2019
DOI: 10.1016/j.cca.2019.07.022
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Standardized measurement of circulating vitamin D [25(OH)D] and its putative role as a serum biomarker in Alzheimer's disease and Parkinson's disease

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Cited by 47 publications
(37 citation statements)
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“…One limitation of our study was that the measurement of 25(OH)D was not aligned with the standard procedures and materials according to the National Institute for Standard and Technology (NIST) target value as recommended by the Vitamin D Standardization Program (VDSP) . It is noteworthy that there is not univocal consensus on the reference values of vitamin D status .…”
Section: Discussionmentioning
confidence: 95%
“…One limitation of our study was that the measurement of 25(OH)D was not aligned with the standard procedures and materials according to the National Institute for Standard and Technology (NIST) target value as recommended by the Vitamin D Standardization Program (VDSP) . It is noteworthy that there is not univocal consensus on the reference values of vitamin D status .…”
Section: Discussionmentioning
confidence: 95%
“…Also, we did not notice any crucial differences between studied genotypes in the clinical manifestations of MS that could be explained by the limited samples described herein. Moreover, the cerebral activity and connectivity of neural circuits responsible for locomotor functions, that are included in the EDSS scoring, depend also on the other factors that we have not investigated in our study, such as serum concentrations of vitamin D [ 41 ], which is involved in the immune responses and brain functions [ 42 ] and is considered a serum biomarker in neurological diseases as well [ 43 ]. The risk, progression, and clinical manifestation of MS has been shown to be associated also with the other SNVs [ 44 ] that we have not analysed in our study and might have an impact on our results.…”
Section: Discussionmentioning
confidence: 99%
“…Hypovitaminosis D appears to play an important role in a number of extraskeletal diseases such as several autoimmune diseases [8,9] or Alzheimer's and Parkinson's disease [10]. Vitamin D plays a key role in various physiological processes such as the regulation of brain development and activities in adulthood [11].…”
Section: Introductionmentioning
confidence: 99%