StandardizedPassiflora incarnataL. Extract Reverts the Analgesia Induced by Alcohol Withdrawal in Rats

Abstract

Passiflora incarnata L. (Passifloraceae) has been traditionally used for treatment of anxiety, insomnia, drug addiction, mild infections, and pain. The aim of this study was to investigate the effect of a commercial extract of P. incarnata in the analgesia induced by alcohol withdrawal syndrome in rats. In addition, brain-derived neurotrophic factor and interleukin-10 levels were evaluated in prefrontal cortex, brainstem, and hippocampus. Male adult rats received by oral gavage: (1: water group) water for 19 days, 1 day interval and water (8 days); (2: P. incarnata group) water for 19 days, 1 day interval and P. incarnata 200 mg/kg (8 days); (3: alcohol withdrawal group) alcohol for 19 days, 1 day interval and water (8 days); and (4: P. incarnata in alcohol withdrawal) alcohol for 19 days, 1 day interval and P. incarnata 200 mg/kg (8 days). The tail-flick and hot plate tests were used as nociceptive response measures. Confirming previous study of our group, it was showed that alcohol-treated groups presented an increase in the nociceptive thresholds after alcohol withdrawal, which was reverted by P. incarnata, measured by the hot plate test. Besides, alcohol treatment increased brain-derived neurotrophic factor and interleukin-10 levels in prefrontal cortex, which was not reverted by P. incarnata. Considering these results, the P. incarnata treatment might be a potential therapy in the alcohol withdrawal syndrome. Copyright © 2017 John Wiley & Sons, Ltd.

Effects of Foliar Treatment with a Trichoderma Plant Biostimulant Consortium on Passiflora caerulea L. Yield and Quality

“…The edible parts are considered to be nutraceutical/functional food [39]. The aerial parts of Passiflora plants are used as infusions, extracts, or tinctures due to their various effects: anti-depressive/anti-anxiolytic [40,41]; sedative/anti-sleep disorders [42]; anti-spasmolytic [43]; anti-asthma/anti-respiratory disorders [44]; anti-diabetic/hypolipidemic [45]; anti-hypertensive [46]; and, anti-addictive [47,48]. These effects have been related to the bioactive polyphenols and flavonoids [49,50] and their antioxidant [51][52][53], antimicrobial [52], prebiotic [51], and anti-inflammatory and analgesic [54][55][56] activities.…”

Phytotherapeutic agents on anxiety control in dentistry: a literature review

“…It has sedative and anxiolytic properties (Dhawan, Kumar & Sharma, 2001;Carlini, 2003;Miroddi et al, 2013;da Cunha et al, 2021). It has been used to treat anxiety, insomnia, drug dependence, mild infections, and pain (Schunck et al, 2017). Additionaly, it can be used to control anxiety caused by dental procedures (Kaviani et al, 2013;da Cunha et al, 2021).…”

Comparison of the Effects of Passiflora Incarnata and Piroxicam in opioids withdrawal-Induced Myalgia and Anxiety: A randomized Clinical Trial

“…Passiflora incarnata L. (Passifloraceae) is used in traditional herbal medicines, which has shown different therapeutic properties 16,17 . Interestingly, in India, it is used to treat morphine's dependence 18, while in Africa, it is used for its sedative and analgesic properties 19,20 . The P. incarnata is not narcotic or addictive, so it is used in tea, pills, and drops for treatment of sleep disorders, restlessness, irritability, and anxiety 15,21,22 .…”

“…In recent years, many studies have been conducted on the effective substances of this plant as anti-anxiety and toxicity properties [23][24][25] , and as a benzodiazepinereceptor agonist 24 . Animal studies have also revealed that P. incarnata L. has been effective in controlling the pain caused by alcohol withdrawal 20 . Meanwhile, other studies have indicated that when the plant is used in the treatment, it reduces the need for opioids in addicts 26 .…”

“…A , GABA B and its effect on opioid receptor 20,36 . A considerable part of the scientific literature has provided pre-clinical evidence of the beneficial properties of P. incarnata in the treatment of addictive behaviors related to substances such as amphetamine, nicotine, cannabis, ethanol, and benzodiazepine 34,37,38 .…”