased during the Bax increased (Zhao et al 2010).…”

Chemopreventive effects of standardized ethanol extract from the aerial parts of Artemisia princeps Pampanini cv. Sajabal via NF-κB inactivation on colitis-associated colon tumorigenesis in mice

“…On the other hand, IL-1β is a pleiotropic pro-inflammatory cytokine with profound effects on several diseases including cancers. In the present extract of A. princeps was reported to induce apoptosis in various human cancer cells by the activation of caspase-8, caspase-9, caspase-3 and reducing the expressions of Bcl-2 family proteins (Ju et al, 2012;Kim et al, 2013). Taken together, the results obtained in the present study from the AOM/DSS colon cancer model and the cell-based study suggest that EAPP attenuated the production of pro-inflammatory cytokines through the NF-κB inactivation and reduced the pathological infiltration of immune cells.…”

“…We previously found that standardized flavonoid-rich fraction of A. princeps Pampanini cv. Sajabal induces apoptosis via mitochondrial pathway in human cervical cancer HeLa cells (Ju et al, 2012) and Artemisia leaf extract also induces apoptosis in human endometriotic cells through regulation of the p38 and NF-κB pathways . Its flavonoid components, such as, eupatilin, jaceosidin, and eupafolin, induce G2/M cell cycle arrest and apoptosis via the caspase-and mitochondrial-dependent pathway and the inactivation of NF-κB pathways in human endometrial and cervical cancer cells (Cho et al, 2011;Chung et al, 2010;Lee et al, 2013).…”

Long-term Treatment with Oriental Medicinal Herb Artemisia princepsAlters Neuroplasticityin a Rat Model of Ovarian Hormone Deficiency

“…As Artemisia princeps and its components have demonstrated a number of bioactivities, including insulin regulation [37,38, 39], antioxidant [40], proinflammatory [41] or anti-inflammatory [42, 43], and cytotoxic [44, 45] effects, it was hypothesized that it may also influence hippocampal LTD in a model of ovarian hormone deficiency.…”